ABSTRACT
A new antitumor antibiotic porothramycin was produced by a new strain of Streptomyces albus. The antibiotic was isolated in two active forms, the natural free hydroxyl form (porothramycin A) or the crystalline methyl ether form (porothramycin B) depending upon the isolation process used. Structural studies established that porothramycin is a new member of the pyrrolo[1,4]benzodiazepine group antibiotics having only one substituent on the benzene ring. The antibiotic exhibited antimicrobial activity against Gram-positive bacteria and anaerobes and significantly prolonged the survival times of mice implanted with experimental tumors.
Subject(s)
Anthramycin/isolation & purification , Antibiotics, Antineoplastic/isolation & purification , Benzodiazepinones/isolation & purification , Animals , Anthramycin/analogs & derivatives , Anthramycin/pharmacology , Antibiotics, Antineoplastic/pharmacology , Chemical Phenomena , Chemistry , Gram-Positive Bacteria/drug effects , Hydrolysis , Leukemia L1210/drug therapy , Leukemia P388/drug therapy , Magnetic Resonance Spectroscopy , Melanoma, Experimental/drug therapy , Mice , Microbial Sensitivity Tests , Streptomyces/metabolismABSTRACT
A new antibiotic, abbeymycin, has been isolated from Streptomyces sp. AB-999F-52. The structure of abbeymycin was assigned on the basis of NMR, mass spectrometric and UV spectral data. Abbeymycin has weak activity against a limited number of anaerobic bacteria.
Subject(s)
Anti-Bacterial Agents/isolation & purification , Streptomyces/analysis , Anthramycin/analogs & derivatives , Anthramycin/isolation & purification , Chemical Phenomena , Chemistry , Magnetic Resonance Spectroscopy , Microbial Sensitivity TestsABSTRACT
The taxonomic description of Streptomyces spadicogriseus, a new species belonging to the Gray Series of streptomycetes as classified by Pridham and Tresner, is presented. This new species is distinguishable from the known members of the Gray Series. Streptomyces spadicogriseus produces anthramycin but bears no taxonomic relation to the known producer of the antibiotic: S. refuineus var. thermotolerans.
