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Anal Chem ; 81(5): 1976-81, 2009 Mar 01.
Article in English | MEDLINE | ID: mdl-19173588

ABSTRACT

Here we report the fabrication of two types of microirradiators, consisting of a recessed disk and protruding wire with low-beta-energy radionuclide Ni-63 electrodeposited onto a 25 microm diameter Pt wire. Ni-63 is constricted to a small surface area of the microelectrode; hence, this tool provides a means of delivery of localized, large dose density of beta radiation to the object but a minimal dose exposure to the user. The activity levels of Ni-63 emitted from the recessed disk and protruding wire are 0.25 and 1 Bq, respectively. The corresponding beta particles flux levels emitted from the recessed disk and protruding wire are 51 and 11 kBq/cm(2), respectively. These values, measured experimentally using liquid scintillation counting, fit very well the expected values of activity for each microirradiator, calculated considering the self-absorption effect, typical for low-energy beta particles. In order to determine the optimal configuration the dose rates for varying distances from the object were calculated.


Subject(s)
Beta Particles/therapeutic use , Nickel/therapeutic use , Radiation Dosage , Radioisotopes/therapeutic use , Beta Particles/classification , Dose-Response Relationship, Radiation , Monte Carlo Method , Nickel/toxicity , Radiation Monitoring , Radiation Protection , Radioisotopes/toxicity , Radiopharmaceuticals/therapeutic use , Radiopharmaceuticals/toxicity , Risk Assessment , Scintillation Counting
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