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[Characteristics of DNA replication of the chromosomes of the bone marrow cells in patients with acute leukemia]. / Osobennosti replikatsii DNK khromosom kletok kostnogo mozga bol'nykh ostrym leikozom

Mamaev, N N; Gerchak, D; Mamaeva, S E; Afanas'ev, B V; Gaponov, G G.

Tsitologiia ; 18(6): 718-24, 1976.

Article in Russian | MEDLINE | ID: mdl-1027161

ABSTRACT

A study of the late DNA replication pattern in chromosomes of human acute leucaemia cells revealed a significant diffrence from control. Chromosomes, 2,3 and 4-5 of the acute leucaemia cells finish their DNA replication earlier, and chromosomes 1, 13-15 and 16 later, compared to the control chromosomes. The difference in the pattern of DNA replication between analogous chromosomes of acute leucaemia and donor cells was associated with the discovery of large late-replicating chromatin blocks in the pericentromeric regions of leucaemia cell chromosomes. Some relationship is suggested between the pattern of pericentromeric heterochromatin DNA replication and cell differentiation.

Subject(s)

Bone Marrow Cells , Bone Marrow/pathology , Chromosomes, Human, 1-3/metabolism , Chromosomes, Human, 13-15/metabolism , Chromosomes, Human, 16-18/metabolism , Chromosomes, Human, 4-5/metabolism , DNA Replication , DNA, Neoplasm/biosynthesis , Leukemia/genetics , Acute Disease , Autoradiography , Cell Differentiation , Humans , Leukemia/pathology , Thymidine , Tritium

[Comparative study of chromosome reproduction in primary culture of embryonic fibroblasts and in leukocyte culture from human peripheral blood]. / Sravnitel'noe izuchenie reproduktsii khromosom v pervichnoi kul'ture émbrional'nykh fibroblastov i v kul'ture leikotsitov perifericheskoi krovi cheloveka.

Slezinger, S I; Amaeva, D M.

Tsitologiia ; 11(4): 415-20, 1969 Apr.

Article in Russian | MEDLINE | ID: mdl-5345805

Subject(s)

Chromosomes , DNA Replication , Fibroblasts/metabolism , Leukocytes/metabolism , Sex Chromosomes/metabolism , Adult , Aged , Autoradiography , Chromosomes, Human, 1-3/metabolism , Chromosomes, Human, 13-15/metabolism , Chromosomes, Human, 16-18/metabolism , Chromosomes, Human, 19-20/metabolism , Chromosomes, Human, 21-22 and Y/metabolism , Chromosomes, Human, 4-5/metabolism , Chromosomes, Human, 6-12 and X/metabolism , Culture Techniques , Female , Humans , Thymidine/metabolism , Tritium

Replication of human chromosomes in primary cultures of embryonic fibroblasts. I. Interchromosomal asychrony on DNA replication.

Slezinger, S I; Prokofieva-Belgovskaya, A A.

Cytogenetics ; 7(5): 337-46, 1968.

Article in English | MEDLINE | ID: mdl-5702320

Subject(s)

Chromosomes/metabolism , DNA Replication , Autoradiography , Chromosomes, Human, 1-3/metabolism , Chromosomes, Human, 16-18/metabolism , Chromosomes, Human, 19-20/metabolism , Chromosomes, Human, 21-22 and Y/metabolism , Chromosomes, Human, 4-5/metabolism , Culture Techniques , Embryo, Mammalian , Fibroblasts/cytology , Fibroblasts/metabolism , Humans , Leukocytes/metabolism , Sex Chromosomes/metabolism , Thymidine/metabolism , Tritium

Replication of human chromosomes in primary cultures of embryonic fibroblasts. II. Intrachromosomal asynchrony of DNA replication.

Prokofieva-Belgovskaya, A A; Slezinger, S I.

Cytogenetics ; 7(5): 347-60, 1968.

Article in English | MEDLINE | ID: mdl-5702321

Subject(s)

Chromosomes/metabolism , DNA Replication , Autoradiography , Chromosomes, Human, 1-3/metabolism , Chromosomes, Human, 13-15/metabolism , Chromosomes, Human, 16-18/metabolism , Chromosomes, Human, 19-20/metabolism , Chromosomes, Human, 21-22 and Y/metabolism , Chromosomes, Human, 4-5/metabolism , Culture Techniques , Fibroblasts/cytology , Humans , Thymidine/metabolism , Tritium

[Studies of the DNA replication pattern of the chromosome groups 4-5, 13-15 and 21-22 in invitro cultured human leukocytes]. / Untersuchungen über die DNA-Replikationmuster der Chromosomengruppen 4-5, 13-15 und 21-22 an in vitro gezüchteten menschlichen Lymphocyten.

Gey, W.

Humangenetik ; 2(3): 246-61, 1966.

Article in German | MEDLINE | ID: mdl-5984968

Subject(s)

DNA Replication , Chromosomes, Human, 13-15/metabolism , Chromosomes, Human, 21-22 and Y/metabolism , Chromosomes, Human, 4-5/metabolism , Female , Humans , In Vitro Techniques , Male , Trisomy

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