ABSTRACT
BACKGROUND: In chronic wounds, especially burn scars, malignant tumors can arise. However, it is rare for a subacute burn injury to change to a malignant lesion within one month. Moreover, a case of squamous cell carcinoma arising from HeNe laser therapy after a chemical burn has never been reported. CASE REPORT: In this report, we examine a rare case of squamous cell carcinoma arising from HeNe laser therapy after a chemical burn. Because pathologic investigations were made from the first operation, both early detection of the squamous cell carcinoma and consideration of the HeNe laser therapy as a risk factor for the skin cancer were possible. The cancer was completely removed and reconstruction of the defect was successfully achieved in a timely manner. CONCLUSION: Although there has as yet been no reported case of squamous cell carcinoma induced by laser therapy, it is important for clinicians to recognize both the possibility of laser-induced cancer and the rapid change of cancer, so they can provide appropriate and timely treatment.
Subject(s)
Burns, Chemical/complications , Carcinoma, Squamous Cell/etiology , Laser Therapy/adverse effects , Skin Neoplasms/etiology , Wound Healing/radiation effects , Burns, Chemical/radiotherapy , Carcinoma, Squamous Cell/pathology , Carcinoma, Squamous Cell/surgery , Female , Humans , Middle Aged , Prognosis , Skin Neoplasms/pathology , Skin Neoplasms/surgery , Sodium Hypochlorite/adverse effectsABSTRACT
PURPOSE: To investigate the short-term effects of extremely low frequency pulsed electromagnetic fields (ELF-PEMF) on the healing of alkaline-burned corneas in rabbits. METHODS: Fifty-six alkaline-burned corneas from 56 rabbits were categorized into four groups: ELF-PEMF therapy with 2 mTesla (mT) intensity (ELF 2) for 30 minutes twice daily, ELF-PEMF therapy with 5 mT intensity (ELF 5) for 30 minutes twice daily, medical therapy (MT), and controls. Clinical examination together with digital photography of the corneas was performed on days 0, 2, 7, and 14. After euthanizing the rabbits, affected eyes were evaluated by way of histopathology. Finally the clinical and the histopathologic results of the four groups were compared. RESULTS: None of the cases developed limbal ischemia, symblepharon formation, Descemetocele, or corneal perforation. Although the area of corneal defect in the ELF groups on day 2 was significantly less than the defects in MT, it was not notably different from those on days 7 and 14. Rate of significant corneal neovascularization on days 7 and 14 was not statistically different between the groups. The keratocyte loss in MT was significantly higher than in the ELF groups. Mild stromal scar formation was observed more frequently in ELF-PEMF groups than the control. CONCLUSIONS: Short-term ELF-PEMF therapy is a safe, noninvasive, and markedly effective method in healing alkaline-burned corneas, and its therapeutic results are comparable with those of MT.
Subject(s)
Burns, Chemical/radiotherapy , Corneal Injuries , Electromagnetic Fields , Eye Burns/radiotherapy , Wound Healing/physiology , Alkalies/toxicity , Animals , Burns, Chemical/pathology , Cornea/pathology , Cornea/radiation effects , Disease Models, Animal , Eye Burns/pathology , Female , Rabbits , Radiation Dosage , Treatment OutcomeABSTRACT
Experience in endoscopic examination and treatment of 282 patients with isolated and combined chemical burn of the esophagus (CBE) of different severity is presented. Endoscopic treatment, performed in combination with chemotherapy, consisted in irradiation of burn surface with low-energy laser 'Mustang' through the canal of the endoscope. The procedure was performed 3 times a week up to complete epithelization of burn ulcers. Both in primary esophagogastroduodenoscopy and in repeated examinations sphincter function of the cardia, presence and sizes of axial hiatal hernia, changes of esophageal mucosa and presence of gastroesophageal reflux were analyzed. It is demonstrated that CBE was associated with dysfunction of the cardia in more than 90% cases. Rate of erosive and ulcerous reflux-esophagitis was 24.6-34%; cicatrix stricture of the esophagus - 6.3-12.2% in isolated and combined CBE, respectively. Severity of reflux-esophagitis and its complications was determined by severity of chemical burn.
Subject(s)
Burns, Chemical , Esophagus/injuries , Gastroesophageal Reflux/complications , Adult , Burns, Chemical/complications , Burns, Chemical/drug therapy , Burns, Chemical/physiopathology , Burns, Chemical/radiotherapy , Cicatrix/complications , Endoscopy , Endoscopy, Digestive System , Esophagitis, Peptic , Esophagus/pathology , Esophagus/physiopathology , Female , Follow-Up Studies , Gastroesophageal Reflux/physiopathology , Humans , Laser Therapy , Male , Middle Aged , Time Factors , Wound HealingABSTRACT
Results of conservative measures alone and in combination with local exposure of the burn to laser radiation or clue applications have been compared for 95 patients with chemical burns in the stomach. The combined therapy proved more beneficial as it provided more active healing of the wound, less frequent stenotic complications, shorter hospital stay. Earlier start of local treatment using fiber endoscopy is recommended.
Subject(s)
Burns, Chemical/therapy , Stomach/injuries , Adult , Burns, Chemical/radiotherapy , Burns, Chemical/surgery , Combined Modality Therapy , Constriction, Pathologic , Female , Fiber Optic Technology , Fibrin Tissue Adhesive , Gastroscopy , Humans , Laser Therapy , Male , Wound HealingABSTRACT
Fifty patients with chemical burns of the esophagus were examined fibroesophagoscopically. All of them underwent local endoscopic irradiation by a copper vapour laser. Laser treatment promoted more rapid healing of the esophageal wall. No cicatrization-induced strictures were noted. Adjuvant local laser therapy is believed valid in management of esophageal chemical trauma.
Subject(s)
Burns, Chemical/radiotherapy , Esophageal Stenosis/radiotherapy , Esophagoscopy , Laser Therapy , Adolescent , Adult , Biopsy , Burns, Chemical/diagnosis , Combined Modality Therapy , Esophageal Stenosis/chemically induced , Esophageal Stenosis/diagnosis , Esophagoscopes , Esophagoscopy/methods , Esophagus/pathology , Female , Fiber Optic Technology/instrumentation , Humans , Male , Middle AgedABSTRACT
Overall 240 patients with chemical burns of the esophagus were examined. Local endoscopic treatment with the aid of lasers was applied in 180 victims. The efficacy of different types of laser radiation was compared in terms of the times of the healing of the esophageal wall. It is concluded that further studies should be carried out in the given area.
Subject(s)
Burns, Chemical/radiotherapy , Esophagus/injuries , Laser Therapy , Adolescent , Adult , Aged , Endoscopy , Esophageal Stenosis/chemically induced , Esophageal Stenosis/radiotherapy , Esophagus/radiation effects , Female , Humans , Male , Middle Aged , Radiotherapy DosageSubject(s)
Burns, Chemical/radiotherapy , Caustics/adverse effects , Esophageal Stenosis/radiotherapy , Esophagus/injuries , Laser Therapy , Adolescent , Adult , Aged , Burns, Chemical/complications , Esophageal Stenosis/chemically induced , Esophagoscopes , Esophagus/radiation effects , Female , Fiber Optic Technology , Helium , Humans , Male , Middle Aged , Neon , Radiotherapy Dosage , Wound Healing/physiology , Wound Healing/radiation effectsABSTRACT
Clinical trial of eye films with apilac used in complex treatment of 47 patients with thermic and chemical corneal burns has shown acceleration of corneal epithelialization in 37 (78.7%) patients as compared with the control group. Rise of visual acuity from 0.1-0.4 to 0.5-0.9 was recorded in patients with burns of a moderate degree and from 0.005-0.02 to 0.03-0.07--with severe eye burns. Better results after apilac therapy were observed when the films were used in combination with low-intensity helium-neon laser radiation of the cornea.
