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Bioorg Med Chem Lett ; 20(19): 5772-5, 2010 Oct 01.
Article in English | MEDLINE | ID: mdl-20800481

ABSTRACT

Design, synthesis and cytotoxicity of several known and novel biurets against human breast cancer T47D cell line in comparison to doxorubicin are described. Biurets incorporating 2-methyl quinoline-4-yl and benzo[d]thiazol-2-ylthio moieties showed higher cytotoxicity and decreased cell viability in a concentration- and time-dependent manner.


Subject(s)
Antineoplastic Agents/chemical synthesis , Biuret/chemistry , Antineoplastic Agents/therapeutic use , Antineoplastic Agents/toxicity , Biuret/therapeutic use , Biuret/toxicity , Breast Neoplasms/drug therapy , Cell Line, Tumor , Female , Humans , Structure-Activity Relationship
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