ABSTRACT
OBJECTIVE: Migraine is still an unsolved problem. This clinical trial investigates the efficacy and tolerance of Petasites hybridus in the prophylaxis of migraine. METHODS: A randomized, group-parallel, placebo-controlled, double-blind clinical study was carried out with a special CO2 extract from the rhizome of Petasites hybridus. Following a four-week run-in phase, 60 patients received either the special Petasites hybridus extract Petadolex or placebo at a dosage of two capsules (each capsule contains 25 mg) twice daily over 12 weeks. Outcome variables included the frequency, intensity and duration of migraine attacks as well as any accompanying symptoms. RESULTS: The frequency of migraine attacks decreased by a maximum of 60 percent compared to the baseline. This reduction in migraine attacks with Petadolex was significant (p < 0.05) compared to placebo. No adverse events were reported. Petasites was exceptionally well tolerated. CONCLUSIONS: The results suggest that migraine patients can benefit from prophylactic treatment with this special extract. The combination of high efficacy and excellent tolerance emphasizes the particular value that Petasites hybridus has for the prophylactic treatment of migraine.
Subject(s)
Asteraceae/therapeutic use , Migraine Disorders/prevention & control , Phytotherapy , Plant Extracts/therapeutic use , Double-Blind Method , Female , Humans , MaleABSTRACT
Three flavones, 5,7-dihydroxy-2',3',4',5'-tetramethoxyflavone, 5,4'-dihydroxy-7,2',3',5'-tetramethoxyflavone, and 5,7,4'-trihydroxy-2',3',5'-trimethoxyflavone were isolated from the leaf exudate of Psiadia punctulata, together with the previously reported 5-hydroxy-7,2',3',4',5'-pentamethoxyflavone and 5,7,3'-trihydroxy-2',4',5'-trimethoxyflavone. The two phenylpropenoids, Z-docosyl-p-coumarate and E-docosyl-p-coumarate were also isolated. The structures were determined on the basis of spectroscopic evidence.
Subject(s)
Asteraceae/chemistry , Coumaric Acids/chemistry , Coumaric Acids/isolation & purification , Flavonoids/chemistry , Flavonoids/isolation & purification , Asteraceae/therapeutic use , Phytotherapy , Plant Leaves/chemistry , Plant Structures/chemistryABSTRACT
Petasides hybridus (butterbur) is a perennial shrub, found throughout Europe as well as parts of Asia and North America, that has been used medicinally for centuries. During the Middle Ages butterbur was used to treat plague and fever; in the 17th century its use was noted in treating cough, asthma, and skin wounds. The plant can grow to a height of three feet and is usually found in wet, marshy ground, in damp forests, and adjacent to rivers or streams. Its downy leaves can attain a diameter of three feet, making it the largest of all indigenous floras, and their unique characteristics are responsible for the plant's botanical and common names. The genus name, Petasites, is derived from the Greek word petasos, which is the felt hat worn by shepherds. The common name of butterbur is attributed to the large leaves being used to wrap butter during warm weather. Other common names include pestwurz (German), blatterdock, bog rhubarb, and butter-dock. Currently, the primary therapeutic uses for butterbur are for prophylactic treatment of migraines, and as an anti-spasmodic agent for chronic cough or asthma. It has also been used successfully in preventing gastric ulcers, and in treating patients with irritable bladder and urinary tract spasms.
Subject(s)
Asteraceae/therapeutic use , Phytotherapy , Plant Extracts/therapeutic use , Asteraceae/adverse effects , Asthma/drug therapy , Bronchitis/drug therapy , Gastrointestinal Diseases/drug therapy , Humans , Migraine Disorders/drug therapy , Plant Extracts/administration & dosage , Plant Extracts/adverse effectsABSTRACT
El presente trabajo presenta la cuarta parte de las compuestas medicinales de la provincia biogeográficaPampeana (este de la Argentina, Uruguay, y mitad austral de Rio Grande do sul en Brasi) ubicadas en el quinto grupo artificial de los siete delimitados en la primera parte del trabajo. Este grupo está caracterizado por sus capítulos con flores dimorfas y papusausente y comprende catorce especies y una variedad,las cuales pertencen a cuatro tribus: Anthemideae (achillea, anthemis, artemisia, matricaria, soliva y tanacetum), Calenduleae (calendula), Helenieae (flaveria) y Heliantheae (acanthospermum y Cosmos). Se brinda una clave para la determinación de las especies y, para cada una de ellas, nombre científico válido, sinónimos, nombres vulgares, distribución geográfica, usos medicinales e iconografía(AU)
Subject(s)
Asteraceae/therapeutic use , Chamomile/classification , Calendula/therapeutic useABSTRACT
El presente trabajo presenta la cuarta parte de las compuestas medicinales de la provincia biogeográficaPampeana (este de la Argentina, Uruguay, y mitad austral de Rio Grande do sul en Brasi) ubicadas en el quinto grupo artificial de los siete delimitados en la primera parte del trabajo. Este grupo está caracterizado por sus capítulos con flores dimorfas y papusausente y comprende catorce especies y una variedad,las cuales pertencen a cuatro tribus: Anthemideae (achillea, anthemis, artemisia, matricaria, soliva y tanacetum), Calenduleae (calendula), Helenieae (flaveria) y Heliantheae (acanthospermum y Cosmos). Se brinda una clave para la determinación de las especies y, para cada una de ellas, nombre científico válido, sinónimos, nombres vulgares, distribución geográfica, usos medicinales e iconografía
Subject(s)
Asteraceae/therapeutic use , Calendula/therapeutic use , Chamomile/classificationABSTRACT
1. The anti-inflammatory effect of an alcoholic extract from the flower of Vernonia cinerea (Asteraceae; Less) was tested in adjuvant arthritic rats. 2. Changes in paw volume, body and tissue weights and serum and tissue enzyme activities of ALT, AST, ACP and cathepsin-D in adjuvant rats were reversed by oral administration of 100 mg/kg body weight (BW) of the flower extract. 3. The extract also reversed the major histopathological changes in the hindpaws of the arthritic rats. 4. Phytochemical studies revealed the presence of alkaloids, saponins, steroids and flavonoids. 5. It is concluded that the extract contains as yet unidentified anti-inflammatory principle(s).
