1.
Steroids
; 68(1): 85-96, 2003 Jan.
Article
in English
| MEDLINE
| ID: mdl-12575693
ABSTRACT
A facile six-step synthesis of 2,2,3,4,4-d5-androsterone-beta-D-glucuronide (1) starting from epiandrosterone (2) in 63% yield is described and compared with several alternative synthetic pathways. Compound 1 can be used as an internal standard in screening procedures for anabolic steroids to monitor the hydrolysis step of the steroid glucuronides prior to gas chromatography-mass spectrometry (GC-MS) analysis. Thus, a time consuming solid-phase extraction step to remove possible hydrolysis inhibitors can be omitted.
Subject(s)
Anabolic Agents/urine , Androsterone/analogs & derivatives , Androsterone/chemical synthesis , Illicit Drugs/urine , Anabolic Agents/standards , Androsterone/standards , Deuterium , Gas Chromatography-Mass Spectrometry , Humans , Hydrolysis , Mass Screening/methods , Reference Standards
2.
Int J Radiat Biol Relat Stud Phys Chem Med
; 13(3): 289-91, 1967.
Article
in English
| MEDLINE
| ID: mdl-5300689