ABSTRACT
The paper is concerned with the results of fractionated thermal-radiation action on Brown-Pearce tumor in rabbits, sarcoma-37 (C-37) and Lewis carcinoma (LLC) in outbred and hybrid F1 (C57B1/6 x CBA) mice. Rabbit tumors were subjected to hyperthermia on UHF Plot units 4 h after irradiation, and in mice with a water-bath directly before irradiation. The frequency of Brown-Pearce tumor regression was increased as a result of hyperthermia in 4 h. The comparison of the effectiveness of fractionated radiation or thermal-radiation action on murine tumors (2 of 3 fractions for 4 days) indicated different type changes of the value of the coefficient of thermal enhancement of hyperthermia. For C-37 it was decreased with an increase in the number of fractions, for LLC it was increased, probably as a result of reoxygenation and high radiosensitivity of C-37.
Subject(s)
Hyperthermia, Induced , Neoplasms, Experimental/radiotherapy , Animals , Carcinoma, Brown-Pearce/radiotherapy , Combined Modality Therapy , Dose-Response Relationship, Radiation , Female , Male , Mice , Mice, Inbred C57BL , Mice, Inbred CBA , Neoplasm Transplantation , Rabbits , Remission Induction , Time FactorsABSTRACT
The growing tumor in the organism causes the inflammatory, dystrophic and necrotic changes in the liver and stimulates its regeneration. During X-irradiation there is a summation of the tumor and X-ray effects. The rate of the reparative regeneration is sharply inhibited in later stages of the tumor growth, moreover this inhibition is reduced by irradiation. During X-irradiation poliploidization (the appearance of uninuclear poliploid and increase of binuclear hepatocytes) and sharp proliferation of stroma elements but not proliferation of the parenchyma cells predominate in the mechanism of the liver regeneration.
