1.
Mutat Res
; 104(6): 339-44, 1982 Jul.
Article
in English
| MEDLINE
| ID: mdl-7050687
ABSTRACT
In previous experiments, azaperone was found to be weakly mutagenic, after metabolic activation, in the Ames assay. In this study, we subjected metabolites found in rat and swine to the Salmonella/microsome test. 5 histidine-auxotrophic strains were used. The main metabolites could be classified as weakly mutagenic substances.
Subject(s)
Azaperone/analogs & derivatives , Azaperone/pharmacology , Butyrophenones/pharmacology , Microsomes, Liver/metabolism , Mutagens , Mutation , Animals , Azaperone/metabolism , Biotransformation , Mutagenicity Tests , Rats , Rats, Inbred Strains , Salmonella typhimurium/drug effects , Species Specificity
2.
Toxicol Appl Pharmacol
; 35(2): 333-9, 1976 Feb.
Article
in English
| MEDLINE
| ID: mdl-1265750
