ABSTRACT
The sustained release of antibiotics from bone cement provides an opportunity for the induction of hypersensitivity. We evaluated the cellular and humoral immune responsiveness of guinea pigs to antibiotics diffusing from bone cement. We were unable to detect the presence of antibodies or skin hypersensitivity to any of the antibiotics tested.
Subject(s)
Anti-Bacterial Agents/immunology , Bone Cements/immunology , Drug Hypersensitivity/etiology , Animals , Anti-Bacterial Agents/urine , Diffusion , Guinea Pigs , In Vitro Techniques , Skin TestsABSTRACT
After the fact that femoral osteotomy in rats results in destruction of the entire bone (in the majority of experimental animals) due to an immunological reaction by means of Complete Freund's Adjuvant, we have investigated whether or not the implantation of bone cement or Kirschner wires affects additionally the condition of the bone. We have found that bone cement or metallic material within the bone cavity aggravates osteolysis if there is an immunologic reaction present. The conditions of the immunologic mechanism and the applied orthopedic procedures are discussed and an attempt has been made to explain the phenomenon.
