1.
Carbohydr Res
; 193: 105-13, 1989 Oct 31.
Article
in English
| MEDLINE
| ID: mdl-2575452
ABSTRACT
The condensation of per(trimethyl)silylbarbital and -phenobarbital with 1,2,3,4,6-penta-O-acetyl-beta-D-glucopyranose in the presence of stannic chloride in dichloroethane gave moderate yields of the beta-coupled barbiturate N-D-glucopyranosyl derivatives. Reaction of metharbital and mephobarbital under the same conditions was unsuccessful. The homologous N-methylglucosides were prepared by reaction of the barbital and phenobarbital N-glucosyl derivatives with diazomethane. The diastereomers of the phenobarbital and mephobarbital derivatives were resolved by use of C-18 reverse-phase h.p.l.c. 1H- and 13C-n.m.r. spectroscopy, and thermospray 1.c.-m.s. proved to be the most useful methods for characterizing the barbiturate glucosides.
Subject(s)
Barbiturates/chemical synthesis , Barbital/analogs & derivatives , Barbital/chemical synthesis , Barbiturates/analogs & derivatives , Chromatography, High Pressure Liquid , Disaccharides/chemical synthesis , Magnetic Resonance Spectroscopy , Mephobarbital/analogs & derivatives , Mephobarbital/chemical synthesis , Phenobarbital/analogs & derivatives , Phenobarbital/chemical synthesis
2.
Int J Appl Radiat Isot
; 32(11): 843-5, 1981 Nov.
Article
in English
| MEDLINE
| ID: mdl-7309275
Subject(s)
Anticonvulsants/chemical synthesis , Barbital/chemical synthesis , Barbiturates/chemical synthesis , Carbon Radioisotopes , Hydantoins/chemical synthesis , Isotope Labeling , Mephenytoin/analogs & derivatives , Mephenytoin/chemical synthesis , Phenobarbital/chemical synthesis , Phenytoin/chemical synthesis
3.
Farm Zh
; 30(6): 45-7, 1975.
Article
in Ukrainian
| MEDLINE
| ID: mdl-1213110