ABSTRACT
INTRODUCTION: Ingesting some foods can trigger headache attacks in migraine patients. Diet-sourced citrulline activates the
Subject(s)
Citrullus , Migraine Disorders , Adult , Humans , Young Adult , Arginine , Citrullus/adverse effects , Eating , Headache/etiology , Migraine Disorders/etiology , Nitric Oxide , Nitrites/bloodSubject(s)
Humans , Male , Middle Aged , Food Hypersensitivity/diagnosis , Citrullus/adverse effects , Skin TestsABSTRACT
Background: Food is already recognized as a trigger for migraine, but its mechanism of action has not been fully clarified. There is evidence that they act on the pathogenesis of migraine, interfering with meningeal inflammation, vasodilation and cerebral glucose metabolism.Aim: The aim of this study was to know which plant foods are triggers for migraine and the latency time for the onset of pain.Method: We interviewed patients with migraine and tension-type headache about plant foods that trigger headache and onset time of the headache. We studied 3,935 migraine patients and 1,163 with tension-type headache.Results: There were headaches triggered by plant foods after 90.5 ± 7.9 minutes of ingestion in 40.3% (1,584/3,935) of migraine patients and none with tension-type headache. Headaches triggered by plant foods intake are distributed in the following order of frequency: watermelon (29.5%), passion fruit (3.73%), orange (2.01%), pineapple (1.52%), grape (0.51%), banana (0.46%), cucumber (0.43%), acerola (0.25%) and papaya (0.25%).Conclusions: Many plant foods, especially watermelon, may trigger headache attacks in migraine patients within a few minutes.
Subject(s)
Citrullus/adverse effects , Food/adverse effects , Migraine Disorders/etiology , Tension-Type Headache/etiology , Adolescent , Adult , Aged , Brazil , Female , Humans , Male , Middle Aged , Young AdultSubject(s)
Carotenoids/adverse effects , Citrullus/adverse effects , Citrus paradisi/adverse effects , Hand/pathology , Skin Diseases/pathology , Beta-Cryptoxanthin/blood , Diet Therapy/methods , Economics/statistics & numerical data , Humans , Lycopene/blood , Lycopene/metabolism , Male , Middle Aged , Skin Diseases/diet therapy , Skin Pigmentation/physiology , Treatment OutcomeSubject(s)
Citrullus/adverse effects , Hyperkalemia/etiology , Kidney Failure, Chronic/complications , Potassium, Dietary/adverse effects , Potassium/blood , Aged, 80 and over , Biomarkers/blood , Diet Records , Female , Fruit/adverse effects , Humans , Hyperkalemia/blood , Hyperkalemia/diagnosis , Kidney Failure, Chronic/blood , Kidney Failure, Chronic/diagnosis , Risk Factors , Up-RegulationABSTRACT
Citrullus colocynthis Schrad. is an annual plant that grows in the south, center, and east areas of Iran. It is recognized by different pharmacologic activities in traditional Iranian medicine (TIM) (i.e., purgative, anti-inflammatory, antidiabetic, analgesic, hair growth-promoting, abortifacient, and antiepileptic. Some of these activities were confirmed in modern phytotherapy. Adverse events such as colic, diarrhea, hematochezia, nephrosis, and vomiting and narrow therapeutic index cause herbalists to use this plant cautiously. If some points about this plant in TIM are considered, it may be possible to produce more tolerable preparations from this plant. In this article, all aspects of this plant in TIM are reviewed; also, the medicinal properties declared for this plant in TIM are compared with those showed in modern phytotherapy. In addition, opinions of TIM and modern phytotherapy about safety and acceptable dosage of this plant are discussed.