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1.
Rev. clín. esp. (Ed. impr.) ; 214(3): 145-149, abr. 2014.
Article in Spanish | IBECS | ID: ibc-121177

ABSTRACT

Algunos enfermos con ictus isquémico que siguen tratamiento con aspirina como antiagregante presentan un nuevo ictus isquémico. Estos pacientes han sido llamados «resistentes» o «no respondedores a la aspirina» (15-25%). En ellos el riesgo de presentar un ictus es 4 veces mayor. Además, los ictus suelen ser más graves, con mayor área infartada y con mayor riesgo de recurrencia. Actualmente no existe una prueba de laboratorio ideal para detectar la resistencia al efecto antiagregante de la aspirina. El estudio de resistencia a la aspirina solo estaría indicado en casos seleccionados y es obligado descartar la «pseudorresistencia» a la aspirina (falta de cumplimiento, tratamientos concomitantes que interfieren con la acción de la aspirina) (AU)


Some patients with a ischemic stroke who are being treated with aspirin as an antiaggregant suffer a new ischemic stroke. These patients (15 to 25%) have been called unresponsive to aspirin or aspirin resistant. The aspirin-resistant patients have a four-time greater risk of suffering a stroke. Furthermore, these strokes are generally more severe, with increased infarct volume and greater risk of recurrence. There is currently no ideal laboratory test to detect the resistance to the antiaggregant effect of aspirin. The study of resistance to aspirin would only be indicated in selected cases. In these patients, one should first rule out any «pseudo-resistance» to aspirin (lack of compliance, concomitant treatments that interfere with the action of the aspirin (AU)


Subject(s)
Humans , Male , Female , Stroke/complications , Stroke/drug therapy , Drug Resistance , Drug Resistance/physiology , Secondary Prevention/methods , Secondary Prevention/trends , Bleeding Time/trends , Aspirin/therapeutic use , Platelet Aggregation Inhibitors/therapeutic use , Secondary Prevention/organization & administration , Secondary Prevention/standards
2.
Trauma (Majadahonda) ; 23(2): 70-76, abr.-jun. 2012. tab, ilus
Article in Spanish | IBECS | ID: ibc-100909

ABSTRACT

Objetivo: Evaluar la cantidad del sangrado por los drenajes en las fracturas pertrocantéricas de fémur en el tiempo, durante el postoperatorio inmediato, para saber el momento más apropiado para retirarlos. Pacientes y métodos: Estudio descriptivo, longitudinal y unicéntrico de una cohorte prospectiva de pacientes consecutivos intervenidos de fractura pertrocantérica de fémur, tratada con una osteosíntesis con tornillo y placa deslizante. Se incluyeron 100 pacientes, con edad media de 86 (DE: 8) años; el 74% fueron mujeres. En 96 casos se colocó un drenaje profundo y en 17 superficial. La variable principal fue el sangrado postoperatorio de los drenajes que se recogieron horariamente durante las tres primeras horas del postoperatorio, a las 24 y 48 horas antes de retirarlos. Resultados: El sangrado medio intraoperatorio fue de 278,1 (DE: 148,2) mL y el sangrado total medio postoperatorio de 76,2 (DE: 83,4) mL. El 74% de los pacientes sangraron durante las primeras 24 horas y el 52% lo hicieron hasta las 48 horas. Requirieron transfusión sanguínea perioperatoria 68 pacientes. Conclusión: El sangrado postoperatorio de los pacientes con fractura pertrocantérica de fémur es bajo. Tan solo unos pocos pacientes se beneficiarían del uso de drenajes, por lo que cabría evaluar el riesgo-beneficio de no utilizarlos (AU)


Objective: To evaluate the blood loss intraoperatively and through the drainages during the postoperative procedure of pertrochanteric femoral fractures, in order to know when is appropriated time to take them out. Patients and methods: A descriptive, longitudinal and unicenter study of a prospective and consecutive cohort of patients with pertrochanteric femoral fracture treated with a Dynamic Hip Screw. 100 patients were included, with a mean age 86 (DE: 8) years old; 74% were women. Deep drainages were inserted in 96 and superficial drainages in 17 cases. The principal outcome was the blood loss collected through the drainages during the first three hours of the postoperative, at 24 hours and at 48 hours. Results: The mean intraoperative blood loss was 278.1 (SD: 148.2) mL, and the mean blood loss through the drainages during the postoperative period was 76,2 (SD: 83.4) mL. Within the first postoperative 24 hours, 74% of the patients had blood losses whereas 52% did so within 48 hours. Sixty eight patients required blood transfusion. Conclusion: The main postoperative blood loss in the pertrochanteric fracture is small. A few patients can take benefit of drainages, therefore if we not use them, it would be advisable to perform a risk-benefit analysis (AU)


Subject(s)
Humans , Male , Female , Hip Fractures/diagnosis , Hip Fractures/surgery , Drainage/trends , Bleeding Time/trends , Fracture Fixation, Intramedullary/methods , Fracture Fixation, Intramedullary , Femoral Fractures/diagnosis , Femoral Fractures/surgery , Cohort Studies , Hip Fractures/complications , Hip Fractures , Prospective Studies , Postoperative Period , Data Collection/methods , Data Collection
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