ABSTRACT
The clinical picture in three cases of Bowenoid papulosis is reported. Histology indicates carcinoma in situ changes and koilocytosis. Evidence points to the role of human Papillomavirus in the etiology of the disease.
Subject(s)
Bowen's Disease/transmission , Carcinoma, Squamous Cell/transmission , Sexually Transmitted Diseases/transmission , Skin Neoplasms/transmission , Adult , Bowen's Disease/pathology , Humans , Male , Middle Aged , Sexually Transmitted Diseases/pathology , Skin Neoplasms/pathologyABSTRACT
Squamous cancer of the cervix depends upon infection by Human Papilloma Virus (HPV), of which there are many strains. Some are more dangerous than others and they appear to compete with each other for "territory". The prospective use of vaccines and antiviral agents for HPV infection could disturb the balance of this ecosystem. This study derives the expressions for the prevalences of the different strains at equilibrium. The important parameters of these expressions are 1) the rate of change of sexual partner, 2) infectiousness on contact, and 3) the rates at which an infectious/immune phase decays to a non-infectious/immune phase, and then towards partial or full susceptibility to re-infection. The responses to changes in these parameters are investigated. Analysis shows that the balance between competing strains is locally and precariously stable; it can survive moderate inter-strain variations of the transmission and decay parameters; but larger differences, whether natural or artificially induced, can result in the rapid elimination of the disadvantaged strain. This might be exploited in a preventive programme. Conversely, if a harmless strain were eliminated, the harmful strains would fill the territorial gap, and the incidence of cervical cancer might increase.
Subject(s)
Carcinoma, Squamous Cell/microbiology , Tumor Virus Infections/microbiology , Uterine Cervical Neoplasms/microbiology , Carcinoma, Squamous Cell/transmission , Computer Simulation , Ecology , Female , Humans , Models, Biological , Papillomaviridae , Tumor Virus Infections/transmission , Uterine Cervical Neoplasms/transmissionABSTRACT
The human papillomavirus causes a variety of genital lesions: condyloma acuminatum, bowenoid papulosis (carcinoma in situ), and squamous cell carcinoma. Only condylomata have been documented to be sexually transmitted. We report clinical and histopathologic evidence of suspected female to male transmission of bowenoid papulosis to the penis from a woman with condylomata acuminata, squamous cell carcinoma in situ, and focally invasive squamous cell carcinoma of the vulva. These findings indicate a need for thorough clinical and histopathologic evaluation of any anogenital lesions resembling condylomata and occurring in sexual partners. Conservative yet thorough destruction of bowenoid papulosis and squamous cell carcinoma in situ appears to be the treatment of choice.
Subject(s)
Carcinoma, Squamous Cell/transmission , Condylomata Acuminata/transmission , Penile Neoplasms/pathology , Tumor Virus Infections/transmission , Vulvar Neoplasms/pathology , Adult , Biopsy , Bowen's Disease/transmission , Carcinoma, Squamous Cell/pathology , Condylomata Acuminata/pathology , Female , Humans , Male , Papillomaviridae , Skin Neoplasms/transmissionABSTRACT
A three-year-old girl presented with perianal bowenoid papulosis that was presumed to be induced by sexual contact. The lesion was treated by biopsy only and regressed over 8 months without further therapy. The importance of this case with respect to the viral cause, venereal transmission, and spontaneous regression is discussed. This case represents the youngest known patient with bowenoid papulosis reported to date.
