ABSTRACT
A detailed description of the clinical and morphological aspects of a case of carcinoma of the cervix arising from mesonephric duct remnants is presented, and the literature pertaining to these rare tumors is discussed. At the time of initial surgical treatment the tumor was confined to the cervix; however, eventual metastatic dissemination to the bony and soft tissues of the pelvis, the lungs, and the lower vertebral column resulted in the patient's death 8 years later. The tumor appeared refractory to further attempts at treatment with radiation, progestational therapy, and variety of chemotherapeutic agents. The observation of a focal cylindromatous growth pattern, not previously described in tumors of this type, is presented.
Subject(s)
Carcinoma, Adenoid Cystic/pathology , Uterine Cervical Neoplasms/pathology , Carcinoma, Adenoid Cystic/embryology , Cell Nucleus/ultrastructure , Female , Humans , Mesonephros , Middle Aged , Neoplasm Metastasis/pathology , Uterine Cervical Neoplasms/embryologyABSTRACT
The neural crest origin of cells secreting amine and polypeptide hormones (APUD cells) is a unifying concept. The relationship of the classical endocrine system to that of tumor hormone secretion can be explained by the diffuse migration and later neoplasia of these unique cells. This paper describes the APUD cell origins of oat cell carcinoma.
