Endurance exercise training in older patients with heart failure: results from a randomized, controlled, single-blind trial.

OBJECTIVES: To test the hypothesis that exercise training (ET) improves exercise capacity and other clinical outcomes in older persons with heart failure with reduced ejection fraction (HfrEF). DESIGN: Randomized, controlled, single-blind trial. SETTING: Outpatient cardiac rehabilitation program. PARTICIPANTS: Fifty-nine patients aged 60 and older with HFrEF recruited from hospital records and referring physicians were randomly assigned to a 16-week supervised ET program (n=30) or an attention-control, nonexercise, usual care control group (n=29). INTERVENTION: Sixteen-week supervised ET program of endurance exercise (walking and stationary cycling) three times per week for 30 to 40 minutes at moderate intensity regulated according to heart rate and perceived exertion. MEASUREMENTS: Individuals blinded to group assignment assessed four domains pivotal to HFrEF pathophysiology: exercise performance, left ventricular (LV) function, neuroendocrine activation, and health-related quality of life (QOL). RESULTS: At follow-up, the ET group had significantly greater exercise time and workload than the control group, but there were no significant differences between the groups for the primary outcomes: peak exercise oxygen consumption (VO(2) peak), ventilatory anaerobic threshold (VAT), 6-minute walk distance, QOL, LV volumes, EF, or diastolic filling. Other than serum aldosterone, there were no significant differences after ET in other neuroendocrine measurements. Despite a lack of a group "training" effect, a subset (26%) of individuals increased VO(2) peak by 10% or more and improved other clinical variables as well. CONCLUSION: In older patients with HFrEF, ET failed to produce consistent benefits in any of the four pivotal domains of HF that were examined, although the heterogeneous response of older patients with HFrEF to ET requires further investigation to better determine which patients with HFrEF will respond favorably to ET.

Oxygen pulse is not predictive of stroke volume in heart failure.

AIM: Stroke volume (SV) is the major cardiovascular discriminator between those that are exercise trained versus untrained individuals and healthy individuals versus those with pathologic left ventricular dysfunction. Furthermore, since the increase in oxygen pulse (O(2)P) (O(2)P=VO(2)/HR?oxygen uptake/heart rate) that occurs with exercise is a function of SV and the arterial-venous oxygen difference (a-vO(2)), O(2)P has been demonstrated a reliable indicator of SV for healthy individuals. Although commonly used as a physiological and clinical marker of SV, the validity of O(2)P as an indicator of SV in patients with heart failure has not been investigated. METHODS: Thirty-one (23 men, 8 women) patients (age: 64+/-7.9; ejection fraction: 24+/-7.8) with chronic heart failure had cardiac output measured during steady-state workloads (25 watts and 75% VO(2peak)) upon entry and again at completion of 12 weeks of exercise training. Four patients were excluded due to clinical complications and 3 because of non-compliance; therefore, 24 patients completed the study. RESULTS: The relationships between SV and O2P are: 1) baseline: SV=11.1+4(O2P), SEE=11.8; r(2)=0.39 and 2) study completion: SV=25.1+2.3(O2P), SEE=12.7; r(2)=0.21. While SV did not increase after 25 watts, O2P continued to increase by 17%, respectively. In addition, there were no training effects on SV or O(2)P. As SV increased, O(2)P underpredicted measured SV. CONCLUSIONS: In patients with heart failure and poor left ventricular function, O(2)P is not recommended as a marker of the SV during exercise.

Management of heart failure after cardiac resynchronization therapy: integrating advanced heart failure treatment with optimal device function.

Cardiac resynchronization therapy (CRT) is an established adjunctive treatment for patients with systolic heart failure (HF) and ventricular dyssynchrony. The majority of recipients respond to CRT with improvements in quality of life, New York Heart Association functional class, 6-min walk test, and ventricular function. Management of HF after CRT may include up-titration of neurohormonal blockade and an exercise prescription through cardiac rehabilitation to further improve and sustain clinical outcomes. Diagnostic data provided by the CRT device may help to facilitate and optimize treatment. Initial nonresponder rates remain problematic. We suggest a simple step-by-step management and troubleshooting strategy that integrates device function with advanced HF therapy in patients who do not initially respond to CRT. This algorithm represents a new, comprehensive, collaborative approach between the HF and electrophysiology specialists to further improve and sustain outcomes in the field of CRT.

Factors associated with the level of movement-related everyday activity and quality of life in people with chronic heart failure.

BACKGROUND AND PURPOSE: Cardiac rehabilitation has been shown to be effective in people with chronic heart failure (CHF), particularly in terms of exercise capacity. However, no effects have been found on the level of movement-related everyday activity. Therefore, rehabilitation programs also should focus on enhancing the level of movement-related everyday activity. The aim of this study was to explore factors associated with the level of movement-related everyday activity and with quality of life in people with CHF. SUBJECTS AND METHODS: Measurements of movement-related everyday activity (using an accelerometry-based Activity Monitor), quality of life, and associated factors were performed in 36 people with stable CHF (New York Heart Association classes II and III). RESULTS: Knee flexion and extension torque, and particularly extension torque, were significantly associated with movement-related everyday activity (r = .43-.49, P < .05), whereas nonphysiological factors such as feelings of being disabled were associated with quality of life (r = .37-.77, P < or = .01, P < .05). No relationship was found between movement-related everyday activity and quality of life (r = .20-.22, P > .05). DISCUSSION AND CONCLUSION: The results indicate that knee torque is associated with the level of movement-related everyday activity in people with CHF and that quality of life is mediated by nonphysiological factors.

Motivational interviewing to promote physical activity for people with chronic heart failure.

AIM: This paper reports a study comparing, over a 5-month period, two different methods of increasing physical activity: a traditional exercise programme and one based on motivational interviewing. BACKGROUND: Chronic heart failure is associated with poor quality of life that can be improved by increased physical activity. Patients who are directed to engage in physical activity have a record of low compliance. METHOD: Sixty older aged heart failure patients were randomly assigned to standard care, motivational interviewing or both treatments. The primary outcome was physical activity (kcal/kg/day), with the 6-minute walk test as a secondary outcome. FINDINGS: At entry, no significant differences were observed between the three groups. Following treatment, the 'motivational interviewing' and 'both treatments' groups reported an increase in their level and type of activities, whereas the 'standard care' group did not. All groups significantly increased their 6-minute walk distance. CONCLUSIONS: Motivational interviewing, which incorporates established behaviour change principles and a flexible approach to promotion of activity, increases reported physical activity in older patients with heart failure over a short period. In terms of level and type of activity, this approach gives a better outcome than standard care, and nurses should explore alternative strategies to promote health in this population.

Safety and efficacy of resistance training in patients with chronic heart failure: research-based evidence.

Although a rich body of research exists regarding the safety and efficacy of resistance training, health care providers continue to caution patients with heart failure not to engage in this type of exercise. Research studies utilizing resistance training demonstrate improvements in muscular strength and endurance, New York Heart Association functional class, and quality of life. Despite the hemodynamic changes which occur during resistance exercise, no negative outcomes have been reported. The purpose of this paper is to review the most current research regarding the use of resistance training with heart failure patients to provide assistance to clinicians and enable them to provide education and appropriate recommendations to their patients.

[Efficacy of climate therapy in patients with chronic cardiac failure at a climate-balneological resort]. / Effektivnost' klimatoterapii patsientov c khronicheskoi serdechnoi nedostatochnost'iu na klimatobal'neologicheskom kurorte.

The aim of our study was to estimate clinical effects of spa therapy (ST) at Sochi-Macesta resort in patients with heart failure (HF). Spa therapy was given to 116 patients with HF functional class (FC) 0-II by NYHA classification. It is shown that ST leads to improvement of the patients' clinical status, reduction of HF FC (from 1.32 +/- 0.09 to 0.66 +/- 0.01, p < 0.001), to increased exercise tolerance (p < 0.05) and better 6-minute walk test results (from 460.3 +/- 11.4 m to 511.2 +/- 11.8 m, p < 0.01), higher myocardial coronary reserve, favourable shifts in blood pressure. ST also has a cardiotonic effect and corrects vegetative status, there was also antiatherogenic effect and an increase in blood coagulation potential. The received data allow us to conclude that ST can be an effective tool of medical rehabilitation in patients with initial stages of heart failure.

Exercise based rehabilitation for heart failure.

BACKGROUND: The prevalence of chronic heart failure is increasing, and increases with increasing age. Major symptoms include breathlessness and restricted activities of daily living due to reduced functional capacity, which in turn affects quality of life. Exercise training has been shown to be effective in patients with coronary heart disease and has been proposed as an intervention to improve exercise tolerance in patients with heart failure. OBJECTIVES: To determine the effectiveness of exercise based interventions compared with usual medical care on the mortality, morbidity, exercise capacity and health related quality of life, of patients with heart failure. SEARCH STRATEGY: We searched the Cochrane Controlled Trials Register (The Cochrane Library Issue 2, 2001), MEDLINE (2000 to March 2001), EMBASE (1998 to March 2001), CINAHL (1984 to March 2001) and reference lists of articles. We also sought advice from experts. SELECTION CRITERIA: RCTs of exercise based interventions. The comparison group was usual medical care as defined by the study, or placebo. Adults of all ages with chronic heart failure. Only those studies with criteria for diagnosis of heart failure (based on clinical findings or objective indices) have been included. DATA COLLECTION AND ANALYSIS: Studies were selected, and data were abstracted, independently by two reviewers. Authors were contacted where possible to obtain missing information. MAIN RESULTS: Twenty-nine studies met the inclusion criteria, with 1126 patients randomised. The majority of studies included both patients with primary and secondary heart failure, NYHA class II or III. None of the studies specifically examined the effect of exercise training on mortality and morbidity as most were of short duration. Exercise training significantly increased VO(2) max by (WMD random effects model) 2.16 ml/kg/min (95% CI 2.82 to 1.49), exercise duration increased by 2.38 minutes (95% CI 2.85 to 1.9), work capacity by 15.1 Watts (95% CI 17.7 to 12.6) and distance on the six minute walk by 40.9 metres (95% CI 64.7 to 17.1). Improvements in VO(2) max were greater for training programmes of greater intensity and duration. HRQoL improved in the seven of nine trials that measured this outcome. REVIEWERS' CONCLUSIONS: Exercise training improves exercise capacity and quality of life in patients mild to moderate heart failure in the short term. There is currently no information regarding the effect of exercise training on clinical outcomes. The findings are based on small-scale trials in patients who are unrepresentative of the total population of patients with heart failure. Other groups (more severe patients, the elderly, women) may also benefit. Large-scale pragmatic trials of exercise training of longer duration, recruiting a wider spectrum of patients are needed to address these issues.

Change in circulating cytokines after 2 forms of exercise training in chronic stable heart failure.

BACKGROUND: A proinflammatory state is recognized in chronic heart failure and the degree of immune activation corresponds to disease severity and prognosis. Training is known to improve symptoms in heart failure but less is known about the effects of specific forms of training on the proinflammatory state. METHODS: Forty-six patients with stable chronic heart failure underwent a home-based program of exercise training for 30 minutes a day, 5 days per week over a 6-week period. Twenty-four used a bicycle ergometer and 22 used an electrical muscle stimulator applied to quadriceps and gastrocnemius muscles. Tumour necrosis factor-alpha (TNF-alpha), TNF-alpha soluble receptors 1 and 2, interleukin 6, and C-reactive protein were measured before and after the training period. RESULTS: Significant improvements in markers of exercise performance were seen in both training groups. Soluble TNF-alpha receptor 2 levels decreased after training in the bike group only (2900 +/- 1069 pg/mL to 2625 +/- 821 pg/mL, P =.013). Trends towards a decrease in levels of TNF-alpha and soluble receptor 1 were also seen in the bike group only. No change in circulating inflammatory markers was observed after stimulator training. CONCLUSIONS: Physical training improves exercise capacity for patients with chronic heart failure but degree of attenuation of the proinflammatory response may depend on the mode of training despite similar improvements in exercise capacity.

A randomised study of home-based electrical stimulation of the legs and conventional bicycle exercise training for patients with chronic heart failure.

AIMS: Recent guidelines recommend regular exercise in the management of patients with chronic heart failure (CHF). This study was designed to compare the safety and efficacy of conventional bicycle exercise and functional electrical stimulation (FES) of the legs as forms of home-based exercise training for patients with stable CHF. METHODS AND RESULTS: Forty-six patients (38 male) with stable NYHA Class II/III heart failure underwent a 6-week training programme using either a bicycle ergometer or electrical stimulation of the quadriceps and gastrocnemius muscles. In the bike group, significant increases were seen in 6-min walk (44.6m, 95% confidence interval (CI) 29.3-60.9 m), treadmill exercise time (110 s, 95% CI 72.2-148.0 s), maximum leg strength (5.32 kg, 95% CI 3.18-7.45 kg), and quadriceps fatigue index (0.08, 95% CI 0.04-0.12) following training. In the stimulator group, similar significant increases were seen following training for 6-min walk (40.6m, 95% CI 28.2-53.0m), treadmill exercise time (67 s, 95% CI 11.8-121.8s), maximum leg strength (5.35 kg, 95% CI 1.53-9.17 kg), and quadriceps fatigue index (0.10, 95% CI 0.04-0.17). Peak VO(2)did not change in either group following training, indicating a low-intensity regime. Quality of life scores improved following training when the bicycle and stimulator groups were considered together, but not when considered separately (-0.43, 95% CI -8.13 to -0.56). CONCLUSIONS: FES produces beneficial changes in muscle performance and exercise capacity in patients with CHF. Within this study, the benefits were similar to those observed following bicycle training. FES could be offered to patients with heart failure as an alternative to bicycle training as part of a home-based rehabilitation programme.

[Physical rehabilitation in the complex hospital therapy of patients with chronic low cardiac output]. / Fizicheskaia reabilitatsiia v kompleksnom statsionarnom lechenii bol'nykh s khronicheskoi serdechnoi nedostatochnost'iu.

AIM: To study action of medication in combination with free-choice bicycle exercise on cerebral and peripheral hemodynamics in patients with chronic heart failure (CHF) of functional class II-III. MATERIAL AND METHODS: At admission to hospital and at discharge 100 patients with CHF of NYHA functional class (FC) II-III hospitalized for progression of CHF have undergone clinical examination, Doppler echocardiography and biomicroscopy of conjunctival vessels. The patients were randomized into two groups: group 1 of 60 patients received standard drugs and exercised on bicycle: group 2 of 40 patients received standard drugs only. RESULTS: The patients of group 2 achieved better hemodynamic effect, greater lowering of total peripheral vascular resistance. In patients with CHF FC II cardiac output increased due to improvement of left ventricular systolic function (end-systolic and end-diastolic volumes reduced by 20.3 and 38.7%, respectively, ejection fraction increased by 13.7%); in patients with FC III--due to improvement of diastolic function (end-diastolic volume reduced by 8.3%). Bicycle exercise in combined treatment of FC II CHF provides improvement in perivascular and intravascular components of microcirculation by 46.7 and 24.3%, respectively. In FC III CHF intravascular microcirculation improved by 24.3%. CONCLUSION: Bicycle exercise of patients with CHF of FC II and III used as an adjuvant to standard drugs has an additional positive effect on central hemodynamics and microcirculation.

Benefits of exercise training in the treatment of heart failure: study with a control group.

OBJECTIVE: Exercise training programs have been proposed as adjuncts to treatment of heart failure. The effects of a 3-month-exercise-training-program with 3 exercise sessions per week were assessed in patients with stable systolic chronic heart failure. METHODS: We studied 24 patients with final left ventricle diastolic diameter of 70+/-10mm and left ventricular ejection fraction of 37+/-4%. Mean age was 52+/-16 years. Twelve patients were assigned to an exercise training group (G1), and 12 patients were assigned to a control group (G2). Patients underwent treadmill testing, before and after exercise training, to assess distance walked, heart rate, systolic blood pressure, and double product. RESULTS: In G2 group, before and after 3 months, we observed, respectively distance walked, 623+/-553 and 561+/- 460m (ns); peak heart rate, 142+/-23 and 146+/- 33b/min (ns); systolic blood pressure, 154+/-36 and 164+/-26 mmHg (ns); and double product, 22211+/- 6454 and 24293+/-7373 (ns). In G1 group, before and after exercise, we observed: distance walked, 615+/-394 and 970+/- 537m (p<0.003) peak heart rate, 143+/-24 and 143+/-29b/min (ns); systolic blood pressure, 136+/-33 and 133+/-24 mmHg (ns); and double product, 19907+/- 7323 and 19115+/-5776, respectively. Comparing the groups, a significant difference existed regarding the variation in the double product, and in distance walked. CONCLUSION: Exercise training programs in patients with heart failure can bring about an improvement in physical capacity.