Subject(s)
Acetaminophen/adverse effects , Antitussive Agents/adverse effects , Bromisovalum/adverse effects , Codeine/analogs & derivatives , Diphenhydramine/adverse effects , Drug Eruptions/diagnosis , Drug Eruptions/etiology , Dyphylline/adverse effects , Ephedrine/analogs & derivatives , Acetaminophen/administration & dosage , Administration, Oral , Adolescent , Antitussive Agents/administration & dosage , Bromisovalum/administration & dosage , Codeine/administration & dosage , Codeine/adverse effects , Diphenhydramine/administration & dosage , Drug Combinations , Dyphylline/administration & dosage , Eosinophils/immunology , Ephedrine/administration & dosage , Ephedrine/adverse effects , Female , Humans , Immunization , Skin Tests , TabletsSubject(s)
Brain Injuries , Bromisovalum/adverse effects , Hypnotics and Sedatives/adverse effects , Psychoses, Substance-Induced/physiopathology , Bromisovalum/administration & dosage , Humans , Hypnotics and Sedatives/administration & dosage , Male , Middle Aged , Psychoses, Substance-Induced/drug therapy , Substance-Related Disorders/complications , Taiwan , Treatment OutcomeSubject(s)
Barbiturates/blood , Bromisovalum/blood , Drug Monitoring/methods , Hypnotics and Sedatives/blood , Barbiturates/administration & dosage , Barbiturates/adverse effects , Barbiturates/pharmacokinetics , Biomarkers/blood , Bromisovalum/administration & dosage , Bromisovalum/adverse effects , Bromisovalum/pharmacokinetics , Chromatography, High Pressure Liquid , Drug Interactions , Humans , Hypnotics and Sedatives/administration & dosage , Hypnotics and Sedatives/adverse effects , Hypnotics and Sedatives/pharmacokinetics , Reference Values , Specimen HandlingABSTRACT
We present the first case (to our knowledge) of acetaminophen-induced eosinophilic pneumonia. Although the patient had taken an acetaminophen-containing combination drug, Kinuya-chinnetsu, for only three days, the abnormal shadow on his chest radiograph continued for about a month. Lymphocyte stimulation tests showed that both Kinuya-chinnetsu and acetaminophen induced the proliferation of peripheral blood lymphocytes.
Subject(s)
Acetaminophen/adverse effects , Pulmonary Eosinophilia/chemically induced , Acetaminophen/administration & dosage , Bromisovalum/administration & dosage , Caffeine/administration & dosage , Caffeine/adverse effects , Drug Combinations , Drug Eruptions/etiology , Eosinophilia/chemically induced , Humans , Lymphocyte Activation/drug effects , Male , Middle AgedABSTRACT
A gas chromatography-selected ion monitoring procedure with chemical ionization is described for the determination of bromovalerylurea (BVU) in human plasma. BVU was extracted with ether after addition of 2-bromo-2-methylpropylurea as an internal standard. The lower limit of BVU quantification by this method was 2 ng/0.1 ml plasma volume. This procedure was used to determine the sequential plasma levels of BVU in a human volunteer following a single oral dose of a commercial analgesic.
