ABSTRACT
Human brucellosis is a disease of protean manifestations, and has been implicated in complications and focal disease in many human organ systems. However, little is collectively known about the background, the course, the clinical characteristics, the diagnostic issues raised, and the short- and long-term therapeutic approaches in patients with aortic involvement as a complication of brucellosis. With the aim to glean from the literature useful information to better understand and manage this complication, a computerized search without language restriction was conducted using PubMed and SCOPUS. An article was considered eligible for inclusion in the systematic review if it reported data on patients with involvement of the aorta due to a Brucella infection. The epidemiologic and clinical characteristics of 44 cases of brucellar aortic involvement found through the systematic review of the literature were analyzed together with those of two new cases that we treated in the recent past. This complication involved the ascending thoracic aorta in 18 cases (in 16 of them as a consequence of brucellar endocarditis), and the descending thoracic aorta or the abdominal aorta in the remaining 30 cases. In the latter it was associated with spondylodiscitis of the lumbar spine in 13 cases. History of or symptoms indicative of brucellosis were not universally present. Brucellar aortic involvement represents a possibly underdiagnosed and underreported complication with major morbidity and mortality potential. Experience with novel invasive therapeutic approaches remains limited. Early suspicion through detailed history and diagnosis, aided by advances in aortic imaging, would allow for better planning of therapeutic interventions.
Subject(s)
Aorta/parasitology , Aortic Aneurysm/parasitology , Aortic Rupture/parasitology , Brucellosis/complications , Aorta/pathology , Aortic Aneurysm/diagnosis , Aortic Aneurysm/therapy , Aortic Rupture/diagnosis , Aortic Rupture/therapy , Brucella/isolation & purification , Brucellosis/diagnosis , Brucellosis/epidemiology , Diagnosis, Differential , Discitis/complications , Humans , Risk FactorsABSTRACT
This note describes the sudden death of a dog by the rupture of the thoracic aorta caused by the presence of Angiostrongylus vasorum. A female mongrel canine with a history of weight loss and exhaustion died two hours after clinical examination. At necropsy, performed one hour after death, showed the presence of clotted blood in the thoracic cavity. Haemothorax was diagnosed. The thoracic aorta wall was thin, congested and an abnormal hole in the wall was detected approximately 0.5 cm from the entrance to the diaphragm. From clotted blood collected from the thoracic cavity, 224 first stage larvae (L1) and 15 adults of Angiostrongylus vasorum were recovered alive. Also, from a blood clot found in the aorta, four adult females and 47 L1 larvae were recovered alive. Possibly, this parasite was responsible for the aortic rupture and death of the animal.
Subject(s)
Aorta, Thoracic/parasitology , Aortic Rupture/veterinary , Death, Sudden/veterinary , Dog Diseases/parasitology , Strongylida Infections/veterinary , Angiostrongylus/classification , Angiostrongylus/isolation & purification , Animals , Aorta, Thoracic/pathology , Aortic Rupture/parasitology , Autopsy/veterinary , Death, Sudden/etiology , Diagnosis, Differential , Dog Diseases/diagnosis , Dog Diseases/pathology , Dogs , Fatal Outcome , Feces/parasitology , Female , Larva , Male , Strongylida Infections/complications , Strongylida Infections/diagnosisABSTRACT
This report details the post-mortem discovery of a larva of Spirocerca lupi in the caudal thoracic aorta of a 2-year, male bush dog (Speothos venaticus). This individual presented no clinical symptoms of the parasite's presence prior to its sudden death. The cause of death was determined to be acute bleeding following the rupture of an aneurysm in the caudal thoracic aorta as a result of the parasite located there. This is the first report of S. lupi in a bush dog.
