Nabumetone: a clinical appraisal.

Nonsteroidal antiinflammatory drugs (NSAIDs) have long been used as therapy for arthritis patients. However, in some patients these drugs can cause gastrointestinal hemorrhage, perforation, or ulcer through direct topical effects, enterohepatic recirculation, and systemic effects. In an effort to address this problem, new NSAIDs have been developed. Nabumetone, which belongs to a new class of NSAID, is a nonacidic agent that has been associated with a low incidence of peptic ulcer. This article examines available clinical data on nabumetone, including studies on gastrointestinal safety and effectiveness in osteoarthritis and rheumatoid arthritis patients, and data that may provide an explanation for nabumetone's low incidence of ulceration.

[Gas-chromatographic analysis of dichloropinacoline in the air of the work area and water]. / Gazokhromatograficheskoe opredelenie dikhlorpinakolina v vozdukhe rabochei zony i vode.

The article narrates on newly developed techniques for the detection of dichlorpinacolin (DCP) in the working zone air. The study was performed on the chromatograph 'Tsvet 164' equipped with a detector of recombination stability (RCS), using Interton-Super as absorbent with phases SE-30.3% (1), OV-17.3% (II), and Carbowax 1500, 5% (III). The lower threshold for determining DCP in the sample volume was 0.001 mkg, in the air--2.5 mu/m3, and in the water--0.025 m/l. The concentration range in the air: 2.5-40.0 mu/m3 (I,III), 2.5-30 mu/m3 (II); in the water: 0.025-0.4 mu/l (I, III) and 0.025-0.3 mu/l (II). Quantitative assessments were performed through the absolute calibrating technique.