Subject(s)
Busulfan/pharmacology , Cell Biology/drug effects , Cell Survival/drug effects , Spermatogenesis/drug effects , Spermatozoa/physiology , Animals , Dose-Response Relationship, Drug , Epithelium/drug effects , Epithelium/physiology , Male , Mice , Seminal Vesicles/drug effects , Seminal Vesicles/physiology , Spermatozoa/drug effects , Time FactorsSubject(s)
Cell Biology/drug effects , Cell Survival/drug effects , Cortisone/pharmacology , Erythrocytes/immunology , Immunoglobulin G , Animals , Body Weight/drug effects , Chromium Radioisotopes , Complement Fixation Tests , Complement System Proteins , Erythrocyte Count , Erythrocytes/drug effects , Guinea Pigs , Hematocrit , Immunologic Deficiency Syndromes/immunology , Kidney/drug effects , Leukocyte Count , Liver/drug effects , Organ Size , Spleen/drug effectsSubject(s)
Cell Biology/drug effects , Cell Survival/drug effects , Doxorubicin/pharmacology , Heart/drug effects , Melanoma , Muscles/drug effects , Sarcoma , Skin/drug effects , Cell Count , Cell Division/drug effects , Cell Line , Culture Techniques , Doxorubicin/therapeutic use , Drug Evaluation, Preclinical/methods , Fibroblasts/drug effects , Humans , Melanoma/drug therapy , Sarcoma/drug therapy , Time FactorsSubject(s)
Cell Biology/drug effects , Cell Survival/drug effects , Leukemia, Lymphoid/drug therapy , Leukemia, Myeloid, Acute/drug therapy , Methotrexate/therapeutic use , Adolescent , Adult , Bone Marrow/drug effects , Bone Marrow Cells , Child , DNA, Neoplasm/biosynthesis , Humans , In Vitro Techniques , Leucovorin/pharmacology , Leukocytes/drug effects , Methotrexate/pharmacology , Purines/pharmacology , Remission, Spontaneous , Thymidine/metabolism , TritiumSubject(s)
Cell Biology/drug effects , Cell Survival/drug effects , Hydrocortisone/pharmacology , Ribosomes/drug effects , Amino Acids/metabolism , Carbon Radioisotopes , Cell Division/drug effects , Cell Fractionation , Cells, Cultured , Fibroblasts , Humans , Protein Biosynthesis , Ribosomes/metabolism , Tritium , Uridine/metabolismSubject(s)
Radiation-Protective Agents , Animals , Cell Biology/drug effects , Chemical Phenomena , Chemistry , Enzymes , Ions , Mice , Neoplasms/therapy , Nucleic Acids , Oxidative Phosphorylation , Radiation-Protective Agents/analysis , Radiation-Protective Agents/pharmacology , Radiation-Sensitizing Agents , RatsSubject(s)
Cell Biology/drug effects , DNA/biosynthesis , Hydroxyurea/pharmacology , Mitosis , Animals , Depression, Chemical , Epithelial Cells , Folic Acid/pharmacology , Intestine, Small/cytology , Isoproterenol/pharmacology , Kidney/drug effects , Liver Regeneration , Lymphoid Tissue/cytology , Male , Mice , Necrosis , Rats , Salivary Glands/drug effects , Thymidine/metabolism , Tongue/cytology , TritiumSubject(s)
Antineoplastic Agents/pharmacology , Cell Biology/drug effects , Female , Humans , Pancreas/drug effects , Polyploidy , Sex ChromatinSubject(s)
Antioxidants/pharmacology , Cell Biology/drug effects , Culture Techniques , Food Additives/pharmacology , Animals , Carbon Isotopes , DNA/biosynthesis , Fats , Female , Haplorhini , Kidney , Leucine/metabolism , Male , Protein Biosynthesis , RNA/biosynthesis , Sex Factors , Thymidine/metabolism , Toluene/pharmacology , Tritium , Uridine/metabolismABSTRACT
Cells grown in suspension culture were incubated with EDTA-disodium salt and shown to have more easily deformable surfaces and raised electrophoretic mobility than controls, following this treatment. The reversibility of these observations by the addition of calcium ions, and other parallel experiments, support the conclusion that, in these cells, calcium is bound to anionic sites at the cell periphery, some of which are located at the cellular electrokinetic surface. These cells should, therefore, exhibit demonstrable calcium-sensitive aggregation, if current theories on the role of calcium in the physiological situation are correct. The fact that no calcium-sensitive aggregation was observed suggests that calcium does not form "bridges" between the adjacent anionic sites on different cells, and does not act directly by its effects on the diffuse electrical double-layer in this situation. An alternative hypothesis is advanced for the role played by calcium in cell adhesion and separation processes.
Subject(s)
Calcium/pharmacology , Cell Biology/drug effects , Edetic Acid/pharmacology , Culture Media , Culture Techniques , Electrophoresis , Humans , Mathematics , Models, Structural , OsteosarcomaABSTRACT
The effects of chloramphenicol and p-fluorophenylalanine (p-FPA) on growth, proportion of motile cells, average rate of motility, and the chemotactic response of a methionine auxotroph of Escherichia coli K-12 were studied. Kinetic studies revealed that the inhibition of chemotaxis by p-FPA can be explained by the effect on growth, proportion of motile cells, and average rate of motility rather than a selective inhibition of chemotaxis per se. The effect of chloramphenicol on chemotaxis could not be explained in terms of these characteristics. It is concluded that low concentrations of chloramphenicol, unlike p-FPA, selectively inhibit chemotaxis.
