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2.
Pediatr Infect Dis J ; 39(7): e147-e149, 2020 07.
Article in English | MEDLINE | ID: mdl-32427645

ABSTRACT

We report the case of a pediatric life-threatening coronavirus disease 2019 who presented as myocarditis with heart failure. Clinicians should be aware of this severe presentation of the disease in children, possibly linked to an exaggerated inflammatory host immune response to severe acute respiratory syndrome coronavirus 2.


Subject(s)
Betacoronavirus/isolation & purification , Coronavirus Infections/physiopathology , Myocarditis/virology , Pneumonia, Viral/physiopathology , COVID-19 , Cellulitis/virology , Child , Coronavirus Infections/diagnostic imaging , Coronavirus Infections/virology , Disease Progression , Humans , Male , Myocarditis/diagnostic imaging , Myocarditis/physiopathology , Pandemics , Pneumonia, Viral/diagnostic imaging , Pneumonia, Viral/virology , Renal Insufficiency/virology , SARS-CoV-2 , Thorax/diagnostic imaging
3.
Pediatr Dermatol ; 36(3): 406-407, 2019 May.
Article in English | MEDLINE | ID: mdl-30859616

ABSTRACT

Herpetic whitlow of the toe is a common infection in an uncommon location, leading it to be frequently misdiagnosed; however, as the virus responds well to conservative management or antivirals alone, proper identification is necessary to prevent unnecessary interventions. We present a case of herpetic whitlow of the toe with an unusually ominous appearance in a previously healthy and otherwise well-appearing child. This case illustrates the spectrum of herpetic whitlow's clinical presentations and enourages consideration of the disease even for atypical location and severity.


Subject(s)
Cellulitis/virology , Foot Dermatoses/virology , Herpes Simplex/diagnosis , Herpesvirus 1, Human , Acyclovir/therapeutic use , Antiviral Agents/therapeutic use , Cellulitis/drug therapy , Cellulitis/pathology , Child, Preschool , Foot Dermatoses/drug therapy , Foot Dermatoses/pathology , Herpes Simplex/drug therapy , Humans , Male , Toes
6.
Ann Plast Surg ; 73(2): 202-4, 2014 Aug.
Article in English | MEDLINE | ID: mdl-25014327

ABSTRACT

Necrotizing fasciitis and necrotizing cellulitis are serious cutaneous complications in varicella patients. Differentiation of necrotizing cellulitis from necrotizing fasciitis can initially be challenging because of indistinct clinical course at the onset of infection and the lack of definitive diagnostic criteria. This paper reports 2 children with necrotizing cellulitis that developed after varicella infection to draw the attention of health care providers to necrotizing cellulitis that showed slower clinical course than necrotizing fasciitis and recovered with conservative treatment approaches without aggressive surgical intervention.


Subject(s)
Cellulitis/diagnosis , Chickenpox/complications , Fasciitis, Necrotizing/diagnosis , Cellulitis/virology , Child, Preschool , Diagnosis, Differential , Fasciitis, Necrotizing/virology , Female , Humans
8.
Pediatr Dermatol ; 29(6): 762-4, 2012.
Article in English | MEDLINE | ID: mdl-22150362

ABSTRACT

Wells' syndrome, otherwise known as eosinophilic cellulitis, is a rare dermatosis seen more commonly in adults than in children. In this article, we present a 5-year-old Caucasian boy who initially presented with pruritic, erythematous macules and papules evolving to bullae formation. Subsequent histology confirmed diagnosis of Wells' syndrome, and additional blood work also demonstrated positive immunoglobulin (Ig)M and IgG for parvovirus. In many instances, the direct etiology of Wells' syndrome is unclear, but the link between parvoviral infection and development of Wells' syndrome could further support an additional cause.


Subject(s)
Cellulitis/pathology , Cellulitis/virology , Eosinophilia/pathology , Eosinophilia/virology , Parvoviridae Infections/pathology , Parvovirus B19, Human/isolation & purification , Antibodies, Viral/blood , Biopsy , Child, Preschool , Humans , Immunoglobulin G/blood , Immunoglobulin M/blood , Male , Parvoviridae Infections/immunology , Parvovirus B19, Human/immunology
10.
Rev Stomatol Chir Maxillofac ; 111(5-6): 334-6, 2010.
Article in French | MEDLINE | ID: mdl-20656312

ABSTRACT

INTRODUCTION: Infectious mononucleosis may lead to numerous complications. Tonsillar hyperplasia with risk of airway obstruction is well known. Dacryocystitis is a rare but potentially severe complication. OBSERVATION: A 6-year-old child with primary mononucleosis infectious diagnosed 8 days before, developed acute dacryocystitis, with rapid evolution to orbital cellulitis, despite adequate antibiotherapy. Emergency surgical drainage was required. DISCUSSION: Dacryocystitis is a rare and little documented complication of EBV infection. Its acute evolution to orbital cellulitis is possible and potentially severe. Its physiopathology is specific. Patients are initially free of chronic stenosis and epiphora, which express acute obstruction of the lachrymal sac due to general lymphoid hyperplasia.


Subject(s)
Dacryocystitis/virology , Infectious Mononucleosis/complications , Acute Disease , Cellulitis/virology , Child , Drainage , Humans , Lacrimal Duct Obstruction/virology , Male , Orbital Diseases/virology
11.
J Endod ; 35(2): 182-8, 2009 Feb.
Article in English | MEDLINE | ID: mdl-19166769

ABSTRACT

Acute apical abscesses and cellulitis are severe endodontic diseases caused by opportunistic bacteria with possible coinfection with latent herpesviruses. The objectives of this study are to identify herpesviruses, including human cytomegalovirus (HCMV), Epstein-Barr virus (EBV), herpes simplex virus-1 (HSV-1), and Varicella zoster virus (VZV) in patients (n = 31) presenting with acute apical abscesses and cellulitis of endodontic origin. Primary and nested polymerase chain reaction (PCR) was conducted using virus-specific primers and DNA isolated from cell-free abscess fluid. From patients exhibiting concurrent spontaneous pain (n = 28), nine abscesses contained HCMV, two abscesses contained EBV, one abscess contained HSV-1, and no abscesses contained VZV. Control PCR using genomic or recombinant templates showed detection limits to a single genomic copy of HCMV, 100 genomic copies for EBV, and 1 to 10 copies for HSV-1 with no cross-amplification between herpesviral DNA targets. Nested PCR was required for detection of herpesviral DNA in the abscess specimens, indicating that these viruses were present in low copy number. Filtration of abscess specimens and virus transfer experiments using human fibroblastic MRC-5 cells confirmed the presence of HCMV particles in several abscess specimens. We conclude that herpesviruses are present but not required for the development of acute apical abscesses and cellulitis of endodontic origin.


Subject(s)
Herpesviridae/pathogenicity , Periapical Diseases/virology , Acute Disease , Adolescent , Adult , Aged , Aged, 80 and over , Alveolar Bone Loss/virology , Cellulitis/virology , Cytomegalovirus/isolation & purification , Cytomegalovirus/pathogenicity , DNA, Viral/analysis , Female , Herpesviridae/genetics , Herpesviridae/isolation & purification , Herpesvirus 1, Human/isolation & purification , Herpesvirus 1, Human/pathogenicity , Herpesvirus 4, Human/isolation & purification , Herpesvirus 4, Human/pathogenicity , Humans , Male , Middle Aged , Periapical Abscess/virology , Polymerase Chain Reaction , Toothache/virology , Virion/isolation & purification , Young Adult
13.
Clin Infect Dis ; 43(6): 737-42, 2006 Sep 15.
Article in English | MEDLINE | ID: mdl-16912948

ABSTRACT

We describe a patient with facial cellulitis/erysipelas due to cowpox virus inoculation in the respiratory epithelium of the nose. A cytopathic agent was isolated in cell culture, and the diagnosis of cowpox was confirmed by electron microscopy and polymerase chain reaction. The most likely source of infection was exposure to the family cats. In addition to the severe edematous cellulitis of the face, the clinical course was dominated by several areas of subcutaneous, necrotizing lymphadenitis, from one of which a huge abscess formed that had to be incised. Hyperbaric oxygen treatment was provided to prevent development of dermal necrosis. The healing process in the numerous areas of lymphadenitis was markedly protracted, and 1 persisting node (which yielded positive results on polymerase chain reaction) had to be excised 2 years after onset of disease. This is the first reported case of inoculation of cowpox virus in the respiratory mucosa of the nose. It resulted in a clinical course totally different than that for inoculation in the skin. We also present a short review of findings on orthopoxvirus infection that focuses on the chain of transmission.


Subject(s)
Cellulitis/virology , Cowpox/diagnosis , Lymphadenitis/virology , Adolescent , Adult , Animals , Cats , Cellulitis/therapy , Child , Cowpox/epidemiology , Cowpox/transmission , Cowpox virus/isolation & purification , Face/pathology , Face/surgery , Female , Humans , Lymphadenitis/therapy , Male , Middle Aged , Respiratory Mucosa/virology
15.
Rev Med Interne ; 24(5): 317-9, 2003 May.
Article in French | MEDLINE | ID: mdl-12763177

ABSTRACT

INTRODUCTION: clinical presentation which seems to be more specific of this infection. EXEGESIS: A 35-year-old woman, 12 weeks pregnant, presented with a primary infection of parvovirus B19. The clinical presentation was characterized by pseudo-cellulitis plaques of the buttocks and the vulva, buccal enanthema with ulcerations and Koplick spot. CONCLUSION: This is the second observation which describes such cutaneous and mucosal manifestations associated with parvovirus B19 infection. This kind of clinical presentation should be systematically reported to become well known by the physicians as erythema infectiosum of fifth disease or "gloves and socks" syndrome.


Subject(s)
Buttocks , Cellulitis/virology , Erythema Infectiosum/pathology , Hand Dermatoses/virology , Oral Ulcer/virology , Parvovirus B19, Human , Pregnancy Complications, Infectious/pathology , Vulva , Adult , Arthralgia/virology , Diagnosis, Differential , Enzyme-Linked Immunosorbent Assay , Erythema Infectiosum/complications , Female , Fever/virology , Humans , Pregnancy , Pregnancy Trimester, First
16.
J Am Acad Dermatol ; 48(5 Suppl): S60-1, 2003 May.
Article in English | MEDLINE | ID: mdl-12734477

ABSTRACT

Eosinophilic cellulitis (Wells' syndrome) is a recurrent inflammatory dermatosis characterized by massive infiltration of eosinophils into the skin. Drugs and pathogens have been recognized causes of eosinophilic cellulitis. We report the repeated association of eosinophilic cellulitis with herpes simplex virus type 2 infections. Antiviral therapy led to a complete remission of eosinophilic cellulitis, indicating that causative treatment of underlying diseases can be effective in controlling eosinophilic cellulitis.


Subject(s)
Cellulitis/etiology , Cellulitis/virology , Herpes Genitalis/complications , Herpesvirus 2, Human/pathogenicity , Antiviral Agents/therapeutic use , Cellulitis/drug therapy , Cellulitis/pathology , Eosinophils , Female , Herpes Genitalis/drug therapy , Herpes Genitalis/pathology , Humans , Middle Aged , Vulva/pathology
17.
Medicina (B Aires) ; 62(6): 572-4, 2002.
Article in Spanish | MEDLINE | ID: mdl-12532693

ABSTRACT

Cutaneous lesions in CMV infection are rare, often a late manifestation of systemic infection, and usually herald a fatal course. A 70 year-old woman received a kidney transplantation one month before consulting and immunosuppressive therapy that included cyclosporine A and methylprednisone. She complained of fever, local pain in her right leg, and an erythematous and swelling plaque. She was treated with intravenous antibiotics without improvement. A skin biopsy was performed and the tissue obtained was sent for bacterial and fungal cultures as well as for histological examination. Cultures were negative. The biopsy showed CMV cytopathic changes. Immunoperoxidase staining was positive for CMV and polymerase chain reaction (PCR) testing revealed CMV DNA. She was treated with ganciclovir with resolution of the lesion. CMV cellulitis is a rare cutaneous manifestation which has not been previously reported.


Subject(s)
Cellulitis/diagnosis , Cytomegalovirus Infections/diagnosis , Aged , Cellulitis/immunology , Cellulitis/virology , Cytomegalovirus Infections/complications , Cytomegalovirus Infections/immunology , Diagnosis, Differential , Female , Humans , Immunocompromised Host , Kidney Transplantation/adverse effects , Kidney Transplantation/immunology
18.
Tidsskr Nor Laegeforen ; 121(8): 956-9, 2001 Mar 20.
Article in Norwegian | MEDLINE | ID: mdl-11332387

ABSTRACT

Chickenpox in childhood is a milder condition than in older patients, but serious and even fatal complications may occur. Complications occur especially in immunosuppressed individuals, but can also be seen in previously healthy children. In Norway, children with varicella and complications have traditionally been hospitalized in departments of medicine. After the new Department of Paediatrics was opened at Ulleval University Hospital in 1998, we have been able to isolate them there. This article describes our experience with these children and discuss our current policy guidelines. We review issues relating to isolation, contagiousness, prevention, complications and treatment, and recommendations from the literature.


Subject(s)
Chickenpox , Cellulitis/pathology , Cellulitis/virology , Chickenpox/complications , Chickenpox/epidemiology , Chickenpox/prevention & control , Chickenpox/transmission , Child , Humans , Norway/epidemiology , Patient Isolation
19.
Scand J Infect Dis ; 30(3): 306-9, 1998.
Article in English | MEDLINE | ID: mdl-9790144

ABSTRACT

Hematogenous osteomyelitis is a known complication of varicella. Osteomyelitis accompanying adjacent soft tissue infection, however, has only been described once in the literature. We report 2 cases of metacarpal osteomyelitis complicating varicella-associated cellulitis of the hand. The cases illustrate that this diagnosis should be considered in a patient with varicella, soft tissue infection and lack of clinical improvement despite apparently appropriate therapy.


Subject(s)
Chickenpox/complications , Hand , Osteomyelitis/etiology , Soft Tissue Infections/complications , Cellulitis/complications , Cellulitis/virology , Child, Preschool , Female , Humans , Male , Metacarpus , Osteomyelitis/diagnosis , Osteomyelitis/virology , Soft Tissue Infections/virology
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