1.
J Med Chem
; 21(6): 507-13, 1978 Jun.
Article
in English
| MEDLINE
| ID: mdl-580938
Subject(s)
Antineoplastic Agents/chemical synthesis , Carbanilides/chemical synthesis , Adenocarcinoma/metabolism , Animals , Antineoplastic Agents/pharmacology , Antineoplastic Agents/therapeutic use , Carbanilides/analogs & derivatives , Carbanilides/pharmacology , Carbanilides/therapeutic use , Cells, Cultured , DNA-Directed DNA Polymerase/metabolism , Female , Leukemia L1210/drug therapy , Leukemia L1210/enzymology , Magnetic Resonance Spectroscopy , Mammary Neoplasms, Experimental/metabolism , Mice , Structure-Activity Relationship
2.
Drug Metab Dispos
; 6(1): 38-44, 1978.
Article
in English
| MEDLINE
| ID: mdl-23272
ABSTRACT
The metabolism and excretion of 14C-labeled 3,4,4'-trichlorodiphenylurea has been studied in the rat after oral and iv administration. More than 80% of the administered radioactivity was excreted in the feces and urine over 5 days. Five isolated metabolites were characterized by mass spectrometry and by comparative thin-layer chromatography with synthesized compounds. Metabolites found include 2'-hydroxy-, 3'-hydroxy-, 6-hydroxy-, 2',6-dihydroxy- and 3',6-dihydroxy-3,4,4'-trichlorodiphenylurea.
