Subject(s)
Calciphylaxis/veterinary , Cat Diseases/diagnosis , Animals , Calcinosis/diagnosis , Calcinosis/pathology , Calcinosis/veterinary , Calciphylaxis/diagnosis , Calciphylaxis/pathology , Cat Diseases/pathology , Cats , Female , Hypercalcemia/diagnosis , Hypercalcemia/pathology , Hypercalcemia/veterinary , Parathyroid Hormone/bloodABSTRACT
BACKGROUND: Calciphylaxis is a rare cutaneous disorder, characterized by vascular calcification and progressive skin necrosis, not yet described in cats. It is scarcely reported in animals, mostly due to iatrogenic or uraemic disturbances of the calcium-phosphate balance. In human patients, it is most commonly seen with end-stage renal disease, but several nonuraemic disorders, including inherited dysfunctions of tissue calcification inhibitors, have also been described. HYPOTHESIS/OBJECTIVES: To describe a case of nonuraemic calciphylaxis in a cat. ANIMALS: A 10-week-old male domestic short hair kitten was presented with hyperacute skin lesions. Initial dermatological signs were characterized by sharp demarcated erosions and ulcerations on the face, including the nasal planum and lips. Cutaneous lesions rapidly progressed into thick crusts with ulcerations, involving parts of the face and pinna as well as abdominal skin. METHODS: Complete blood count, serum chemistry profile, urinalysis, parathyroid hormone measurement and histopathological examination of skin biopsies. RESULTS: Histopathology from newly developed abdominal skin lesions revealed severe epidermal necrosis and calcification, multifocal pannicular calcification and calcified subcutaneous vessels, supporting a diagnosis of calciphylaxis. Treatment consisted of systemic and topical antimicrobials, analgesics, pentoxifylline, Lantharenol(®) , sodium thiosulfate and vitamin K. After initiation of therapy, no further progression was noticed; all medications could be discontinued eventually, and no relapse was seen in the following 2 years. CONCLUSIONS AND CLINICAL IMPORTANCE: Calciphylaxis should be considered as a differential diagnosis for ulcerative cutaneous disorders in young cats. More information on this disease is needed to elucidate the pathomechanism.
Subject(s)
Calciphylaxis/veterinary , Cat Diseases/diagnosis , Animals , Antifibrinolytic Agents/therapeutic use , Calciphylaxis/diagnosis , Calciphylaxis/drug therapy , Calciphylaxis/pathology , Cat Diseases/drug therapy , Cat Diseases/pathology , Cats , Chelating Agents/therapeutic use , Lanthanum/therapeutic use , Male , Thiosulfates/therapeutic use , Vitamin K 1/therapeutic useABSTRACT
Five horses were presented with signs of myopathy along with systemic malaise, hyperfibrinogenemia, hyperphosphatemia, and an elevated calcium phosphorus product (Ca*P). Postmortem findings were consistent with systemic calcinosis, a syndrome of calcium deposition in the tissue of organs including lungs, kidneys, muscle, and heart that has not been previously described in horses.
