1.
Life Sci
; 42(21): 2131-6, 1988.
Article
in English
| MEDLINE
| ID: mdl-3386397
ABSTRACT
Nineteen phenothiazines were tested for in vitro inhibition of human platelet type B monoamine oxidase (MAO). The inhibition potency was highly dependent on structures of their side chains. The inhibition was most potent for drugs with (hydroxyethyl-piperazinyl)propyl chains followed in decreasing order by those with (N-methylpiperazinyl)propyl, (2-dimethylamino-2-methyl)ethyl and 3-dimethylaminopropyl chains. Kinetic analyses were carried out for promazine, promethazine, perazine and perphenazine as representatives of each group; the four drugs showed competitive inhibition, and Ki values of 124, 31.4, 19.2 and 22.6 microM, respectively.
Subject(s)
Blood Platelets/injuries , Monoamine Oxidase/metabolism , Phenothiazines/pharmacokinetics , Humans , In Vitro Techniques , Perazine/pharmacokinetics , Perphenazine/pharmacokinetics , Promazine/pharmacokinetics , Promethazine/pharmacokinetics
2.
Ultrasound Med Biol
; 2(4): 311-7, 1977.
Article
in English
| MEDLINE
| ID: mdl-867566