1.
Jpn J Pharmacol
; 65(2): 175-7, 1994 Jun.
Article
in English
| MEDLINE
| ID: mdl-7967231
ABSTRACT
S-312, S-312-d, but not S-312-l, L-type calcium channel antagonists, showed anticonvulsant effects on the audiogenic tonic convulsions in DBA/2 mice; and their ED50 values were 18.4 (12.8-27.1) mg/kg, p.o. and 15.0 (10.2-23.7) mg/kg, p.o., respectively, while that of flunarizine was 34.0 (26.0-44.8) mg/kg, p.o. Although moderate anticonvulsant effects of S-312-d in higher doses were observed against the clonic convulsions induced by pentylenetetrazole (85 mg/kg, s.c.) or bemegride (40 mg/kg, s.c.), no effects were observed in convulsions induced by N-methyl-D-aspartate, picrotoxin, or electroshock in Slc:ddY mice. S-312-d may be useful in the therapy of certain types of human epilepsy.
Subject(s)
Anticonvulsants/therapeutic use , Calcium Channel Blockers/therapeutic use , Dihydropyridines/therapeutic use , Seizures/drug therapy , Administration, Oral , Animals , Anticonvulsants/administration & dosage , Bemegride/administration & dosage , Bemegride/toxicity , Calcium Channel Blockers/administration & dosage , Dihydropyridines/administration & dosage , Disease Models, Animal , Electroshock , Female , Injections, Subcutaneous , Male , Mice , Mice, Inbred DBA , N-Methylaspartate/administration & dosage , N-Methylaspartate/toxicity , Pentylenetetrazole/administration & dosage , Pentylenetetrazole/toxicity , Picrotoxin/administration & dosage , Picrotoxin/toxicity , Seizures/chemically induced
2.
Acta Univ Palacki Olomuc Fac Med
; 106: 39-46, 1984.
Article
in English
| MEDLINE
| ID: mdl-6242622
3.
Acta Univ Palacki Olomuc Fac Med
; 106: 47-56, 1984.
Article
in English
| MEDLINE
| ID: mdl-6242623