1.
Biull Eksp Biol Med
; 105(1): 77-80, 1988 Jan.
Article
in Russian
| MEDLINE
| ID: mdl-3337887
ABSTRACT
The phenomenon of total replacement of preexisting and damaged hepatocytes in mice were demonstrated by the method of autoradiography. Adult mice were injected an alkylating drug Dipin 2 h prior to partial hepatectomy and then proliferating cells were labelled by means of multiple injections of 14C-thymidine. Dipin in combination with mitotic stimulation induced multiple mitotic aberrations in proliferating hepatocytes resulting in degeneration, death and then elimination of prelabelled liver cells. New parenchymal tissue originated from non-labelled preneoplastic nodules. These hepatocyte nodules grew in size, propagated and 8-10 months later completely replaced the preexisting hepatocytes.
Subject(s)
Alkylating Agents/poisoning , Aziridines/poisoning , Azirines/poisoning , Hepatectomy , Liver/pathology , Animals , Liver/drug effects , Liver/surgery , Liver Neoplasms/pathology , Mice , Mitosis/drug effects , Precancerous Conditions/pathology
2.
Gig Tr Prof Zabol
; 18(1): 41-2, 1974 Jan.
Article
in Russian
| MEDLINE
| ID: mdl-4839823
3.
Gig Tr Prof Zabol
; 14(9): 46-7, 1970 Sep.
Article
in Russian
| MEDLINE
| ID: mdl-5483799
4.
Ann Rheum Dis
; 29(5): 546-52, 1970 Sep.
Article
in English
| MEDLINE
| ID: mdl-5476682
Subject(s)
Kidney Diseases/chemically induced , Urine/cytology , Acute Kidney Injury/chemically induced , Animals , Aspirin/poisoning , Azirines/poisoning , Chromates/poisoning , Eosinophils , Histocytochemistry , Kidney Diseases/pathology , Kidney Tubules/pathology , Male , Mercury Poisoning , Quaternary Ammonium Compounds/poisoning , Rats , Serine/poisoning , Uranium/poisoning
5.
Farmakol Toksikol
; 32(5): 614-5, 1969.
Article
in Russian
| MEDLINE
| ID: mdl-5364686
Subject(s)
Azirines/poisoning , Thiosulfates/therapeutic use , Acute Disease , Animals , Azirines/administration & dosage , Azirines/antagonists & inhibitors , Depression, Chemical , Injections, Intraperitoneal , Injections, Intravenous , Kidney/pathology , Liver/pathology , Lung/pathology , Myocardium/pathology , Poisoning/drug therapy , Rabbits , Rats , Spleen/pathology , Thiosulfates/administration & dosage , Time Factors
6.
Klin Med (Mosk)
; 46(1): 142-3, 1968 Jan.
Article
in Russian
| MEDLINE
| ID: mdl-5656951