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2.
J Small Anim Pract ; 57(10): 543-547, 2016 Oct.
Article in English | MEDLINE | ID: mdl-27467420

ABSTRACT

OBJECTIVES: To compare cold compression therapy, modified Robert-Jones bandage or the combination of cold compression therapy plus modified Robert-Jones bandage on operated limbs following tibial plateau levelling osteotomy in dogs. METHODS: Twenty-one client-owned dogs with cranial cruciate ligament disease were prospectively enrolled. Dogs were randomly assigned to one of three postoperative treatment groups: cold compression therapy, modified Robert-Jones bandage or a combination of both. Patients were evaluated preoperatively and at 12, 24 and 36 hours following tibial plateau levelling osteotomy. Measurements included weight-bearing on the operated limb, stifle flexion and extension angles and circumference of the operated limb at four levels. RESULTS: There was no significant difference in weight-bearing, range of motion or limb swelling between groups. There was a trend for dogs in the cold compression therapy and cold compression therapy with a bandage groups to have a greater increase in weight-bearing after surgery compared with the bandage-only group. CLINICAL RELEVANCE: Cold compression therapy is a safe modality following tibial plateau levelling osteotomy surgery. The trend towards improved use of the operated limb in the groups receiving cold compression therapy compared with those treated with only a bandage may be an indication that these patients are more comfortable in the postoperative period. The small sample size limits interpretation of the data but this pilot study provides data to guide future investigation.


Subject(s)
Anterior Cruciate Ligament Reconstruction/veterinary , Bandages/veterinary , Compression Bandages/veterinary , Cryotherapy/veterinary , Dog Diseases/therapy , Osteotomy/veterinary , Animals , Dog Diseases/surgery , Dogs , Joint Diseases/surgery , Joint Diseases/therapy , Joint Diseases/veterinary , Pilot Projects , Range of Motion, Articular , Stifle , Weight-Bearing
3.
Vet Surg ; 45(2): 261-8, 2016 Feb.
Article in English | MEDLINE | ID: mdl-26768085

ABSTRACT

OBJECTIVE: To determine a long term function of tibial tuberosity advancement (TTA) for treatment of ruptured cranial cruciate ligament (CCL) in dogs, and to compare this to the long term function of previously reported tibial plateau leveling osteotomy (TPLO), extracapsular reconstruction (ECR), and a population of normal dogs. STUDY DESIGN: Prospective clinical trial. ANIMALS: Dogs with unilateral ruptured CCL treated with TTA (n = 14), TPLO (n = 15), and ECR (n = 23), and normal adult dogs (control, n = 80). MATERIALS AND METHODS: Force plate gait analysis was performed at 1 time point for the normal control group and preoperatively, and at 2 and 8 weeks and 6 and 12 months postoperatively for the treatment groups. Using serial force plates, symmetry indices (SI) were calculated between the operated and unoperated pelvic limbs for peak vertical force (PVF), contact time (CT), and vertical impulse (VI). Ground reaction forces (GRF) of the treatment and control group were compared using a general linear model. RESULTS: Walk SI for dogs with TTA were not significantly different from the control group at 12 months postoperatively. At the trot, neither TTA nor ECR achieved normal GRF. SI of the TPLO group were not different from the normal control group by 6-12 months postoperatively. CONCLUSION: At the walk, TTA achieves normal function by 12 months; however, at the trot TTA is indistinguishable from ECR. TPLO resulted in operated limb function that was similar to the control population by 6-12 months postoperatively at the walk and the trot.


Subject(s)
Anterior Cruciate Ligament Injuries , Dogs/injuries , Tibia/surgery , Animals , Anterior Cruciate Ligament/surgery , Anterior Cruciate Ligament Reconstruction/veterinary , Dogs/surgery , Female , Male , Osteotomy/veterinary , Prospective Studies , Recovery of Function
4.
Article in English | MEDLINE | ID: mdl-26333277

ABSTRACT

OBJECTIVE: To develop and test an arthroscopic aiming device for extra- to intra-articular femoral tunnel drilling emerging at the center of the femoral insertion of the cranial cruciate ligament (CrCL) in medium to large breed dogs. MATERIAL AND METHODS: Hindlimbs (n = 12) of six cadaveric dogs (≥ 20 kg bodyweight). One hindlimb from each cadaver was randomly chosen. On a standard medio-lateral stifle radiograph the caudo-cranial position of the CrCL center was measured and transferred onto an adjustable aiming device. After arthroscopic debridement of the CrCL the aiming device was hooked behind the lateral condyle and a 2.4 mm guide pin was placed from extra- to intra-articular. The intra-articular position of the resulting bone tunnel was evaluated radiographically as well as compared to the anatomic CrCl center of the contralateral hindlimb using 3D renderings. RESULTS: According to the postoperative radiographs all six drill tunnels were located at or near the CrCL center. The median absolute 3D error from the anatomical center of the CrCL was 0.6 mm (range: 0.2-0.9 mm). CONCLUSION: Precise anatomic placement of the femoral tunnel for intra-articular repair of the CrCL was achieved using an adjustable aiming device. CLINICAL RELEVANCE: The proposed technique will reduce femoral tunnel misplacement when performing intra-articular CrCL repair in dogs. In combination with the published technique for arthroscopic tibial tunnel drilling using a similar aiming device, the technical requirements for arthroscopic assisted tunnel positioning for anatomical graft replacement are available.


Subject(s)
Anterior Cruciate Ligament Reconstruction/veterinary , Anterior Cruciate Ligament/surgery , Arthroscopy/veterinary , Dogs/surgery , Femur/surgery , Stifle/surgery , Animals , Anterior Cruciate Ligament Reconstruction/instrumentation , Anterior Cruciate Ligament Reconstruction/methods , Arthroscopy/instrumentation , Arthroscopy/methods , Equipment Design
5.
Vet Comp Orthop Traumatol ; 26(1): 42-6, 2013.
Article in English | MEDLINE | ID: mdl-23154786

ABSTRACT

OBJECTIVES: To evaluate and compare detection of meniscal tears associated with cranial cruciate ligament insufficiency by either arthroscopy or arthrotomy. METHODS: A retrospective, cohort study was completed with stifles (n = 531) of dogs with cranial cruciate ligament rupture. Either a medial parapatellar arthrotomy or an arthroscopy procedure was performed and groups were compared for significant differences in meniscal tears detected using logistic regression analysis. RESULTS: Arthroscopy was performed on 58.8% and arthrotomy on 41.2% of the stifles. In total, 44.4% of the examined stifles had meniscal tears. Meniscal tears were found in 38.8% of the stifles examined by arthrotomy, and 48.4% of those examined by arthroscopy. Overall, the rate of detection of a meniscal tear was significantly different (p = 0.019) between the groups, and meniscal tears were observed more frequently by arthroscopy than by arthrotomy (odds ratio 1.54; 95% confidence interval 1.07 - 2.22). CLINICAL SIGNIFICANCE: These results suggest that arthroscopy may be more sensitive than arthrotomy for detection of meniscal pathology in clinical patients. However, these results must be interpreted with caution since this was a retrospective study. Randomized prospective clinical studies are required to further test this hypothesis.


Subject(s)
Anterior Cruciate Ligament Reconstruction/veterinary , Arthroscopy/veterinary , Menisci, Tibial/pathology , Animals , Anterior Cruciate Ligament/surgery , Anterior Cruciate Ligament Injuries , Anterior Cruciate Ligament Reconstruction/methods , Cartilage, Articular/injuries , Cartilage, Articular/surgery , Dog Diseases , Dogs , Female , Logistic Models , Male , Retrospective Studies , Rupture
6.
Int J Mol Sci ; 13(10): 13605-20, 2012 Oct 22.
Article in English | MEDLINE | ID: mdl-23202970

ABSTRACT

At present, due to the growing attention focused on the issue of tendon-bone healing, we carried out an animal study of the use of genetic intervention combined with cell transplantation for the promotion of this process. Here, the efficacy of bone marrow stromal cells infected with bone morphogenetic protein-2 (BMP-2) on tendon-bone healing was determined. A eukaryotic expression vector containing the BMP-2 gene was constructed and bone marrow-derived mesenchymal stem cells (bMSCs) were infected with a lentivirus. Next, we examined the viability of the infected cells and the mRNA and protein levels of BMP-2-infected bMSCs. Gastrocnemius tendons, gastrocnemius tendons wrapped by bMSCs infected with the control virus (bMSCs+Lv-Control), and gastrocnemius tendons wrapped by bMSCs infected with the recombinant BMP-2 virus (bMSCs+Lv-BMP-2) were used to reconstruct the anterior cruciate ligament (ACL) in New Zealand white rabbits. Specimens from each group were harvested four and eight weeks postoperatively and evaluated using biomechanical and histological methods. The bMSCs were infected with the lentivirus at an efficiency close to 100%. The BMP-2 mRNA and protein levels in bMSCs were significantly increased after lentiviral infection. The bMSCs and BMP-2-infected bMSCs on the gastrocnemius tendon improved the biomechanical properties of the graft in the bone tunnel; specifically, bMSCs infected with BMP-2 had a positive effect on tendon-bone healing. In the four-week and eight-week groups, bMSCs+Lv-BMP-2 group exhibited significantly higher maximum loads of 29.3 ± 7.4 N and 45.5 ± 11.9 N, respectively, compared with the control group (19.9 ± 6.4 N and 21.9 ± 4.9 N) (P = 0.041 and P = 0.001, respectively). In the eight-week groups, the stiffness of the bMSCs+Lv-BMP-2 group (32.5 ± 7.3) was significantly higher than that of the bMSCs+Lv-Control group (22.8 ± 7.4) or control groups (12.4 ± 6.0) (p = 0.036 and 0.001, respectively). Based on the histological findings, there was an increased amount of perpendicular collagen fibers formed between the tendon and bone in the bMSCs+Lv-Control and bMSCs+Lv-BMP-2 group, compared with the gastrocnemius tendons. The proliferation of cartilage-like cells and the formation of fibrocartilage-like tissue were highest within the bone tunnels in the bMSCs+Lv-BMP-2 group. These results suggest that this lentivirus can be used to efficiently infect bMSCs with BMP-2. Furthermore, tendons wrapped by bMSCs+Lv-BMP-2 improved tendon-bone healing.


Subject(s)
Anterior Cruciate Ligament Reconstruction , Bone Marrow Cells/cytology , Bone Morphogenetic Protein 2/metabolism , Mesenchymal Stem Cells/cytology , Wound Healing , Animals , Anterior Cruciate Ligament Reconstruction/veterinary , Bone Morphogenetic Protein 2/genetics , Bone and Bones/pathology , Cell Differentiation , Cell Survival , Cells, Cultured , Genetic Vectors/metabolism , Lentivirus/genetics , Mesenchymal Stem Cell Transplantation , Mesenchymal Stem Cells/metabolism , RNA, Messenger/metabolism , Rabbits , Tendons/pathology , Transfection , Transplantation, Homologous
7.
J Am Vet Med Assoc ; 240(12): 1481-7, 2012 Jun 15.
Article in English | MEDLINE | ID: mdl-22657932

ABSTRACT

OBJECTIVE: To describe the surgical and postoperative complications encountered with tibial tuberosity advancement (TTA) performed in dogs with cranial cruciate ligament-deficient stifle joints. DESIGN: Retrospective case series. ANIMALS: 458 dogs (TTA performed on 501 stifle joints). PROCEDURES: During the 2-year period, 624 TTA procedures had been performed in dogs for correction of cranial cruciate ligament deficiency. Five hundred one stifle joints in 458 dogs fit the criteria for inclusion; 43 dogs had had TTAs performed on both stifle joints. Historical data and complications reported were analyzed. RESULTS: Following 501 TTA surgeries, there were 95 instances of complications reported. In 7 stifle joints, 2 complications occurred. The most common complication was incisional infection and inflammation. Stifle joints with medial menisci that did not undergo medial meniscal release had a high incidence of subsequent injury, and meniscal tear was the most common complication treated by a second surgery. A partially torn cranial cruciate ligament left in situ at the time of TTA did not protect against subsequent injury of an intact, unreleased medial meniscus. Most fractures were identified on routine follow-up radiography and were rarely treated. In terms of preoperative factors, high body weight (> 40 kg [88 lb]) and a high preoperative patellar tendon angle were significantly associated with complications. CONCLUSIONS AND CLINICAL RELEVANCE: High body weight and preoperative patellar tendon angle were significantly associated with complications following TTA in dogs. Subsequent meniscal tear was the most common reason for second surgery, suggesting that medial meniscal release of intact menisci should be considered when performing TTA in dogs.


Subject(s)
Anterior Cruciate Ligament Injuries , Anterior Cruciate Ligament Reconstruction/veterinary , Anterior Cruciate Ligament/surgery , Dog Diseases/epidemiology , Dogs , Postoperative Complications/veterinary , Animals , Dogs/injuries , Dogs/surgery , Female , Male , Postoperative Complications/epidemiology , Retrospective Studies , Risk Factors , Rupture/veterinary , Stifle/pathology , Stifle/surgery , Surgical Wound Infection/epidemiology , Surgical Wound Infection/veterinary , Tibia/pathology , Tibia/surgery , Treatment Outcome
8.
Rev. esp. cir. ortop. traumatol. (Ed. impr.) ; 56(3): 216-223, mayo-jun. 2012.
Article in Spanish | IBECS | ID: ibc-100224

ABSTRACT

Objetivo. Estudiar la integración de una plastia tendinosa en la reparación de un ligamento cruzado anterior (LCA) y el proceso de «ligamentización» con túneles de diferente calibre. Material y métodos. Estudiamos la integración del LCA en 41 ovejas adultas, según los siguientes grupos: grupo A: plastia tendinosa autóloga del tendón flexor superficial de la pezuña en túnel femoral y tibial de 5mm de diámetro; grupo B: en túneles de 7mm de diámetro. Sacrificio a los 3, 6 y 12 meses. Efectuamos un estudio histológico de la plastia en el túnel femoral, en el túnel tibial e intraarticular. También analizamos biomecánicamente el complejo fémur-plastia-tibia, con túneles de diferente diámetro y distintos tiempos de evolución. Resultados. En los túneles de 5mm no vimos integración directa de la plastia con el hueso. Observamos un tejido fibroso celular y vascularizado. En los túneles de 7mm tampoco observamos unión directa de la plastia con el hueso. El tejido de interfaz era un tejido fibroso con una estructura fascicular desarrollando la formación de septos y penetración de vasos. Macroscópicamente la plastia seguía recordando al tendón original. Las plastias de túnel de 7mm y con mayor tiempo de evolución necesitaban más fuerza de rotura y presentaban mayor elongación que las plastias de túneles de 5mm. Conclusión. Histológicamente, al año de evolución, el tendón no se transformó en un ligamento y no había integración de la plastia con el hueso de los túneles, independientemente del diámetro de éstos (AU)


Objective. To analyse the bone-ligament integration «ligamentization» of the tendon graft in the reconstruction of anterior cruciate ligament (ACL) performing tunnels of different diameter. Material and methods. We performed the same reconstruction procedure using an autologous tendon graft taken from the superficial tendon of the hoof in 41 adult sheep. In Group A the tibial and femoral tunnels were 5mm in diameter and in Group B they were 7mm in diameter. The sheep were sacrificed at 3, 6 and 12 months after the surgery. Histological studies were performed on the graft and the tunnels, as well as a biomechanical analysis of the tibial-femoral complex. Results. In group A we did not observe direct integration of the bone and the tendon graft or any fibres joining both structures, although there was vascularized fibrous tissue. In group B we did not observe any direct binding of the bone and the tendon graft either, although there was abundant fibrous tissue. The tendon graft showed a fascicular structure that increased over time in order to create septa for vascular penetration. Macroscopically the ACL graft had a dense appearance, which was very similar to the original tendon graft. The tendon grafts from group B and with a longer follow up period required a higher strength to produce maximum breakage than the tendon grafts from group A. Conclusion. After one year follow up, the histological study shows that the tendon graft is not transformed into a ligament, and there is no integration of the tendon graft in tunnels regardless of their diameter. Therefore, fixation techniques are essential to maintain the orientation and tension of the tendon graft (AU)


Subject(s)
Animals , Male , Female , Sheep/abnormalities , Sheep/surgery , Tendon Transfer/methods , Tendon Transfer/veterinary , Anterior Cruciate Ligament/pathology , Anterior Cruciate Ligament/surgery , Anterior Cruciate Ligament Reconstruction/methods , Anterior Cruciate Ligament Reconstruction/veterinary , Implants, Experimental , Implants, Experimental/veterinary , Anterior Cruciate Ligament/physiopathology , Anterior Cruciate Ligament , Anterior Cruciate Ligament Reconstruction
9.
Vet Comp Orthop Traumatol ; 25(1): 11-21, 2012.
Article in English | MEDLINE | ID: mdl-22105153

ABSTRACT

OBJECTIVES: To compare the improvement in degree of lameness following surgical repair of cranial cruciate ligament rupture in dogs using computer-assisted gait analysis. METHODS: Two groups of 14 dogs were used. One group was treated by a capsular-fascial imbrication method, and the other group by tibial plateau levelling osteotomy (TPLO). All dogs underwent gait analysis prior to surgery, as well as at four days, four weeks, and four months after surgery. Symmetry indices of vertical ground reaction forces as well as vertical ground reaction forces in % body weight, joint angles and certain gait cycle parameters were evaluated. RESULTS: Four months after surgery, the degree of lameness expressed as symmetry index for peak vertical force for the TPLO group (5.83%) was not significantly different to the capsular-fascial imbrication group (19.05%). Within the TPLO group, there was a significantly increased ability to extend the stifle joint four months after surgery. The stifle motion pattern of the capsular-fascial imbrication group as well as the range-of-motion in both groups showed very little change at the time of the last gait analysis. The complication rate was greater in the TPLO group than in the capsular-fascial group. CLINICAL SIGNIFICANCE: In conclusion the results suggest that the TPLO method leads to a faster recovery and improved limb function in comparison to the capsular-fascial imbrication method four months after surgery. Further analyses are needed to determine if the TPLO method is superior concerning long-term joint stability.


Subject(s)
Anterior Cruciate Ligament Injuries , Anterior Cruciate Ligament Reconstruction/veterinary , Anterior Cruciate Ligament/surgery , Gait , Image Processing, Computer-Assisted , Animals , Anterior Cruciate Ligament Reconstruction/methods , Dogs , Female , Lameness, Animal , Male , Range of Motion, Articular , Rupture/surgery , Rupture/veterinary , Treatment Outcome
10.
Compend Contin Educ Vet ; 32(10): E1-10; quiz E11, 2010 Oct.
Article in English | MEDLINE | ID: mdl-21308661

ABSTRACT

Meniscal damage is common in dogs with naturally occurring rupture of the cranial cruciate ligament (CrCL). Appropriate diagnosis and treatment of meniscal injuries is critical to avoid chronic lameness in these patients. Given the frequency, expense, and clinical importance of meniscal injuries, a thorough understanding of the meniscus is important for general practitioners and veterinary surgeons alike. Research over the past 7 years has produced an abundance of new information regarding the importance of meniscal pathology, diagnostic methods, and potential treatment options at the time of CrCL surgery. This manuscript highlights recent advances that can benefit clinical practitioners and summarizes research developments that promise new therapies in the near future.


Subject(s)
Anterior Cruciate Ligament Injuries , Dogs/injuries , Tibial Meniscus Injuries , Animals , Anterior Cruciate Ligament/surgery , Anterior Cruciate Ligament Reconstruction/veterinary , Diagnosis, Differential , Dogs/surgery , Menisci, Tibial/surgery , Rupture/veterinary , Treatment Outcome
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