1.
Health Phys
; 37(6): 729-34, 1979 Dec.
Article
in English
| MEDLINE
| ID: mdl-544558
Subject(s)
Chelating Agents/metabolism , Liver/metabolism , Plutonium/metabolism , Animals , Bone and Bones/metabolism , Bufexamac/metabolism , Chromones/metabolism , Cricetinae , Deferoxamine/analogs & derivatives , Deferoxamine/metabolism , Female , Glycine/analogs & derivatives , Glycine/metabolism , Hydroxamic Acids/metabolism , Mesocricetus , Pentetic Acid/metabolism , Piperazines/metabolism , Pyridines/metabolism
2.
Arzneimittelforschung
; 28(6): 1021-3, 1978.
Article
in German
| MEDLINE
| ID: mdl-581998
ABSTRACT
The penetration of p-butoxyphenylacetohydroxamic acid (BPHS; Parfenac) from a crean and an ointment into human skin in vivo and in vitro was investigated. From both preparation forms high tissue concentrations were achieved. Flow rates through the horny layer could be calculated, that from the ointment being considerably higher (3.8 . 10(-8) mol/cm2 . h) than that from the cream (7 . 10(-9) mol/cm2 . h). A control experiment in vivo proved that the in vitro data are relevant. The difference between dermal concentrations in vitro (with abolished capillary function) and that in vitro (with capillary system functioning) reflected the fast absorption of the drug by the vessels.
Subject(s)
Anti-Inflammatory Agents/metabolism , Bufexamac/metabolism , Hydroxamic Acids/metabolism , Skin Absorption , Administration, Topical , Capillaries , Humans , In Vitro Techniques , Skin/blood supply
3.
Drugs
; 10(5-6): 351-6, 1975.
Article
in English
| MEDLINE
| ID: mdl-1204506