ABSTRACT
We studied the possibility of using anabolic steroid retabolil injections for complex correction of behavioral and immune parameters in rats with genetic predisposition to catalepsy. Subpopulation composition of lymphoid organ and blood cells was compared in rats with genetic predisposition to catalepsy and Wistar rats after retabolil administration. In rats predisposed to catalepsy, retabolil reduced the total content of thymus cells and increased absolute count of CD8 (+) thymocytes. In Wistar rats, retabolil increased the total cell count and the content of CD4 (+) thymocytes, but reduced the number of CD8 (+) cells. Therefore, changes in the subpopulation composition of thymus cells after retabolil administration were opposite in rats with genetic predisposition to catalepsy and Wistar rats. Retabolil injections reduced the severity of catalepsy response in rats with genetic predisposition. However, the time of freezing in Wistar rats significantly increased under these conditions.
Subject(s)
Anabolic Agents/administration & dosage , Catalepsy/genetics , Lymphocytes/enzymology , Nandrolone/analogs & derivatives , Animals , Catalepsy/drug therapy , Catalepsy/immunology , Genetic Predisposition to Disease , Hydro-Lyases/metabolism , Leukocyte Count , Lymphocytes/drug effects , Male , Nandrolone/administration & dosage , Nandrolone Decanoate , Phenotype , Rats , Rats, Wistar , Spleen/drug effects , Spleen/immunology , Succinate Dehydrogenase/metabolismABSTRACT
Inherited predisposition of ASC mice with depressive behavior to catalepsy was accompanied by a significant decrease in the immune response to sheep erythrocytes (compared to parent strains CBA and AKR). The degree of immunosuppression was highest on day 5 after immunization.
Subject(s)
Antidepressive Agents/pharmacology , Catalepsy/immunology , Freezing Reaction, Cataleptic/drug effects , Freezing Reaction, Cataleptic/physiology , Animals , Catalepsy/drug therapy , Catalepsy/genetics , Genetic Predisposition to Disease , Male , Mice , Mice, Inbred AKR , Mice, Inbred CBA , Mice, Inbred Strains , Neuroimmunomodulation , Species SpecificityABSTRACT
Parameters of the immune status of the thymus and spleen in rats with genetic catalepsy were lower compared to those in Wistar rats. Diurnal variations in cell subpopulations of lymphoid organs were different in animals of these strains. Behavioral characteristics and neuroendocrine state in rats with genetic catalepsy were associated with specific changes in the immune system and neuroimmune interactions.
