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2.
Eur Arch Otorhinolaryngol ; 281(6): 3279-3281, 2024 Jun.
Article in English | MEDLINE | ID: mdl-38536492

ABSTRACT

BACKGROUND: Angiokeratoma is a rare cutaneous presentation with unknown etiology. CASE PRESENTATION: A case of a 10-year male, who was presented to the ENT OPD with a swelling over the posterior aspect of the tongue. The chief complaints included growth on the right side of the posterior third of the tongue which was extending up to the base of the tongue on the same side. CONCLUSION: Excisional biopsy was taken and sent for histopathology which was suggestive of inflamed angiokeratoma. Post-excision there is no recurrence till date.


Subject(s)
Angiokeratoma , Tongue Neoplasms , Humans , Male , Angiokeratoma/pathology , Angiokeratoma/diagnosis , Tongue Neoplasms/pathology , Tongue Neoplasms/surgery , Tongue Neoplasms/diagnosis , Child , Biopsy
11.
Dermatol Online J ; 27(8)2021 Aug 15.
Article in English | MEDLINE | ID: mdl-34755962

ABSTRACT

We describe a patient with leukemia undergoing chemotherapy who developed painful purpuric nodules of the digits. These findings were concerning for endocarditis (clinically) and angiokeratomas on gross histology. After extensive evaluation, we report the development of painful purpuric nodules as a likely side effect of the patient's therapeutic regimen (hydroxyurea, danorubicin, cytarabine, and methotrexate).


Subject(s)
Angiokeratoma/chemically induced , Antineoplastic Combined Chemotherapy Protocols/adverse effects , Hand Dermatoses/chemically induced , Leukemia/drug therapy , Purpura/chemically induced , Skin Neoplasms/chemically induced , Angiokeratoma/diagnosis , Cytarabine/administration & dosage , Daunorubicin/administration & dosage , Diagnosis, Differential , Female , Hand Dermatoses/diagnosis , Humans , Hydroxyurea/administration & dosage , Methotrexate/administration & dosage , Middle Aged , Purpura/diagnosis , Purpura/pathology , Skin Neoplasms/diagnosis
12.
Ned Tijdschr Tandheelkd ; 128(9): 429-433, 2021 Sep.
Article in Dutch | MEDLINE | ID: mdl-34490767

ABSTRACT

A 41-year-old woman, who was referred with a reddish purple like lesion on the left side of the tongue, appeared to have an angiokeratoma after histopathological examination. Because of the benign character of this lesion and the absence of any complaints, no adjuvant treatment after excisional biopsy was indicated. Angiokeratomas rarely appear as solitary oral lesions. More often they are seen as part of an underlying systemic disease, mostly Fabry disease. Due to widespread skin involvement of angiokeratomas with Fabry disease, referral to a dermatologist is indicated when oral lesions are encountered. Esthetically unpleasing or painful angiokeratomas can be locally excised or treated by laser- or cryotherapy.


Subject(s)
Angiokeratoma , Skin Neoplasms , Adult , Angiokeratoma/diagnosis , Biopsy , Female , Humans , Skin Neoplasms/diagnosis , Tongue
13.
Skinmed ; 19(3): 216-218, 2021.
Article in English | MEDLINE | ID: mdl-34303393

ABSTRACT

Genital rejuvenation requires medical and procedural treatments that can improve the morphology or aesthetics of the scrotum and vagina. Angiokeratomas are benign vascular lesions that my occur on the penis, scrotum, and vulva. These lesions can be of either cosmetic concern or medical significance if they bleed. Laser therapy can be successfully utilized for the treatment of genital angiokeratomas in men and women.


Subject(s)
Angiokeratoma , Genital Diseases, Male , Laser Therapy , Skin Neoplasms , Vulvar Diseases , Angiokeratoma/therapy , Female , Genital Diseases, Male/therapy , Humans , Male , Rejuvenation , Scrotum/pathology , Vulva , Vulvar Diseases/therapy
16.
Acta Dermatovenerol Croat ; 29(3): 169-170, 2021 Dec.
Article in English | MEDLINE | ID: mdl-34990348

ABSTRACT

Dear Editor, A 45-year-old man presented with a large, dark, keratotic, warty, and friable plaque on the distal posterior aspect of the left leg (Figure 1, a). The patient reported that the lesion was not present at birth but had appeared approximately at the age of three as an erythematous patch that progressively grew over the time. During adolescence, the surface of the lesion became rough and warty and was easily traumatized due to its location, resulting in recurrent bleeding episodes over a period of years. For this reason, the patient requested lesion removal. The patient did not report any other significant comorbidity, and physical examination revealed no other abnormalities. A shaving biopsy of the lesion was performed, and histopathology highlighted ectatic vascular spaces with some luminal red blood cell beneath a papillomatous and hyperkeratotic epidermis (Figure 1, b). Based on clinical and histopathological features, a diagnosis of angiokeratoma circumscriptum naeviforme (ACN) was established. ACN is one of the five disorders belonging to the group of angiokeratomas (AKs) that also include AK of Mibelli, AK of Fordyce, solitary or multiple AK, and AK corporis diffusum. Among these variants, ACN is the rarest and is seldom studied (1). AKs are benign vascular anomalies of the superficial vascular plexus that appear as dark red papules and plaques arranged either discretely or in clusters. ACN lesions are typically situated unilaterally on the lower limbs, especially on the legs and feet, but can occasionally occur elsewhere. Lesions are generally noted in early childhood. The early lesions are flat and reddish in color, while older lesions become increasingly studded and acquire a verrucous or warty surface. There is no tendency of spontaneous improvement, and minor traumas can easily cause beading and infection (2). While the plaques were linear in disposition in most of the cases reported in the literature, a peculiar feature of our case was the isolated, round, and giant appearance of the plaque. Even though ACN is not typically associated with other abnormalities, coexistence with other vascular malformations has been reported in some cases, including AK of Fordyce, Cobb syndrome, Klippel-Trenaunay syndrome, nevus flammeus, infantile hemangioma, and traumatic arteriovenous fistula (3). From a histological point of view, ACN appears as dilated dermal papillary capillaries drained by dilated venules. The overlying epidermis shows a variable degree of acanthosis, papillomatosis, and compact hyperkeratosis. Typically, the deep dermis and hypodermis are not involved, helping distinguish them from verrucous hemangioma (4). Lichen simplex chronicus, verrucous carcinoma, and verrucous melanoma must also be considered in the differential diagnosis (5). Recurrent bleeding or cosmetic reasons are common indications for treatment. Surgical excision represents the most effective option. Other possibilities include diathermy, electrocautery, cryosurgery, or laser (6). In our case, there was no macroscopic residual disease after the shaving biopsy. A collagen dressing was applied, and the wound underwent second intention healing in three weeks. There was no evidence of local recurrence after 18 months. References: Das A, Mondal AK, Saha A, Chowdhury SN, Gharami RC. Angiokeratoma circumscriptum neviforme: An entity, few and far between. Indian Dermatol Online J. 2014;5:472-4. Mittal R, Aggarwal A, Srivastava G. Angiokeratoma circumscriptum: a case report and review of the literature. Int J Dermatol. 2005;44:1031-4. Wankhade V, Singh R, Sadhwani V, Kodate P, Disawal A. Angiokeratoma circumscriptum naeviforme with soft tissue hypertrophy and deep venous malformation: A variant of Klippel-Trenaunay syndrome? Indian Dermatol Online J. 2014;5(Suppl 2):S109-S112. Oppermann K, Boff AL, Bonamigo RR. Verrucous hemangioma and histopathological differential diagnosis with angiokeratoma circumscriptum neviforme. An Bras Dermatol. 2018;93:712-5. Goldman L, Gibson SH, Richfield DF. Thrombotic angiokeratoma circumscriptum simulating melanoma. Arch Dermatol. 1981;117:138-9. del Pozo J, Fonseca E. Angiokeratoma circumscriptum naeviforme: successful treatment with carbon-dioxide laser vaporization. Dermatol Surg. 2005;31:232-6.


Subject(s)
Angiokeratoma , Hemangioma , Papilloma , Skin Neoplasms , Angiokeratoma/diagnosis , Child, Preschool , Humans , Leg , Male , Middle Aged , Skin Neoplasms/diagnosis
17.
J Clin Rheumatol ; 27(8S): S788, 2021 Dec 01.
Article in English | MEDLINE | ID: mdl-32604242
19.
Dermatol Online J ; 26(11)2020 Nov 15.
Article in English | MEDLINE | ID: mdl-33342183

ABSTRACT

Angiokeratoma circumscriptum is the rarest variant of angiokeratoma. It usually affects females and it is characterized by dark-red to blue-black confluent papules or nodules on lower limbs in a segmental and unilateral distribution. We describe the clinical and histopathological findings in a patient with angiokeratoma circumscriptum and discuss the etiology, associations, diagnosis, differential diagnosis, and treatment.


Subject(s)
Angiokeratoma/diagnosis , Skin Neoplasms/diagnosis , Adult , Angiokeratoma/congenital , Angiokeratoma/pathology , Diagnosis, Differential , Female , Humans , Lower Extremity , Skin Neoplasms/congenital , Skin Neoplasms/pathology
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