Subject(s)
Acidosis, Lactic/diagnosis , Beriberi/diagnosis , Colitis, Ulcerative/diagnosis , Parenteral Nutrition, Total/adverse effects , Severity of Illness Index , Acidosis, Lactic/blood , Acidosis, Lactic/chemically induced , Adolescent , Beriberi/blood , Beriberi/chemically induced , Colitis, Ulcerative/blood , Colitis, Ulcerative/therapy , Humans , MaleABSTRACT
A 45-year-old male alcoholic with a deficient diet was given salbutamol for exertion-related dyspnoea. After inhalation, he presented with a severe dyspnoea, acrocyanosis, anuria and low blood pressure as well as a respiratory compensated lactate acidosis. Shoshin beriberi was suspected on clinical grounds. The low level of thiamine and the prompt recovery after thiamine repletion confirmed this diagnosis. Shoshin beriberi is an acute, cardiac form of beriberi, which can rapidly result in death due to cardiogenic shock and lactate acidosis. Adrenergic agents can cause a hyperdynamic circulation and thus aggravate the effects of a thiamine deficiency.
Subject(s)
Albuterol/adverse effects , Beriberi/diagnosis , Bronchodilator Agents/adverse effects , Thiamine/therapeutic use , Acidosis, Lactic/diagnosis , Acidosis, Lactic/etiology , Acute Disease , Administration, Inhalation , Albuterol/administration & dosage , Beriberi/chemically induced , Beriberi/complications , Beriberi/drug therapy , Bronchodilator Agents/administration & dosage , Cardiac Output, Low/diagnosis , Cardiac Output, Low/etiology , Humans , Male , Middle Aged , Thiamine Deficiency/complications , Thiamine Deficiency/drug therapyABSTRACT
A 21 month old female had voluntarily ingested 0.5-1.51 of isotonic sports drink daily from 10 months of age. She developed hyponatremia and beriberi heart disease, which resulted in metabolic acidosis and cardiogenic shock (shoshin beriberi). Mechanical ventilation was applied for pulmonary edema. Right heart failure was improved after administering vitamin B1. However, 5 days after the shock, hypoxemia and diffuse radiographic infiltrates progressed, and a diagnosis of adult respiratory distress syndrome (ARDS) was made. After the occurrence of an air leak, the patient died of respiratory failure. The cardiogenic shock and pulmonary edema due to cardiac beriberi may have triggered the ARDS.
Subject(s)
Beriberi/chemically induced , Beverages/adverse effects , Heart Diseases/chemically induced , Isotonic Solutions/adverse effects , Respiratory Distress Syndrome/etiology , Shock, Cardiogenic/etiology , Beriberi/complications , Female , Heart Diseases/complications , Heart Diseases/diagnostic imaging , Humans , Infant , Radiography , Respiratory Distress Syndrome/diagnostic imagingSubject(s)
Anticonvulsants/adverse effects , Avitaminosis/chemically induced , Ascorbic Acid Deficiency/chemically induced , Beriberi/chemically induced , Child, Preschool , Female , Heart Diseases/chemically induced , Humans , Phenobarbital/adverse effects , Phenytoin/adverse effects , Primidone/adverse effects , Rickets/chemically inducedABSTRACT
The review paper summarizes our knowledge on the influence of the intake of mycotoxin containing foodstuffs on human health. The greatest attention is given to the aflatoxins. The results of epidemiological studies on the occurrence of primary liver cancer in Thailand and different regions of middle and southern Africa are described.
