ABSTRACT
Based on the findings from the examination of 133 patients with stable angina pectoris, it was shown that He-Ne laser therapy with the irradiation being applied to the liver projection area in combination with the prolonged-action nitrates is superior to similar application of irradiation to the precordial region and Head's zones or intravenous irradiation of blood. Revealed in the examination of the above patients was a reaction of antiproteolytic enzymes to He-Ne laser therapy, which appeared to be varying with methods of laser therapy. It is suggested that a reaction of the realization of the components of proteolysis might be involved in the realization of therapeutic effect of the He-Ne laser energy in patients with ischemic heart disease.
Subject(s)
Angina Pectoris/radiotherapy , Laser Therapy , Angina Pectoris/drug therapy , Angina Pectoris/metabolism , Antithrombin III/metabolism , Antithrombin III/radiation effects , Chronic Disease , Combined Modality Therapy , Evaluation Studies as Topic , Humans , Liver/metabolism , Liver/radiation effects , Nitroglycerin/therapeutic use , Vasodilator Agents/therapeutic use , alpha 1-Antitrypsin/metabolism , alpha 1-Antitrypsin/radiation effects , alpha-Macroglobulins/metabolism , alpha-Macroglobulins/radiation effectsABSTRACT
The relationship of ischaemic heart disease (IHD) to seasonal and latitude variation has prompted speculation that exposure to the ultraviolet component of solar radiation may reduce IHD risk. This hypothesis was partially tested by exposing 14 post-myocardial infarction patients to a 6 week course of artificial whole-body ultraviolet radiation (UVR). Serum lipoprotein and plasma coagulation factor concentrations were measured before and after the course of UVR. Results were compared with similar measurements from a placebo-controlled group of 13 post-myocardial patients. Despite a more than two-fold rise in mean serum 25-OHD, serum lipoprotein and plasma fibrinogen, antithrombin III and plasminogen concentrations did not change significantly in the UVR group. Significant but minor change in prothrombin time and thrombin time in the placebo group appear unlikely to be of biological significance. Seasonal and latitude variation in these IHD risk factors appear unrelated to corresponding variation in solar UVR exposure.
Subject(s)
Antithrombin III/metabolism , Fibrinogen/metabolism , Lipoproteins/blood , Myocardial Infarction/blood , Myocardial Infarction/radiotherapy , Plasminogen/metabolism , Ultraviolet Rays , Ultraviolet Therapy , Antithrombin III/radiation effects , Female , Fibrinogen/radiation effects , Humans , Lipoproteins/radiation effects , Male , Middle Aged , Plasminogen/radiation effects , Prothrombin Time , Thrombin Time , Whole-Body IrradiationABSTRACT
The effect of laser irradiation on the thrombogenicity of thrombus was evaluated by treating thrombi, formed in-vitro from canine blood, with two different doses of cw Nd:YAG laser energy at 1064 nm. The thrombi were then incubated with whole blood, and the plasma levels of fibrinogen and thrombin-antithrombin III-complexes were measured. A statistically significant decrease (p < 0.05) in the thrombogenicity was indicated by a reduction in both fibrinogen consumption and levels of thrombin-antithrombin III-complexes in the high dose group (600 joules, 100 degrees C peak temperature) in comparison to the low dose group (300 joules, 70 degrees C peak temperature) and the untreated thrombi. These findings suggest that laser irradiation of thrombus at an appropriate dose may substantially reduce its thrombogenicity and ability to modulate hemostasis.
