Subject(s)
Anetoderma/etiology , Cellulite/surgery , Dermatologic Surgical Procedures/adverse effects , Postoperative Complications/etiology , Adult , Anetoderma/diagnosis , Buttocks/surgery , Dermatologic Surgical Procedures/instrumentation , Dermatologic Surgical Procedures/methods , Female , Humans , Postoperative Complications/diagnosisSubject(s)
Anetoderma/chemically induced , Injection Site Reaction/etiology , Neurofibromatosis 1/diagnosis , Vitamin K 1/adverse effects , Anetoderma/complications , Anetoderma/diagnosis , Anetoderma/pathology , Biopsy , Diagnosis, Differential , Female , Humans , Infant , Injection Site Reaction/diagnosis , Injection Site Reaction/pathology , Injections, Intramuscular/adverse effects , Neurofibromatosis 1/complications , Neurofibromatosis 1/genetics , Neurofibromatosis 1/pathology , Neurofibromin 1/genetics , Skin/pathology , Vitamin K 1/administration & dosageSubject(s)
Anetoderma/diagnosis , Leprosy, Lepromatous/diagnosis , Adolescent , Diagnosis, Differential , Humans , MaleABSTRACT
No disponible
Subject(s)
Humans , Male , Child, Preschool , Anetoderma/complications , Anetoderma/diagnosis , Mollusca , Food Hypersensitivity/diagnosis , Food Hypersensitivity/diagnostic imagingABSTRACT
Anetoderma is a rare cutaneous disorder characterized by focal loss of dermal elastic tissue, resulting in macular atrophy or herniated saclike skin. Some families with hereditary anetoderma have been described, but there have been no reports on Japanese familial anetoderma so far. We herein report two Japanese sibling cases of primary anetoderma. A healthy 13-year-old Japanese girl and a healthy 15-year-old Japanese girl presented to our hospital with a 6-month history of small atrophic pittings on their arms and trunks. All lesions were less than 0.5 cm in diameter, which are relatively small for non-familial anetoderma. Preceding infections or skin lesions were not observed. A skin biopsy revealed a focal, complete loss of elastic tissue in the superficial to mid-dermis which was surrounded by fine, irregular or twisted elastic fibers. Based on these findings, the diagnosis of anetoderma was made. Review of published works demonstrated that the mode of inheritance of familial anetoderma is not simple, suggesting that it is important to survey any family member of the patients with anetoderma.
Subject(s)
Anetoderma/diagnosis , Medical History Taking , Multifactorial Inheritance , Rare Diseases/diagnosis , Adolescent , Anetoderma/genetics , Anetoderma/pathology , Biopsy , Female , Humans , Japan , Rare Diseases/genetics , Rare Diseases/pathology , Skin/pathologyABSTRACT
With an incidence of 1 in 700 births, Down syndrome (DS) is not an uncommon condition. It is associated with various disorders of different organ systems. Serious disorders include cardiac defects and leukemia. With an onset during the newborn period, the latter does not always progress to classic myeloid leukemia (transient myeloproliferative disorder). Skin manifestations in newborns include pustules/vesiculopustules. In individuals with DS, such lesions should not only prompt suspicion for typical neonatal rashes and infections but also for transient myeloproliferative disorder. However, most dermatoses are benign. They essentially comprise disorders of keratinization that present as xerosis, keratosis pilaris, lichenification, and ichthyosis vulgaris. Also typical but not specific is the four-finger palmar crease (simian crease). Patients frequently develop folliculitides, which - due to elastolysis - subsequently progress to anetoderma. The known immune disturbance in DS patients explains the occurrence of autoimmune diseases such as alopecia areata and vitiligo. Typical skin conditions associated with DS include elastosis perforans serpiginosa, syringomas, milia-like calcinosis cutis, and multiple eruptive dermatofibromas.
Subject(s)
Down Syndrome/diagnosis , Guideline Adherence , Skin Diseases/diagnosis , Abnormalities, Multiple/diagnosis , Abnormalities, Multiple/epidemiology , Adolescent , Adult , Anetoderma/diagnosis , Anetoderma/epidemiology , Autoimmune Diseases/diagnosis , Autoimmune Diseases/epidemiology , Child , Child, Preschool , Comorbidity , Cross-Sectional Studies , Darier Disease/diagnosis , Darier Disease/epidemiology , Down Syndrome/epidemiology , Exanthema/diagnosis , Exanthema/epidemiology , Eyebrows/abnormalities , Female , Germany , Humans , Ichthyosis/diagnosis , Ichthyosis/epidemiology , Ichthyosis Vulgaris/diagnosis , Ichthyosis Vulgaris/epidemiology , Infant , Infant, Newborn , Lichen Planus/diagnosis , Lichen Planus/epidemiology , Male , Myeloproliferative Disorders/diagnosis , Myeloproliferative Disorders/epidemiology , Skin Diseases/epidemiology , Skin Diseases, Infectious/diagnosis , Skin Diseases, Infectious/epidemiology , Young AdultABSTRACT
No disponible
Subject(s)
Humans , Female , Adult , Autoimmune Diseases/complications , Anetoderma/diagnosis , Antiphospholipid Syndrome/diagnosis , Lupus Erythematosus, Systemic/diagnosis , BiopsyABSTRACT
Along with collagen, elastic fibers are integral components of cutaneous connective tissue. A decrease in elastic fibers or loss thereof has been described in a number of clinically distinct skin diseases, both hereditary and acquired. In disorders associated with inflammation, elastophagocytosis is an important histological hallmark. Treatment is generally difficult.
Subject(s)
Elastic Tissue/pathology , Skin Diseases/pathology , Skin/pathology , Anetoderma/diagnosis , Anetoderma/pathology , Anetoderma/therapy , Cutis Laxa/diagnosis , Cutis Laxa/pathology , Cutis Laxa/therapy , Granuloma, Giant Cell , Humans , Keratoderma, Palmoplantar/diagnosis , Keratoderma, Palmoplantar/pathology , Keratoderma, Palmoplantar/therapy , Lymphoma, T-Cell, Cutaneous/diagnosis , Lymphoma, T-Cell, Cutaneous/pathology , Lymphoma, T-Cell, Cutaneous/therapy , Pseudoxanthoma Elasticum , Skin Diseases/diagnosis , Skin Diseases/therapy , Skin Neoplasms/diagnosis , Skin Neoplasms/pathology , Skin Neoplasms/therapySubject(s)
Anetoderma/diagnosis , Pilomatrixoma/diagnosis , Skin Neoplasms/diagnosis , Thoracic Neoplasms/diagnosis , Thoracic Wall , Adolescent , Anetoderma/pathology , Anetoderma/surgery , Diagnosis, Differential , Humans , Male , Pilomatrixoma/pathology , Pilomatrixoma/surgery , Skin/pathology , Skin Neoplasms/pathology , Skin Neoplasms/surgery , Thoracic Neoplasms/pathology , Thoracic Neoplasms/surgery , UltrasonographyABSTRACT
Anetoderma is a rare benign condition of diverse etiology whose characteristic is the diminution or absence of the dermal elastic fibers. Classified as primary and secondary, the latter associated with tumors, inflammatory, and infectious diseases. Although the etiology of the lesions is well described in literature, the pathogenesis is still poorly determined. Anetoderma in syphilis is rare, and occurs even in the most uncommon cutaneous manifestations of the disease, such as the nodular form. In order to better understand the changes that lead to elastolysis, we propose a better correlation with the histopathological findings of the lesions that precede it. We present two cases of anetoderma secondary to syphilis, whose clinical aspects resembled the pattern of their initial secondary syphilis rash.
Subject(s)
Anetoderma/drug therapy , Anetoderma/etiology , Elastic Tissue/pathology , Penicillin G Benzathine/therapeutic use , Syphilis/complications , Adult , Anetoderma/diagnosis , Anetoderma/pathology , Biopsy , Female , Humans , Penicillin G Benzathine/adverse effects , Skin/pathology , Skin Diseases , Syphilis/pathology , TherapeuticsABSTRACT
INTRODUCTION: Anetoderma is an elastolytic skindisorder that has been associated with the presenceof antiphospholipid antibodies (aPL). Patients withantiphospholipid antibody-positive anetoderma havebeen reported to develop symptoms of Graves disease,antiphospholipid syndrome, and other autoimmuneconditions. The temporal relationship, however,between anetoderma onset and the emergence ofaPL remains unclear, a clarification of which may haveimplications for the screening and monitoring ofpatients with anetoderma. CASE: Herein we report acase of a patient with systemic lupus erythematosuspresenting with anetoderma that preceded thedevelopment of aPL. The patient was found to havesubsequently developed IgM cardiolipin antibodiesat a serology follow-up approximately two years later.Conclusion and Relevance: This finding suggests thatanetoderma can precede aPL seroconversion andthat patients with anetoderma may require continuedserology monitoring. Such long-term monitoring willbe important for identifying laboratory indicationsthat may portend the development of furtherautoimmune symptoms associated with anetoderma.
Subject(s)
Anetoderma/immunology , Antibodies, Anticardiolipin/immunology , Immunoglobulin M/immunology , Lupus Erythematosus, Systemic/immunology , Anetoderma/complications , Anetoderma/diagnosis , Anetoderma/pathology , Antibodies, Antiphospholipid/immunology , Elbow , Female , Humans , Lupus Erythematosus, Systemic/complications , Time Factors , Young AdultABSTRACT
Pilomatricoma is a benign cutaneous tumor originatingfrom hair matrix cells. Anetodermic changes inthe skin overlying pilomatricomas are sometimesreported, although their precise mechanisms remainunknown. We present an unusual case of anetodermicpilomatricoma on the upper extremity of a 17-yearoldboy and report its clinical, histopathologic, andsonographic findings.
Subject(s)
Anetoderma/diagnosis , Calcinosis/diagnosis , Hair Diseases/diagnosis , Pilomatrixoma/diagnosis , Skin Neoplasms/diagnosis , Adolescent , Anetoderma/diagnostic imaging , Anetoderma/pathology , Anetoderma/surgery , Arm , Calcinosis/diagnostic imaging , Calcinosis/pathology , Calcinosis/surgery , Hair Diseases/diagnostic imaging , Hair Diseases/pathology , Hair Diseases/surgery , Humans , Male , Pilomatrixoma/diagnostic imaging , Pilomatrixoma/pathology , Pilomatrixoma/surgery , Skin Neoplasms/diagnostic imaging , Skin Neoplasms/pathology , Skin Neoplasms/surgery , UltrasonographyABSTRACT
Anetoderma is a rare benign elastolytic disorder that is characterized by focal loss of elastin fibers on histopathology and is often recalcitrant to treatment. We present a case of a patient with a 20-year history of pruritic and painful hyperpigmented atrophic papules clustered on the neck, axillae, inframammary folds, and right medial thigh. Although the histopathologyof her axillary lesions was consistent with anetoderma, her clinical presentation is unusual given the extent of involvement, reported pain and pruritus, and sharp demarcation of the distribution. The diagnosticuncertainty of this case led to added difficulty in management of a disease that is already notoriously difficult to treat and may significantly impact patient's quality of life.
Subject(s)
Anetoderma/diagnosis , Undifferentiated Connective Tissue Diseases/diagnosis , Anetoderma/complications , Anetoderma/pathology , Anetoderma/therapy , Delayed Diagnosis , Female , Humans , Middle Aged , Undifferentiated Connective Tissue Diseases/complications , Undifferentiated Connective Tissue Diseases/pathologyABSTRACT
No disponible
Subject(s)
Humans , Adult , Anetoderma/diagnosis , Elastic Tissue/physiopathology , Risk Factors , Biomarkers/analysis , Protein S Deficiency/diagnosisABSTRACT
La anetodermia es un trastorno elastolítico infrecuente, caracterizado clínicamente por áreas de piel laxa y pérdida o disminución de las fibras elásticas en la histología. Este hallazgo sin enfermedad cutánea previa es conocido como anetodermia primaria y se suele asociar a enfermedades autoinmunes; dentro de éstas el lupus eritematoso sistémico (LES), con anticuerpos antifosfolipídicos, y el síndrome antifosfolipídico (SAF) son las más frecuentes. Presentamos una paciente con anetodermia primaria, LES y anticuerpos antifosfolipídicos positivos sin clínica de SAF (AU)
Anetoderma is an infrequent elastolytic disorder, clinically characterized by areas with lack of the skin and decreased elastic fibers at histology. This finding without previous skin disease is known as primary anetoderma and is often associated with autoimmune diseases such as systemic lupus erythematosus (SLE), with antiphospholipid antibodies, and antiphospholipid syndrome (APS). A female patient with primary anetoderma, SLE and positive antiphospholipid antibodies without clinical APS is reported (AU)
Subject(s)
Humans , Female , Adult , Anetoderma/diagnosis , Lupus Erythematosus, Systemic/complications , Antiphospholipid SyndromeABSTRACT
Elastophagocytosis is the engulfment of the elastic fibres by the histiocytes, multinucleated giant cells, or both. The cutaneous lesions showing elastophagocytosis are annular elastolytic giant cell granuloma, actinic keratoses, persistent insect-bite reactions, elastosis perforans serpiginosa, foreign body granuloma. Occasionally, it may occur in infectious diseases like leprosy, granulomatous syphilis, North-American blastomycosis, bacterial folliculitis, and cutaneous leishmaniasis. We report a case of lepromatous leprosy with necrotic erythema nodosum leprosum with secondary anetoderma. Histopathology from the atrophic macule of anetoderma revealed periappendageal, perineural infiltration, elastophagocytosis and reduction in elastic fibres.