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1.
JAMA Ophthalmol ; 139(2): 165-173, 2021 02 01.
Article in English | MEDLINE | ID: mdl-33331850

ABSTRACT

Importance: Glaucoma-related adverse events constitute serious complications of cataract removal in infancy, yet long-term data on incidence and visual outcome remain lacking. Objective: To identify and characterize incident cases of glaucoma and glaucoma-related adverse events (glaucoma + glaucoma suspect) among children in the Infant Aphakia Treatment Study (IATS) by the age of 10.5 years and to determine whether these diagnoses are associated with optic nerve head (ONH) and peripapillary retinal nerve fiber layer (RNFL) assessment. Design, Setting, and Participants: Analysis of a multicenter randomized clinical trial of 114 infants with unilateral congenital cataract who were aged 1 to 6 months at surgery. Data on long-term glaucoma-related status and outcomes were collected when children were 10.5 years old (July 14, 2015, to July 12, 2019) and analyzed from March 30, 2019, to August 6, 2019. Interventions: Participants were randomized at cataract surgery to either primary intraocular lens (IOL), or aphakia (contact lens [CL]). Standardized definitions of glaucoma and glaucoma suspect were created for IATS and applied for surveillance and diagnosis. Main Outcomes and Measures: Development of glaucoma and glaucoma + glaucoma suspect in operated-on eyes up to age 10.5 years, plus intraocular pressure, axial length, RNFL (by optical coherence tomography), and ONH photographs. Results: In Kaplan-Meier analysis, for all study eyes combined (n = 114), risk of glaucoma after cataract removal rose from 9% (95% CI, 5%-16%) at 1 year, to 17% (95% CI, 11%-25%) at 5 years, to 22% (95% CI, 16%-31%) at 10 years. The risk of glaucoma plus glaucoma suspect diagnosis after cataract removal rose from 12% (95% CI, 7%-20%) at 1 year, to 31% (95% CI, 24%-41%) at 5 years, to 40% (95% CI, 32%-50%) at 10 years. Risk of glaucoma and glaucoma plus glaucoma suspect diagnosis at 10 years was not significantly different between treatment groups. Eyes with glaucoma (compared with eyes with glaucoma suspect or neither) had longer axial length but relatively preserved RNFL and similar ONH appearance and visual acuity at age 10 years. Conclusions and Relevance: Risk of glaucoma-related adverse events continues to increase with longer follow-up of children following unilateral cataract removal in infancy and is not associated with primary IOL implantation. Development of glaucoma (or glaucoma suspect) after removal of unilateral congenital cataract was not associated with worse visual acuity outcomes at 10 years. Trial Registration: ClinicalTrials.gov Identifier: NCT00212134.


Subject(s)
Aphakia, Postcataract/surgery , Cataract Extraction/adverse effects , Cataract/therapy , Eye Diseases, Hereditary/surgery , Glaucoma/epidemiology , Lens Implantation, Intraocular/adverse effects , Lenses, Intraocular/adverse effects , Aphakia, Postcataract/diagnosis , Aphakia, Postcataract/epidemiology , Cataract/congenital , Cataract/diagnosis , Cataract/epidemiology , Child , Eye Diseases, Hereditary/diagnosis , Eye Diseases, Hereditary/epidemiology , Female , Glaucoma/diagnostic imaging , Glaucoma/physiopathology , Humans , Incidence , Infant , Intraocular Pressure , Male , Prospective Studies , Risk Assessment , Risk Factors , Time Factors , Treatment Outcome , Visual Acuity
2.
Retina ; 41(5): 940-946, 2021 May 01.
Article in English | MEDLINE | ID: mdl-33009221

ABSTRACT

PURPOSE: To compare the visual outcomes and complication rates of sutureless cannula-based intraocular lens scleral (SCILS) fixation performed with 25-gauge (25 G) versus 27-gauge (27 G) instrumentation. METHODS: A retrospective chart review of consecutive cases of eyes without capsular support that underwent SCILS fixation of a three-piece intraocular lens. Sutureless cannula-based intraocular lens scleral fixation was performed by transconjunctival use of either 25-G or 27-G trocar cannulas. During postoperative follow-up evaluations, visual acuity and intraocular pressure were measured, and slit-lamp and indirect ophthalmoscopy examinations were performed to assess for development of known complications. RESULTS: A total of 69 eyes underwent 25 G (27 eyes) or 27 G (42 eyes) SCILS fixation. The mean preoperative logarithm of the minimum angle of resolution visual acuity trended toward improvement from 0.95 ± 0.68 (20/178 Snellen equivalent) to 0.67 ± 0.64 (20/94 Snellen equivalent) for 25 G group at 1 year. Similar trend toward visual acuity improvement was seen in 27 G group with a mean preoperative logarithm of the minimum angle of resolution visual acuity of 1.43 ± 0.94 (20/538 Snellen equivalent) improving to 0.86 ± 1.00 (20/145 Snellen equivalent) at 1 year. Statistically significant improvement was seen as early as postoperative week one for 27 G group (P < 0.01), whereas statistically significant worsening was noted at the same time in 25 G group (P = 0.01). There was a statistically significant reduction in intraocular lens displacement (P = 0.01) and need for reoperation (P = 0.01) in 27 G group. CONCLUSION: Compared with 25 G SCILS fixation, eyes managed with 27 G SCILS fixation experienced more rapid visual acuity improvement. In addition, there was a lower rate of complications including intraocular lens displacement and need for reoperation.


Subject(s)
Aphakia, Postcataract/surgery , Lens Implantation, Intraocular/methods , Postoperative Complications/epidemiology , Sclera/surgery , Sutureless Surgical Procedures/instrumentation , Visual Acuity/physiology , Aged , Aphakia, Postcataract/diagnosis , Aphakia, Postcataract/physiopathology , Cannula , Cataract Extraction/methods , Equipment Design , Female , Follow-Up Studies , Humans , Male , Middle Aged , Ophthalmoscopy , Retrospective Studies
3.
Cornea ; 39(11): 1359-1365, 2020 Nov.
Article in English | MEDLINE | ID: mdl-32833844

ABSTRACT

PURPOSE: To evaluate changes in central corneal thickness (CCT) and intraocular pressure (IOP) in children after surgery for congenital cataracts and to investigate the association between CCT and IOP. METHODS: For this prospective observational cohort study, we recruited patients undergoing surgery for unilateral or bilateral congenital cataracts. CCT and IOP were measured before surgery and 1, 3, 6, 12, and 24 months after surgery. RESULTS: Seventy-six children (152 eyes) were enrolled; 33 eyes were unaffected by cataracts, 77 were aphakic, and 42 were pseudophakic. In aphakic eyes, mean CCT increased by 31.14 ± 44.32 µm at 12 months postoperation and 33.09 ± 35.42 µm at 24 months postoperation; this increase was significantly higher than that in pseudophakic eyes 12 months after surgery (8.36 ± 19.91 µm; P < 0.001) and 24 months after surgery (0.31 ± 14.19 µm; P = 0.024). However, no significant differences in IOP were found between the different phakic states at 12 and 24 months postoperation (P = 0.672 and P = 0.080, respectively). There were also no significant differences in CCT and IOP before and after surgery in the unaffected eyes. CONCLUSIONS: Mean CCT peaked at 12 months, and the mean IOP remained normal in both the aphakic and pseudophakic eyes during this study. CCT and IOP were positively correlated, regardless of the phakic status or age, a relationship which suggests that both parameters should be monitored closely in postsurgical patients for up to 12 months and in this time, may impact the ability to diagnose glaucoma.


Subject(s)
Aphakia, Postcataract/diagnosis , Cataract Extraction , Cataract/congenital , Cornea/pathology , Corneal Pachymetry/methods , Intraocular Pressure/physiology , Aphakia, Postcataract/physiopathology , Child, Preschool , Female , Follow-Up Studies , Humans , Infant , Male , Postoperative Period , Prospective Studies
4.
Eur J Ophthalmol ; 30(6): 1370-1380, 2020 Nov.
Article in English | MEDLINE | ID: mdl-31313600

ABSTRACT

PURPOSE: To determine the incidence, timing and risk factors for glaucoma and visual axis opacification development following surgery for congenital cataract in the first year of life. METHODS: A prospective case series of all cataract surgery performed in Temple Street Children's University Hospital over a 28-year period was conducted. A total of 93 subjects (135 eyes) were analysed. Sixty-two eyes had a primary intraocular lens inserted at the time of surgery; 73 eyes were aphakic. We recorded patient demographics, age at surgery, length of follow-up, rates and time to diagnosis of glaucoma and rates of visual axis opacification. Relative risk analysis was performed to identify potential risk factors for secondary glaucoma and visual axis opacification. RESULTS: Mean length of follow-up was 160.02 ± 64.42 months (13.3 years), range 40-336 months. Final mean LogMAR across all groups was 0.85 ± 0.51 (0.90). Overall 45 (33.33%) eyes developed secondary glaucoma, 12 (19.4%) in pseudophakic eyes and 33 (45.21%) in aphakic eyes. The incidence of glaucoma was highest in bilateral aphakia (relative risk 1.96, p = 0.0240) and in eyes with corneal diameter <9.5 mm (relative risk 1.93, p = 0.0364). There was no significant difference in glaucoma rates between pseudophakia and aphakia in those operated on less than 2.5 months of age. Secondary glaucoma occurred between 3 months to 16.5 years post surgery. Rates of visual axis opacification were lower in aphakia compared to pseudophakia (relative risk 0.59, p = 0.0098). CONCLUSION: Overall glaucoma rates of one-third are similar to those recorded in the infantile aphakic treatment study. It can occur up to 17 years post cataract surgery, evidence that long-term follow-up is imperative.


Subject(s)
Aphakia, Postcataract/complications , Cataract Extraction/adverse effects , Forecasting , Glaucoma/etiology , Lens Implantation, Intraocular/adverse effects , Lenses, Intraocular/adverse effects , Pseudophakia/complications , Aphakia, Postcataract/diagnosis , Child , Child, Preschool , Cross-Sectional Studies , Disease Progression , Female , Follow-Up Studies , Glaucoma/diagnosis , Glaucoma/physiopathology , Humans , Male , Prospective Studies , Pseudophakia/physiopathology , Risk Factors
5.
J Fr Ophtalmol ; 42(8): 829-833, 2019 Oct.
Article in English | MEDLINE | ID: mdl-31200981

ABSTRACT

PURPOSE: To evaluate iris structure in aphakic eyes scheduled for placement of a secondary intraocular lens. METHODS: Twenty-eight aphakic eyes of 28 patients who were scheduled for secondary intraocular lens implantation between January 2012 and January 2017 at Beyoglu Eye Training and Research Hospital after a complicated cataract surgery were recruited in this study. The phakic fellow eyes of the patients were defined as a control group. Iris thickness was assessed using anterior segment optical coherence tomography at 750µm (IT750) and 2000µm (IT2000) from the scleral spur. Moreover, maximum iris thickness (ITM) and anterior chamber angle parameters such as trabecular iris surface area at 500 and 750µm (TISA500, TISA750), angle opening distances at 500 and 750µm (AOD500, AOD750) and anterior chamber depth (ACD) were also evaluated. RESULTS: Mean IT750, IT2000 and ITM readings and were significantly lower in the aphakic eyes compared to the healthy eyes (P=0.04, P=0.01, P=0.01 respectively). Anterior chamber parameters (TISA500, TISA750, AOD500 and AOD750) and ACD were significantly increased in aphakic eyes following complicated cataract surgery compared to healthy fellow eyes (all P<0.001). CONCLUSIONS: Complicated cataract surgery leading to aphakia results in decreased iris thickness and increased anterior chamber depth. These findings might be helpful in the selection of the type of surgery for placement of a secondary IOL.


Subject(s)
Anterior Chamber/diagnostic imaging , Aphakia, Postcataract/diagnosis , Cataract Extraction/adverse effects , Iris/diagnostic imaging , Iris/pathology , Postoperative Complications/diagnosis , Aged , Anterior Chamber/pathology , Anterior Eye Segment/diagnostic imaging , Anterior Eye Segment/pathology , Aphakia, Postcataract/complications , Aphakia, Postcataract/pathology , Case-Control Studies , Cataract/diagnosis , Cataract/pathology , Cross-Sectional Studies , Female , Gonioscopy/methods , Humans , Iris/ultrastructure , Male , Middle Aged , Postoperative Complications/pathology , Tomography, Optical Coherence/methods
6.
J Cataract Refract Surg ; 44(4): 479-486, 2018 Apr.
Article in English | MEDLINE | ID: mdl-29685773

ABSTRACT

PURPOSE: To compare the pseudophakodonesis of in-the-bag intraocular lens (IOL) and a secondary fixated IOL by tracking the Purkinje image IV. SETTING: Dr. Agarwal's Eye Hospital and Eye Research Centre, Chennai, India. DESIGN: Prospective case series. METHODS: The IOL movement was recorded via slitlamp videography (DC3), streamed in video editor (Pinnacle), and evaluated by ImageJ analysis. The positional difference of Purkinje IV in relation to the stationary image Purkinje I at 3 random timeframes was measured. Pseudophakodonesis was quantified, compared, and correlated clinically. RESULTS: The study comprised 127 eyes that had posterior chamber IOLs (PC IOLs) (n = 50), anterior chamber IOLs (AC IOLs) (n = 20), iris-claw IOLs (n = 20), glued IOLs (n = 30), and sutured scleral-fixated IOLs (n = 7). The iris-claw IOL showed significant difference in Purkinje IV at various timeframes (P = .0418) whereas others showed no significant change. On comparison of the Purkinje IV difference, there was a significant difference between the PC IOL and the iris-claw IOL (P = .0001), the glued IOL and the iris-claw IOL (P = .0020), and the AC IOL and the iris-claw IOL (P = .0302). The iris-claw IOL showed significant exaggeration of the position of Purkinje IV (P = .0395) after saccade. Pseudophakodonesis seemed mild (difference < 0.5 mm) in the PC IOL (68%), glued IOL (53.3%), and AC IOL (50%); moderate in the scleral-fixated IOL (71.4%); and severe (≥ 1.0 mm) in the iris-claw IOL (55%). CONCLUSION: Positional difference in Purkinje IV was highest in iris-claw IOLs and lowest in PC IOLs.


Subject(s)
Anterior Chamber/surgery , Aphakia, Postcataract/surgery , Iris/diagnostic imaging , Lenses, Intraocular , Suture Techniques , Video Recording/methods , Visual Acuity , Anterior Chamber/diagnostic imaging , Aphakia, Postcataract/diagnosis , Follow-Up Studies , Humans , Iris/surgery , Prospective Studies , Sclera/surgery
7.
Int Ophthalmol ; 38(3): 951-957, 2018 Jun.
Article in English | MEDLINE | ID: mdl-28444525

ABSTRACT

PURPOSE: To compare the biometric measurements obtained from the Verion Image-Guided System to those obtained by auto-refracto-keratometer in normal eyes. METHODS: This is a prospective, observational, comparative study conducted at the Asociación para Evitar la Ceguera en México I.A.P., Mexico. Three sets of keratometry measurements were obtained using the image-guided system to assess the coefficient of variation, the within-subject standard deviation and intraclass correlation coefficient (ICC). A paired Student t test was used to assess statistical significance between the Verion and the auto-refracto-keratometer. A Pearson's correlation coefficient (r) was obtained for all measurements, and the level of agreement was verified using Bland-Altman plots. RESULTS: The right eyes of 73 patients were evaluated by each platform. The Verion coefficient of variation was 0.3% for the flat and steep keratometry, with the ICC being greater than 0.9 for all parameters measured. Paired t test showed statistically significant differences between groups (P = 0.0001). A good correlation was evidenced for keratometry values between platforms (r = 0.903, P = 0.0001 for K1, and r = 0.890, P = 0.0001). Bland-Altman plots showed a wide data spread for all variables. CONCLUSION: The image-guided system provided highly repeatable corneal power and keratometry measurements. However, significant differences were evidenced between the two platforms, and although values were highly correlated, they showed a wide data spread for all analysed variables; therefore, their interchangeable use for biometry assessment is not advisable.


Subject(s)
Aphakia, Postcataract/diagnosis , Biometry/methods , Cataract Extraction , Cornea/pathology , Corneal Topography/methods , Lenses, Intraocular , Adolescent , Adult , Aphakia, Postcataract/physiopathology , Female , Humans , Male , Middle Aged , Prospective Studies , Prosthesis Design , Reproducibility of Results , Young Adult
8.
Ophthalmology ; 124(5): 730-733, 2017 05.
Article in English | MEDLINE | ID: mdl-28196730

ABSTRACT

PURPOSE: To report the longitudinal change in axial length (AL) from the time of unilateral cataract surgery at age 1 to 7 months to age 5 years, and to compare AL growth of operated eyes with that of fellow unoperated eyes. DESIGN: Comparative case series. PARTICIPANTS: Infants enrolled in the Infant Aphakia Treatment Study (IATS). METHODS: The AL at baseline and age 5 years and change in AL were analyzed relative to treated versus fellow eye, visual outcome, and treatment modality (contact lens [CL] vs. intraocular lens [IOL]). Eyes with glaucoma or glaucoma suspect were excluded from primary analysis but reported separately. MAIN OUTCOME MEASURES: The AL growth from preoperative to age 5 years. RESULTS: Seventy patients were eligible; however, AL data for both eyes were available for 64 patients at baseline and 69 patients at age 5 years. The AL was significantly different between treated and fellow eyes preoperatively (18.1 vs. 18.7 mm, P < 0.0001) and at the final follow-up (21.4 vs. 22.1 mm, P = 0.0004). The difference in AL growth between treated and fellow eyes was not significant (3.3 vs. 3.5 mm, P = 0.31). The change in AL in eyes was similar with both treatments (CL 3.2 mm and IOL 3.4 mm, P = 0.53) and did not correlate with visual outcomes (P = 0.85). Eyes receiving additional surgery to clear the visual axis opacification grew significantly more compared with eyes not receiving surgery to clear the visual axis (3.8 vs. 2.7 mm, P = 0.013). Patients with glaucoma showed significantly more eye growth (5.7 mm) than those without glaucoma (3.3 mm) and glaucoma suspects (4.3 mm). CONCLUSIONS: Eyes treated for monocular cataract in infancy have axial growth similar to that of fellow eyes, despite having a shorter AL at the time of surgery. The change in AL in eyes was similar with both treatments (CL and IOL), did not correlate with visual outcomes, and was higher in eyes receiving additional surgery to clear the visual axis or eyes diagnosed with glaucoma.


Subject(s)
Aphakia, Postcataract/diagnosis , Axial Length, Eye/growth & development , Contact Lenses , Lens Implantation, Intraocular/methods , Visual Acuity , Aphakia, Postcataract/therapy , Child, Preschool , Female , Follow-Up Studies , Humans , Infant , Infant, Newborn , Male , Time Factors
9.
J Pediatr Ophthalmol Strabismus ; 53(6): 339-343, 2016 Nov 01.
Article in English | MEDLINE | ID: mdl-27668871

ABSTRACT

PURPOSE: To review the impact of vitrectomy and tube shunts on mean intraocular pressure (IOP) and number of glaucoma medications in pediatric aphakic glaucoma. METHODS: A retrospective review of pediatric patients who underwent combined vitrectomy and glaucoma tube shunt surgery for aphakic glaucoma was conducted. Inclusion criteria were: age 18 years or younger, diagnosis of aphakic glaucoma, preoperative IOP data, and postoperative IOP data for at least 6 months. Mean IOP lowering at 1 year, number of glaucoma medications at 1 year, and surgical complications, including tube occlusion in the postoperative period, were noted. RESULTS: The mean ± standard deviation preoperative IOP was 33.9 ± 10.6 mm Hg (range: 18 to 57 mm Hg) with a mean of three topical IOP-lowering medications. A total of 5 (36%) Ahmed and 9 (64%) Baerveldt tube shunts were placed. One of the Baerveldt tube shunt procedures was combined with revision of a traumatically dislocated tube. The mean IOP at 12 months postoperatively was 16.6 ± 5.8 mm Hg (range: 6 to 28 mm Hg; P < .01, t = 3.74, df = 13) with a mean of 2.3 glaucoma medications. There were no cases of tube occlusion, corneal decompensation, endophthalmitis, or retinal detachment over the 12 months of follow-up. CONCLUSIONS: Combined vitrectomy and placement of a glaucoma tube shunt can be safe and effective in lowering IOP based on mean IOP values and number of glaucoma medications at 1 year. [J Pediatr Ophthalmol Strabismus. 2016;53(6):339-343.].


Subject(s)
Aphakia, Postcataract/surgery , Glaucoma Drainage Implants , Glaucoma/surgery , Vitrectomy , Adolescent , Aphakia, Postcataract/diagnosis , Aphakia, Postcataract/physiopathology , Cataract/congenital , Cataract Extraction , Child , Child, Preschool , Female , Glaucoma/diagnosis , Glaucoma/physiopathology , Humans , Infant , Intraocular Pressure/physiology , Male , Retrospective Studies , Visual Acuity/physiology
10.
JAMA Ophthalmol ; 134(8): 863-9, 2016 Aug 01.
Article in English | MEDLINE | ID: mdl-27228110

ABSTRACT

IMPORTANCE: Patching has been a mainstay in treating unilateral congenital cataract. However, its efficacy has not been rigorously assessed. OBJECTIVE: To examine the association between patching and visual acuity in a cohort of children treated for unilateral congenital cataract. DESIGN, SETTING, AND PARTICIPANTS: This study was a secondary analysis of a randomized clinical trial (Infant Aphakia Treatment Study) of infants born from August 1, 2004, through December 31, 2008, who were treated with 1 of 2 treatments for unilateral congenital cataract and followed up to 5 years of age. Data analysis was performed from March 1, 2013, to March 1, 2016. INTERVENTIONS: Cataract extraction and randomization to receipt of an intraocular lens vs being left aphakic for the first 5 years of life. MAIN OUTCOMES AND MEASURES: Caregivers reported patching in the previous 48 hours in quarterly semistructured telephone interviews. The mean number of hours of patching per day was calculated from surgery to the first birthday (n = 92) and between 12 and 48 months of age (n = 102). Monocular optotype acuity was assessed at 4½ years of age by a traveling examiner using the Aphakia Treatment Study HOTV protocol. RESULTS: The Infant Aphakia Treatment Study enrolled 114 children; 57 were randomized to each treatment group. At 4½ years of age, optotype visual acuity was assessed in 112 children. The current analyses exclude an additional 3 children (2 who had adverse events that limited visual potential and 1 who had Stickler syndrome), leaving 109 total children analyzed (59 female [54.1%] and 92 white [84.4%]). Caregivers reported patching their children a mean (SD) of 3.73 (1.47) hours per day in the first year of life and 3.43 (2.04) hours per day thereafter. An association between reported patching and treatment was not identified (mean difference in first year, -0.29 hours per day; 95% CI, -0.90 to 0.33 hours per day; mean difference between 12 and 48 months of age, -0.40 hours per day; 95% CI, -1.20 to 0.40 hours per day). Visual acuity was associated with reported hours of patching in the first year of life (r = -0.32; 95% CI, -0.49 to -0.13) and between 12 and 48 months of age (r = -0.36; 95% CI, -0.52 to -0.18). However, patching accounted for less than 15% of the variance in logMAR acuity at 4½ years of age. CONCLUSIONS AND RELEVANCE: These results support the association of occlusion throughout the preschool years with improved visual acuity in infants treated for unilateral congenital cataract. However, similar visual outcomes were achieved with varying amounts of patching. These conclusions should be interpreted in the context of limitations related to generalizability from incomplete data collected in a clinical trial. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00212134.


Subject(s)
Aphakia, Postcataract/therapy , Cataract Extraction , Cataract/congenital , Contact Lenses , Visual Acuity/physiology , Aphakia, Postcataract/diagnosis , Aphakia, Postcataract/physiopathology , Child, Preschool , Female , Follow-Up Studies , Humans , Infant , Male , Retrospective Studies , Sensory Deprivation , Time Factors
11.
Vestn Oftalmol ; 130(4): 57-61, 2014.
Article in Russian | MEDLINE | ID: mdl-25306725

ABSTRACT

UNLABELLED: The purpose of the study was to develop differentiated approach for secondary intraocular lens (IOL) implantation in children after congenital cataract extraction in infancy. MATERIAL AND METHODS: Secondary IOL implantation was performed in 42 children (56 eyes) aged from 1.5 to 6 years who underwent congenital cataract surgery at the age of 2-10 months. A total of 19 children had unilateral involvement. In 14 cases of bilateral aphakia the implantation was performed on both eyes. In 9 children a single-step cataract extraction with unilateral IOL implantation was followed by a delayed IOL implantation on the previously operated contralateral eye. The posterior lens capsule was intact in 39 eyes, while in 17 it had various congenital defects. Capsule opacification was found in 34 eyes, either congenital (8 eyes) or acquired (26 eyes). Along with conventional ophthalmic assessment, other examinations that are essential for IOL power calculation (autorefractomentry and ultrasound biomicroscopy - UBM) and posterior chamber assessment (UBM) were performed. The injection of either monoblock (Acrysof SN60 WF; SN60AT, (Alcon)) or tripartite (Acrysof MA60AC (Alcon)) intraocular lens was done through a tunnel corneal incision. Monitoring period varied from 6 months to 4 years. RESULTS: The choice of surgical tactics, IOL model and fixation method depended on the integrity of the capsular bag, condition of the posterior capsule, and presence of iridocapsular adhesions. Intracapsular IOL implantation was performed in 28.2% of eyes with intact posterior capsule and in 11.8% of eyes with the capsule defects. In three eyes with no capsular support IOLs were sutured to the sclera. In most children (76.8%) posterior chamber reconstruction had to be performed due to iridocapsular adhesions. CONCLUSION: The choice of surgical tactics and the extent of surgical intervention for the purpose of secondary IOL implantation in children who underwent congenital cataract extraction are individual and depend on the integrity of the capsular bag.


Subject(s)
Aphakia, Postcataract , Capsule Opacification , Cataract Extraction/adverse effects , Cataract , Lens Implantation, Intraocular , Aphakia, Postcataract/diagnosis , Aphakia, Postcataract/surgery , Capsule Opacification/diagnosis , Capsule Opacification/etiology , Capsule Opacification/surgery , Cataract/congenital , Cataract/diagnosis , Cataract Extraction/methods , Child , Child, Preschool , Diagnostic Techniques, Ophthalmological , Female , Humans , Infant , Lens Implantation, Intraocular/adverse effects , Lens Implantation, Intraocular/methods , Lenses, Intraocular , Male , Reoperation , Treatment Outcome , Visual Acuity
12.
Indian J Ophthalmol ; 62(6): 692-4, 2014 Jun.
Article in English | MEDLINE | ID: mdl-25005197

ABSTRACT

AIM: To evaluate and compare the predictive capacity of four intraocular lens (IOL) power calculation formulas (SRK/T, Hoffer Q, Holladay 1, and Haigis) in eyes shorter than 22.0 mm. SETTING AND DESIGN: Observational study. MATERIALS AND METHODS: Participants in our study were 69 consecutive patients with a preoperative axial length (AL) of less than 22.0 mm in one or both eyes. All patients underwent phacoemulsification with IOL implantation and postoperative target of refraction was analyzed. Specifically, the differences in the mean absolute estimation error (AE) for the four formulas were analyzed. Furthermore, the percentage of eyes with AE within ± 0.5 and ± 1.0 D for each formula was estimated, as well as the correlation coefficient (r) between the AL and estimation error (E) for each formula. The Mann-Whitney U test was used to compare differences in the AEs of the formulas. A statistically significant difference was defined as P < 0.05. RESULTS: The Haigis formula had statistically significant smaller mean AE in comparison to Holladay 1, Hoffer Q, and SRK/T. The Haigis formula predicted more eyes with E within ± 0.5 and ± 1.0 D of predicted spherical equivalent compared to other formulas. Correlation between AL and AE revealed a negative r value and P < 0.05 for all formulas. CONCLUSIONS: Haigis formula provides more accurate results concerning the postoperative target of refraction in eyes with AL less than 22.0 mm. Hoffer Q could be also used as an alternative.


Subject(s)
Algorithms , Aphakia, Postcataract/surgery , Axial Length, Eye , Cataract/diagnosis , Lenses, Intraocular , Phacoemulsification/methods , Refraction, Ocular/physiology , Aged , Aphakia, Postcataract/diagnosis , Aphakia, Postcataract/physiopathology , Female , Follow-Up Studies , Humans , Male , Postoperative Period , Prosthesis Design , Retrospective Studies , Visual Acuity
13.
Klin Monbl Augenheilkd ; 231(8): 784-7, 2014 Aug.
Article in German | MEDLINE | ID: mdl-24992236

ABSTRACT

BACKGROUND: The aim of this study was to evaluate the indication, visual and refractive outcome, endothelial cell loss and complication rate after implantation of a posterior iris-claw aphakic intraocular lens (IOL). PATIENTS AND METHODS: This retrospective study comprised 62 eyes of 56 patients without adequate capsular support undergoing posterior iris-claw aphakic IOL implantation (Verisyse™/Artisan®) between 2006 and 2012. Mean follow-up was 34 months (range from 13 to 78 months). RESULTS: The IOLs were inserted during primary lens surgery in 11 phakic eyes (17.8 %), during an IOL exchange procedure for dislocated posterior chamber IOLs in 34 eyes (54.8 %), and as a secondary procedure in 17 aphakic eyes (27.4 %). The final best spectacle-corrected visual acuity (BSCVA) in logMAR (mean 0.24 ± 0.45) improved significantly (p < 0.001) compared to the preoperative BSCVA (mean 0.61 ± 0.65). The mean spherical equivalent improved from preoperative 7,25 ± 5,04 diopters (D) (range - 10.25 to + 16.0 D) to - 0.21 ± 1.01 D (range - 4.0 to 3.0 D) postoperatively. Mean central endothelial cell density was 1844 ± 690 cells/mm(2) preoperatively. After surgery mean endothelial cell density decreased statistically not significant with a loss of 5.5 % to 1743 ± 721 cells/mm(2) (p > 0.05) at last follow-up visit. Complications included cystoid macular oedema in 4 eyes (6.4 %), early postoperative hypotony in 2 eyes (3.2 %), pupil ovalisation in 2 eyes (3.2 %), traumatic iris-claw IOL disenclavation in 2 eyes (3.2 %) and spontaneous IOL disenclavation in one eye (1.6 %). CONCLUSIONS: Retropupillar iris-claw IOL provides good visual and refractive outcomes with a low endothelial cell loss and can be used for a wide range of indications in eyes without adequate capsular support.


Subject(s)
Corneal Endothelial Cell Loss/etiology , Lens Implantation, Intraocular/adverse effects , Lenses, Intraocular/adverse effects , Postoperative Complications/etiology , Adolescent , Adult , Aged , Aged, 80 and over , Aphakia, Postcataract/diagnosis , Aphakia, Postcataract/etiology , Aphakia, Postcataract/surgery , Cell Count , Corneal Endothelial Cell Loss/diagnosis , Endothelium, Corneal/pathology , Female , Humans , Male , Middle Aged , Postoperative Complications/diagnosis , Prosthesis Design , Refraction, Ocular , Retrospective Studies , Visual Acuity , Young Adult
14.
J Glaucoma ; 23(7): 449-54, 2014 Sep.
Article in English | MEDLINE | ID: mdl-23661045

ABSTRACT

BACKGROUND: Aphakic and juvenile open-angle glaucoma (JOAG) cases often prove to be challenging to manage, frequently requiring surgical intervention. Angle surgery has some reported success in these cases. PURPOSE: The purpose of this study was to evaluate 360-degree trabeculotomy, facilitated by iTrack, for refractory aphakic glaucoma and JOAG. PATIENTS AND METHODS: This study was conducted to evaluate the success and complication rates of illuminated microcatheter-assisted 360-degree trabeculotomy for aphakic glaucoma and JOAG (2 surgeons/2 sites, 2008 to 2011). The success of this surgery was defined as intraocular pressure ≤22 mm Hg with >30% reduction, without disease progression, oral glaucoma medications, or additional glaucoma surgery. One eye per subject was analyzed. All had gonioscopically open angles preoperatively. RESULTS: A total of 23 eyes status post iTrack-facilitated 360-degree trabeculotomy, 13 aphakic glaucoma cases (mean age 3.1 y at surgery), and 10 JOAG cases (mean age, 18.6 y) were included in the study. Complete cannulation/opening of the Schlemm canal occurred intraoperatively in 8 aphakic and in all JOAG cases. Success rates achieved at last follow-up were as follows: 8/13 (62%) aphakic glaucoma cases and 9/10 (90%) JOAG cases. Preoperative versus final intraocular pressure decreased for all surgically successful eyes (35.5±3.9 vs. 17.3±4.6 mm Hg for aphakic glaucoma, P<0.0001, after mean 30 mo and 30.7±7.4 vs. 13.4±2.8 mm Hg for JOAG, P=0.0001, after mean 10 mo). All trabeculotomy failures (n=5) occurred within 5 months. Complications included vitreous hemorrhage (2 aphakic eyes) and transient choroidal effusion (1 aphakic eye). CONCLUSIONS: iTrack-facilitated 360-degree trabeculotomy shows early promise for initial surgical treatment of medically refractory aphakic glaucoma and JOAG, with few complications and without affecting future surgical options.


Subject(s)
Aphakia, Postcataract/surgery , Catheters , Glaucoma, Open-Angle/surgery , Trabeculectomy/instrumentation , Adolescent , Adult , Aphakia, Postcataract/diagnosis , Aphakia, Postcataract/physiopathology , Child , Child, Preschool , Female , Follow-Up Studies , Glaucoma, Open-Angle/diagnosis , Glaucoma, Open-Angle/physiopathology , Gonioscopy , Humans , Infant , Intraocular Pressure/physiology , Lighting , Male , Retrospective Studies , Tonometry, Ocular , Trabeculectomy/methods , Treatment Outcome , Young Adult
15.
Vestn Oftalmol ; 130(6): 80-8, 2014.
Article in Russian | MEDLINE | ID: mdl-25715557

ABSTRACT

The paper provides current knowledge on cataract epidemiology worldwide and in the Russian Federation, including issues of cataractogenesis and prevention. An overview of medical equipment for preoperative and intraoperative diagnostics is provided. Key aspects of the conventional ultrasonic phacoemulsification method as well as the most marked trends in correction of aphakia with intraocular lenses and in design of the latter are presented. Major laser-assisted techniques, including those that imply the use of femtosecond laser systems, and results that they yielded to date are discussed in detail.


Subject(s)
Cataract , Diagnostic Techniques, Ophthalmological , Monitoring, Intraoperative/instrumentation , Phacoemulsification , Postoperative Complications/prevention & control , Aphakia, Postcataract/diagnosis , Cataract/diagnosis , Cataract/epidemiology , Cataract/physiopathology , Cataract/therapy , Diagnostic Techniques, Ophthalmological/instrumentation , Diagnostic Techniques, Ophthalmological/trends , Disease Progression , Humans , Monitoring, Intraoperative/methods , Outcome Assessment, Health Care , Phacoemulsification/instrumentation , Phacoemulsification/methods , Postoperative Complications/etiology , Secondary Prevention/methods
16.
Invest Ophthalmol Vis Sci ; 53(12): 7539-45, 2012 Nov 07.
Article in English | MEDLINE | ID: mdl-23074203

ABSTRACT

PURPOSE: To compare ocular axial elongation in infants after unilateral cataract surgery corrected with a contact lens (CL) or primary intraocular lens (IOL) implantation. METHODS: Baseline axial length (AL) was measured at the time of cataract surgery (1-6 months) and at age 1 year. AL at baseline and age 1 year and the change in length/mo were analyzed in relation to treatment modality, cataractous versus fellow eye, and age at surgery using linear mixed models. RESULTS: Mean baseline AL did not differ between the CL and IOL groups for either cataractous or fellow eyes. Eyes with cataracts were shorter than fellow eyes by an average of 0.6 mm (95% confidence interval [CI], 0.4-0.8 mm; P < 0.0001). For the operated eyes, the mean change in AL/mo was smaller in the CL group (0.17 mm/mo) than in the IOL group (0.24 mm/mo) (P = 0.0006) and was independent of age at surgery (P = 0.19). In contrast, the change in AL/mo for fellow eyes decreased with older age at surgery (P < 0.0001). At age 1 year, operated eyes treated with a CL were 0.6 mm shorter on average than operated eyes treated with an IOL (P = 0.009). CONCLUSIONS: At baseline, eyes with cataracts were shorter than fellow eyes. The change in AL/mo was smaller in operated eyes treated with a CL than in operated eyes treated with an IOL, but was not significantly related to age at surgery. (ClinicalTrials.gov number, NCT00212134.).


Subject(s)
Aphakia, Postcataract/rehabilitation , Cataract Extraction , Cataract/congenital , Contact Lenses , Lenses, Intraocular , Refractive Errors/rehabilitation , Aphakia, Postcataract/complications , Aphakia, Postcataract/diagnosis , Female , Follow-Up Studies , Humans , Infant , Infant, Newborn , Male , Postoperative Period , Refractive Errors/diagnosis , Refractive Errors/etiology , Treatment Outcome , Visual Acuity
19.
Ophthalmology ; 118(1): 17-23, 2011 Jan.
Article in English | MEDLINE | ID: mdl-20709402

ABSTRACT

PURPOSE: To report visual impairment and blindness and delay in presentation for surgery in Chinese pediatric patients with cataract. DESIGN: Retrospective case series. PARTICIPANTS: A total of 196 children (309 eyes) with congenital or developmental cataract. METHODS: Surgery was performed in all patients. Visual impairment and blindness were defined as best-corrected visual acuity < 20/60. The characteristics, visual acuity, and time delay to surgery of these children were evaluated. MAIN OUTCOME MEASURES: Incidence of visual impairment and blindness, ages at disease recognition and at surgery, and duration of delay in presentation for surgery. RESULTS: Visual acuity was 20/25 or better in 22 eyes (7.1%), between 20/25 and 20/40 in 72 eyes (23.3%), and between 20/40 and 20/60 in 87 eyes (28.2%). Visual impairment and blindness occurred in 41.4% of eyes, 52.0% of patients, 35.4% of patients with bilateral cataract, and 74.7% of patients with unilateral cataract. The frequency of visual impairment and blindness in eyes with combined nystagmus, combined strabismus, total cataract, nuclear cataract, and posterior polar cataract was 84.4%, 75%, 63.8%, 48%, and 48.3%, respectively. Severe postoperative complications resulted in 14.8% of visual impairment and blindness. The mean ages at disease recognition and at surgery were 22.6 ± 30.4 months and 68.3 ± 40.0 months, respectively. The mean delay of presentation for surgery was 49.6 ± 39.8 months in all patients and 35.7 ± 32.2 months in the patients with congenital cataract. The disease was recognized within 6 months of age in 46 children (40.7%) with bilateral cataract and 10 children (12.0%) with unilateral cataract. Among these children, only 18 (15.9%) with bilateral cataract and 1 (1.2%) with unilateral cataract underwent surgery between 3 and 6 months of age. No patients received surgical intervention within 3 months. CONCLUSIONS: Severe visual impairment is common in pediatric patients with cataract in China. Delayed presentation to the hospital and late surgical treatment are the major reasons and deserve greater attention.


Subject(s)
Blindness/diagnosis , Cataract Extraction , Cataract/diagnosis , Patient Acceptance of Health Care , Visual Acuity/physiology , Visually Impaired Persons , Age Factors , Aphakia, Postcataract/diagnosis , Aphakia, Postcataract/physiopathology , Asian People/ethnology , Blindness/ethnology , Blindness/physiopathology , Cataract/ethnology , Cataract/physiopathology , Child , Child, Preschool , China/epidemiology , Female , Follow-Up Studies , Humans , Infant , Male , Nystagmus, Pathologic/diagnosis , Nystagmus, Pathologic/ethnology , Nystagmus, Pathologic/physiopathology , Pseudophakia/diagnosis , Pseudophakia/physiopathology , Retinoscopy , Retrospective Studies , Strabismus/diagnosis , Strabismus/ethnology , Strabismus/physiopathology , Time Factors
20.
J AAPOS ; 14(6): 522-6, 2010 Dec.
Article in English | MEDLINE | ID: mdl-21168075

ABSTRACT

PURPOSE: To characterize the longitudinal changes of refraction in aphakic eyes after early surgery for congenital cataract and to evaluate longitudinally measured aphakic refraction (individual vs group mean) as a noninvasive indicator of postoperative disturbances in ocular development. METHODS: Records of children who had cataract surgery during their first year of life between 1980 and 1995 were obtained from a prospective, population-based study of congenital cataract. Only children with regular follow-up were included. Postoperative aphakic refraction was calculated at the corneal plane. Data were obtained up to 36 months of age. RESULTS: The study included 28 children (49 eyes) who underwent surgery at a median age of 2.8 months (range, 0-9 months). The decrease of aphakic refraction at the corneal plane followed a logarithmic trend (R(2) = 0.95). A total of 36 eyes followed this pattern, with no growth in 8 eyes and an increased growth rate in 1 eye with uncontrolled glaucoma and 4 eyes of 2 children with Down syndrome. CONCLUSIONS: Most aphakic eyes follow a predictable, logarithmic change in refraction in the first 3 years of life, Longitudinal monitoring of refraction may prove to be a useful, noninvasive screening method for early detection of disturbances in aphakic eye growth.


Subject(s)
Aphakia, Postcataract/physiopathology , Cataract Extraction/adverse effects , Cataract/congenital , Eye/growth & development , Refraction, Ocular/physiology , Aphakia, Postcataract/diagnosis , Child, Preschool , Follow-Up Studies , Humans , Infant , Infant, Newborn , Logistic Models , Longitudinal Studies , Retrospective Studies , Vision Screening/methods , Vision, Monocular
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