Poxviruses as Agents of Biological Warfare: The Importance of Ensuring Ethical Standards for Research with Viruses.

Historically, biological agents have been used to target various populations. One of the earliest examples could be the catastrophic effect of smallpox in Australia in the eighteenth century (as alleged by some historians). Modern biological techniques can be used to both create or provide protection against various agents of biological warfare. Any microorganism (viruses, bacteria, and fungi) or its toxins can be used as biological agents. Minnesota Department of Health has listed Smallpox (variola major) as a category A bioterrorism agent, even though it has been eradicated in 1980 through an extensive vaccination campaign. Category A agents are considered the highest risk to public health. Laboratory-associated outbreaks of poxviruses could cause unprecedented occupational hazards. Only two WHO-approved BSL-4 facilities in the United States and Russia are allowed to perform research on the variola virus. So, poxviruses present themselves as a classical case of a dual-use dilemma, since research with them can be used for both beneficial and harmful purposes. Although the importance of ethics in scientific research requires no further elaboration, ethical norms assume greater significance during experimentation with poxviruses. In this chapter, we will update the readers on the sensitive nature of conducting research with poxviruses, and how these viruses can be a source of potential biological weapons. Finally, specified ethical guidelines are explored to ensure safe research practices in virology.

Bioterrorismo y armas biológicas: caracterización y respuesta frente a las amenazas actuales / Bioterrorism and biological weapons: characterization and response to current threats

El uso de agentes biológicos con fines terroristas constituye una amenaza singular. Aunque poco probable, su materialización puede ser difícilmente evitable en el futuro. Este artículo revisa el fenómeno del bioterrorismo, examinando los posibles riesgos y vulnerabilidades, los mecanismos de respuesta y las nuevas amenazas para la bioseguridad. (AU)

The use of biological agents for terrorist purposes is a unique threat. Although unlikely, it may be difficult to prevent in the future. This article provides an overview of the phenomenon of bioterrorism, examining potential risks and vulnerabilities, response mechanisms and emerging threats to biosecurity. (AU)

[Human experiment study of Unit 731, Japan: take the report "The Research Report on Epidemic Prevention of Army Medical School â ¡: Vol.1, No.36 " as an example].

"The Research Report on Epidemic Prevention of Army Medical School Ⅱ: Vol.1, No.36" , the report named "various symptoms and serological responses of human body after receiving ultrasonic cholera vaccine" is one of the declassified materials of Japanese biological warfare. The author is M. D. Watanabe Be. Through detailed analysis of its contents, such as institute of report, test method, test results, and so forth, conclusion is reached that Unit 731 did conduct scientific research based on human-subject experiment to launch biological warfare on human beings. The report mentioned above is one of the most important evidence of crime that Japan conducts biological warfare which violates international convention and contempt bottom line of human basic morals and ethics.

Bioética e armas biológicas no contexto internacional / Bioethics and biological weapons in the international context

O estudo "Bioética e Armas Biológicas no Contexto Internacional" investiga a aplicação de análise sob a ótica da bioética de intervenção a diálogos internacionais no âmbito de um sistema de estados. O estudo de caso testa o método de investigação que consiste na identificação de valores e posicionamentos contratantes entre países desenvolvidos e em desenvolvimento e suas possibilidades de incorporação a regras, normas e regulações adotadas pela comunidade internacional. Nesse processo é verificado o equilíbrio de oportunidades entre países do Norte e do Sul para inserirem suas necessidades e interesses nas normas de convivência entre Estados como indicativo das condições de justiça e equidade no âmbito do diálogo internacional. As armas biológicas são tomadas como estudo de caso por sua relação intrínseca com a saúde e com a integridade de populações vulneráveis dos países periféricos

The study "Bioethics and biological weapons in an international context" investigates the application of an analysis from the perspective of intervention bioethics to international dialogues within a system of States. The case study tests the research method which consists in identifying and contrasting positions between developed and developing countries and their possibilities of their incorporation to rules, standards and regulations adopted by the international community. The analysis also considers the balance of opportunities between countries from the North and the South to insert their needs and interests in the rules of coexistence among States as indicative of the conditions of justice and equity in international dialogue. Biological weapons are taken as a case study for its intrinsic relationship with human health and the health of vulnerable populations of peripheral countries

A question of control.

Scientists must address the ethics of using neuroactive compounds to quash domestic crises.

Biologists napping while work militarized.

As researchers discover more agents that alter mental states, the Chemical Weapons Convention needs modification to help ensure that the life sciences are not used for hostile purposes, says Malcolm Dando.

Smarter regulations: commentary on "Responsible conduct by life scientists in an age of terrorism".

In the United States a rapidly increasing regulatory burden for life scientists has led to questions of whether the increased burden resulting from the Select Agent Program has had adverse effects on scientific advances. Attention has focussed on the regulatory "fit" of the Program and ways in which its design could be improved. An international framework convention to address common concerns about biosecurity and biosafety is a logical next step.

Responsible conduct by life scientists in an age of terrorism.

The potential for dual use of research in the life sciences to be misused for harm raises a range of problems for the scientific community and policy makers. Various legal and ethical strategies are being implemented to reduce the threat of the misuse of research and knowledge in the life sciences by establishing a culture of responsible conduct.

O desenvolvimento biológico em conexão com a guerra / The Biological development in connection with the war

O século XX foi cenário da construção de um sistema para a operacionalização da ciência estratégica das grandes potências, chamada Big Science. Este sistema é constituído por uma vasta rede institucional integrada, o "complexo militar-industrial-acadêmico", que desenvolve pesquisas estratégicas e direciona a ciência de ponta. O objetivo deste estudo foi investigar a lógica desta construção sob a ótica do poder, fazendo um contraponto entre os desenvolvimentos tecnológicos da Física e da Biologia. Os movimentos de poder identificam algumas características que, em tese, refletem o incentivo para indução do desenvolvimento científico da modernidade, potencializado na era atômica com a fabricação de armas de destruição em massa, as armas de alta tecnologia. Nesta perspectiva, buscamos a relevância do desenvolvimento biológico de interesse político-militar, tomando por base a fabricação de três gerações de armas ao longo do século XX, com crescente posicionamento na corrida armamentista. Esta análise envolve as décadas de 1940 até 1980, na busca de demonstrar uma convergência técnico-política nas trajetórias do desenvolvimento biológico e da guerra biológica, que culminou numa conexão científico-militar no início da era biotecnológica.

The XX Century was the scenario for the construction of a system devoted to operationalizing the strategic science of the great potentials named the Big Science. This system comprehends a vast institutional and integrated network, the "military-industrial-academic complex", which carries out strategic research and guides high quality science. The objective of this study was to investigate the logics of such construction under the perspective of power, highlighting a counterpoint between the technological development of Physics and Biology. The power movement points to some characteristics, that theoretically reflect the incentive to the induction of the scientific development of modern times, potentialized during the atomic age by the manufacturing of high technology weapons. In this perspective one can search the relevance of the biological development of political-military interest in the three-generation manufacturing of weapons throughout the XX Century, and the participation in the armaments race. This historiographic analysis encompasses the decades of 1940 through 1980, in an attempt to show the ethnical-political convergence in the paths taken by the biological development and the biological war which eventually led to a scientific and military connection at the beginning of the biotechnological era.