ABSTRACT
A 55-year-old woman was admitted for the delayed neuropsychiatric syndrome of carbon monoxide (CO) poisoning (NSCs) from oak burning. Brain MRI showed diffuse high-intensity lesions on T2-weighted images of the left frontal and the occipital lobe. Treatment: The patient received transplantation of umbilical cord blood (UCB) stem cells, combined with injection of nicholine, intranasal inhalation of insulin.Outcomes: On the 24th day of hospitalization, the patient's orientation was improved. The brain MRI on the 75th day showed greatly decreased lesions. On the 86th day, all symptoms were disappeared. Conclusion: This new therapy is promising for the treatment of delayed NSCs.
Subject(s)
Carbon Monoxide Poisoning/therapy , Cord Blood Stem Cell Transplantation , Hypoglycemic Agents/administration & dosage , Insulin/administration & dosage , Neuroprotective Agents/administration & dosage , Neurotoxicity Syndromes/therapy , Administration, Inhalation , Administration, Intranasal , Carbon Monoxide Poisoning/drug therapy , Carbon Monoxide Poisoning/surgery , Combined Modality Therapy , Female , Humans , Middle Aged , Neurotoxicity Syndromes/drug therapy , Neurotoxicity Syndromes/pathology , Neurotoxicity Syndromes/surgery , Time FactorsABSTRACT
No disponible
Subject(s)
Humans , Male , Adult , Hydrocephalus/chemically induced , Hydrocephalus/complications , Hydrocephalus/surgery , Carbon Monoxide Poisoning/complications , Carbon Monoxide Poisoning/surgery , Brain Edema/chemically induced , Brain Edema/complications , Brain Edema/surgery , Hydrocephalus/physiopathology , Hydrocephalus , Carbon Monoxide Poisoning/physiopathology , Carbon Monoxide Poisoning , Indicators of Morbidity and Mortality , Glasgow Coma Scale , Globus Pallidus/pathologyABSTRACT
Heart transplantation is a demonstrated successful and life-saving treatment for an increasing number of patients. The growth of heart transplantation surgery is limited by the relative lack of suitable donors, and the increasing demand has lead to the expansion of acceptance criteria. Patients succumbing to carbon monoxide (CO) poisoning are usually considered not suitable organ donors and they are routinely rejected in many centers. Although organs from CO poisoning donors have been occasionally used, cardiac transplantation in this scenario remains very uncommon. We report the successful heart transplantation from a CO intoxicated donor, who was previously refused by two other transplantation teams. Standard donor evaluation criteria, transplantation techniques and management were used. Limited cases are described in literature. The present case may increase awareness among emergency department physicians, as well as transplantations teams, that patients dying of CO exposure may be acceptable cardiac donors.
