ABSTRACT
Simian hemorrhagic fever (SHF) is lethal for macaques. Based on clinical presentation and serological diagnosis, all reported SHF outbreaks were thought to be caused by different strains of the same virus, simian hemorrhagic fever virus (SHFV; Arteriviridae). Here we show that the SHF outbreaks in Sukhumi in 1964 and in Alamogordo in 1989 were caused not by SHFV but by two novel divergent arteriviruses. Our results indicate that multiple divergent simian arteriviruses can cause SHF.
Subject(s)
Arterivirus Infections/veterinary , Arterivirus/isolation & purification , Hemorrhagic Fevers, Viral/veterinary , Macaca/virology , Primate Diseases/virology , Amino Acid Sequence , Animals , Arterivirus/classification , Arterivirus/genetics , Arterivirus/physiology , Arterivirus Infections/history , Arterivirus Infections/virology , Evolution, Molecular , Hemorrhagic Fevers, Viral/history , Hemorrhagic Fevers, Viral/virology , History, 20th Century , Humans , Molecular Sequence Data , Phylogeny , Primate Diseases/history , Sequence Homology, Amino Acid , Viral Proteins/chemistry , Viral Proteins/geneticsABSTRACT
The results of the study of SHF and virus SHF for the last period since their discovery are summed up. It was established that the source of this infection fatal for Asian macaques are African monkeys--virus carriers. There is still a danger of the occurrence of epizootics in Primatological Centers at the importation of these monkeys for research. The importance of the obtained experimental SHF in macaques was emphasized. This model is unique, safe and adequate. It is necessary for further study of pathogenesis and evaluation of the means of pathogenetic therapy of HF dangerous to human health.
