ABSTRACT
Yew leaves poisoning is a rare life-threatening intoxication, whose diagnosis can be difficult. Initial symptoms are nausea, vomiting, abdominal pain, dizziness, tachycardia, muscle weakness, confusion, beginning within 1 hr from ingestion and followed by bradycardia, ventricular arrhythmias, ventricular fibrillation, severe hypotension, and death. Taxine-derived alkaloids are responsible for the toxicity of the yew leaves, blocking sodium and calcium channels, and causing conduction abnormalities. Because of lack of a specific antidote and limited efficacy of common antiarrhythmic drugs, prompt diagnosis, detoxification measures, and immediate hemodynamic support (also with transvenous cardiac stimulation) are essential.
Subject(s)
Arrhythmias, Cardiac/chemically induced , Cephalotaxus/poisoning , Electrocardiography/methods , Heart Arrest/chemically induced , Plant Extracts/poisoning , Plant Leaves/poisoning , Adrenergic alpha-Agonists/therapeutic use , Adult , Aged , Amiodarone/therapeutic use , Anti-Arrhythmia Agents/therapeutic use , Arrhythmias, Cardiac/therapy , Cardiopulmonary Resuscitation , Charcoal/therapeutic use , Female , Gastric Lavage , Heart Arrest/therapy , Humans , Magnesium Sulfate/therapeutic use , Male , Middle Aged , Norepinephrine/therapeutic use , Pacemaker, Artificial , Sodium Bicarbonate/therapeutic use , Treatment OutcomeABSTRACT
No disponible
Subject(s)
Humans , Female , Adult , Cephalotaxus/poisoning , Plant Extracts/toxicity , Suicide, Attempted , Prehospital Care/methods , Gastric LavageSubject(s)
Cephalotaxus/poisoning , Plant Leaves/poisoning , Plant Poisoning/therapy , Adult , Female , HumansABSTRACT
No disponible
Subject(s)
Humans , Male , Adult , Gastric Lavage/methods , Plant Poisoning/therapy , Cephalotaxus/poisoning , Intensive Care Units , Cardiotoxicity/complicationsSubject(s)
Cephalotaxus/poisoning , Electrocardiography , Heart Diseases/chemically induced , Heart Diseases/diagnosis , Plant Poisoning/diagnosis , Suicide, Attempted , Electrocardiography/methods , Female , Heart Diseases/physiopathology , Humans , Plant Leaves/poisoning , Plant Poisoning/physiopathology , Young AdultABSTRACT
No disponible
No disponible
