ABSTRACT
The etiology of fetal arrhythmias is still unknown. We therefore did a research for immunologic causes: antimyolemmal antibodies (AMLA) in mothers and umbilical cord serum resulting from secondary immunopathogenesis caused by myocarditis of the mother. Is there a correlation between immunological and clinical findings giving a possible explanation for fetal arrhythmias? In 21 cases mothers and umbilical cord serum was investigated for AMLA; 16 with fetal atrial premature beats, 4 with fetal tachycardia and 1 with fetal bradyarrhythmia. From 16 mothers with fetal atrial premature beats had 12 AMLA, from these were in 4 cases in the umbilical cord serum AMLA. In 4 cases of fetal tachycardia we found in 1 case AMLA in mothers and umbilical cord serum. In the other 3 cases accessory pathways have been the cause for tachycardia. From 19 healthy persons were found in 3 cases AMLA in mothers serum, umbilical cord serum was negative.
Subject(s)
Arrhythmias, Cardiac/congenital , Antibodies, Viral/analysis , Arrhythmias, Cardiac/immunology , Autoantibodies/analysis , Bradycardia/congenital , Bradycardia/immunology , Cardiac Complexes, Premature/congenital , Cardiac Complexes, Premature/immunology , Echocardiography , Female , Humans , Infant, Newborn , Myocarditis/immunology , Myocardium/immunology , Pregnancy , Pregnancy Complications, Cardiovascular/immunology , Tachycardia/congenital , Tachycardia/immunology , Tachycardia, Supraventricular/congenital , Tachycardia, Supraventricular/immunology , Ultrasonography, PrenatalABSTRACT
One of the pathogenetic mechanisms of development of acute myocardial infarction are immunologic changes of the humoral type. Indices of circulating immune complexes and A. M. G. immunoglobulins in acute myocardial infarction indicate the extension of involvement of the cardiac muscle, development of severe complications for the diagnosis and prognosis of acute myocardial infarction. An unfavourable sign is significant reduction of the level of circulating immune complexes and immunoglobulins in acute myocardial infarction.
Subject(s)
Antigen-Antibody Complex/blood , Immunoglobulins/blood , Myocardial Infarction/immunology , Aged , Cardiac Complexes, Premature/etiology , Cardiac Complexes, Premature/immunology , Female , Heart Failure/etiology , Heart Failure/immunology , Humans , Male , Middle Aged , Myocardial Infarction/complications , Time FactorsABSTRACT
The clinicoimmunological study revealed immunocompetence dysfunction in 28 patients with idiopathic ventricular arrhythmias resistant to ritmilen. After sodium nucleinate immunomodulation, ritmilen therapy proved to be beneficial in 46.6% of the patients. A positive result was obtained only in the patients who showed the same or close values as in healthy individuals. The comparison has led to the conclusion that idiopathic ventricular arrhythmias are directly related to immune dysfunction and to the recommendation that sodium nucleinate should be used in the multimodality therapy of the arrhythmias.
