Subject(s)
Amyloidosis , Blister , Humans , Amyloidosis/diagnosis , Amyloidosis/complications , Blister/etiology , Blister/diagnosis , Immunoglobulin Light Chains , Male , Female , Oral Hemorrhage/etiology , Oral Hemorrhage/diagnosis , Aged , Immunoglobulin Light-chain Amyloidosis/diagnosis , Immunoglobulin Light-chain Amyloidosis/complications , Middle AgedSubject(s)
Blister , Cornea , Humans , Blister/diagnosis , Blister/etiology , Intraocular Pressure , MassageABSTRACT
A woman in her 80s presented with erythematous, nondesquamative, annular plaques in a cluster of jewels pattern on her wrists and legs. What is your diagnosis?
Subject(s)
Blister , Skin Abnormalities , Humans , Blister/diagnosis , Blister/etiology , Erythema/diagnosis , Erythema/etiologyABSTRACT
A female child presents for 3-year follow-up with erythema, vesicles, and bullae present since birth and an increasing number of annular hyperkeratotic plaques and palmoplantar hyperkeratosis. What is your diagnosis?
Subject(s)
Blister , Skin Abnormalities , Female , Infant, Newborn , Humans , Blister/diagnosis , Blister/etiology , Erythema/diagnosis , Erythema/etiologyABSTRACT
We describe a rare presentation of congenital bullous syphilis in a premature neonate born with extensive skin desquamation. The newborn was noted to have diffuse erythema with widespread, superficial skin desquamation in addition to plantar bullae and erosions, and an absence of mucosal involvement. Immunohistochemical syphilis diagnostic staining was performed on a blister roof, highlighting a novel diagnostic approach for congenital bullous syphilis.
Subject(s)
Infant, Newborn, Diseases , Syphilis, Congenital , Syphilis , Infant, Newborn , Humans , Blister/diagnosis , Syphilis, Congenital/diagnosis , ErythemaABSTRACT
Autoimmune blistering diseases (AIBD) comprise a heterogeneous group of uncommon disorders of the skin and mucous membranes, characterised by antibodies targeting structural proteins within epithelial tissue and the underlying basement membrane. There can be significant overlap in clinical presentation of these diseases and accurate diagnosis relies on the detection and characterisation of relevant autoantibodies. Immunofluorescence provides the gold-standard diagnostic tool for these diseases, identifying both tissue-bound autoantibodies in biopsy material using direct immunofluorescence and circulating antibodies in serum through indirect immunofluorescence. Following advances in the identification and subsequent characterisation of numerous antigenic targets in these diseases, the development of antigen-specific tests, in particular, enzyme-linked immunosorbent assays on serum specimens, has provided a third key tool to not only identify, but also quantify AIBD autoantibodies. This quantification has proven particularly useful in monitoring disease activity and informing clinical management decisions. Accurate diagnosis of these diseases is important since optimal treatment strategies differ between them and, prognostically, some diagnoses are associated with an increased risk of malignancy. This review outlines the molecular pathology underlying the major AIBD and describes how the three principal techniques can be used in combination, to provide best practice for diagnosis and treatment monitoring.
Subject(s)
Autoimmune Diseases , Humans , Autoimmune Diseases/diagnosis , Blister/diagnosis , Blister/pathology , Autoantibodies , Enzyme-Linked Immunosorbent AssayABSTRACT
We report a case of phytophotodermatitis caused by cow parsnip (Heracleum maximum) exposure affecting a hiker in Colorado. Phytophotodermatitis is a phototoxic skin reaction to UV-A rays after contact with photosensitizing plant substances that presents as a burning, painful rash, often with blisters. Treatment is supportive, including wound hygiene, analgesia, and anti-inflammatories. Avoiding offending plants, protecting the skin from sun, and immediate washing with soap and water after plant contact are the primary means of prevention. We have included a table and photos of plants found in the United States that can cause phytophotodermatitis. Medical providers should include phytophotodermatitis in the differential diagnosis of blistering rashes in patients who have been outdoors with possible exposure to offending plants.
Subject(s)
Dermatitis, Phototoxic , Humans , Dermatitis, Phototoxic/diagnosis , Dermatitis, Phototoxic/etiology , Blister/diagnosis , Blister/etiology , Diagnosis, Differential , ColoradoSubject(s)
Skin Diseases , Soft Tissue Injuries , Male , Humans , Blister/diagnosis , Blister/etiologySubject(s)
Humans , Female , Child , Blister/diagnosis , Blister/drug therapy , Coma/complications , Cerebral Palsy , Respiratory InsufficiencyABSTRACT
CASE PRESENTATION: A 75-year-old man presented to our hospital with cough and sputum for more than a year. Eight months previously, the patient was admitted to a local hospital, and his symptoms were relieved after symptomatic treatment (expectorants and antitussives). Three months ago, he was admitted to our hospital, and his symptoms improved with antiinflammatory therapy. He had a 30-pack-years history of smoking (20 cigarettes/day) and a history of drinking (200 g liquor per day). The patient had no history of genetic disorders or cancer. He did not present with fever, dyspnea, hemoptysis or chest distress, and there was no history of weight loss since onset.
