Subject(s)
Humans , Male , Middle Aged , Cauda Equina/diagnostic imaging , Nerve Compression Syndromes/diagnosis , Nerve Compression Syndromes/drug therapy , Physical Examination , Magnetic Resonance Imaging/methods , Cauda Equina/physiopathology , Low Back Pain/diagnosis , Lumbar Vertebrae , Anti-Inflammatory Agents/therapeutic useABSTRACT
Cauda equina syndrome (CES) is characterized by varying patterns of low back pain, sciatica, lower extremity sensorimotor loss, and bowel and bladder dysfunction. The prognosis for complete recovery of CES is dependent on not only the time before surgical intervention with decompression but also the severity of the nerve damage. Delayed or severe nerve compression impairs the capability of nerve regeneration. Transplantation of neural stem cells (NSCs) may facilitate axon regeneration and functional recovery in a spectrum of neurological disorders. Our study shows that the NSCs derived from early postnatal dorsal root ganglion (DRG) are able to proliferate to form neurospheres and differentiate into O4(+) oligodendrocytes but not glial fibrillary acidic protein (GFAP(+)) astrocytes or ßIII-tubulin(+) neurons in vitro. After intrathecal transplantation into the lumbar spinal canal stenosis animal model, most of the GFP-expressing NSCs were induced to differentiate into oligodendrocytes in vivo. Although the recovery of sensorimotor function was not significantly improved in rats with transplantation therapy, our results implied that subarachnoid microinjection of NSCs may promote axon regeneration of DRG neurons in the cauda equina model after nerve injury.
Subject(s)
Cell Differentiation , Ganglia, Spinal/pathology , Neural Stem Cells/physiology , Oligodendroglia/metabolism , Polyradiculopathy/therapy , Animals , Cauda Equina/pathology , Cauda Equina/physiopathology , Cells, Cultured , Male , Nerve Regeneration , Neural Stem Cells/transplantation , Nociception , Polyradiculopathy/physiopathology , Rats , Rats, Sprague-Dawley , Recovery of Function , Spheroids, Cellular/metabolismABSTRACT
Se comunican dos casos de pacientes con síndrome de silla de montar, posterior a anestesia peridural continua. Uno de ellos es un caso consecutivo de resección transureteral de la próstata (RTU) y el otro consecutivo a RTU papiloma vesical y hernioplastia inguinal. La técnica de anestesia raquídea o peridural continua se ha usado desde hace muchos años. El síndrome de silla de montar se ha comunicado en la literatura como una complicación de la anestesia raquídea. Los casos aquí comunicados posiblemente sean los dos primeros que se informan con este síndrome, utilizándose anestesia peridural continua