ABSTRACT
The objective of this study was to evaluate the efficacy and economic efficiency of a systemic treatment of toxic puerperal metritis in dairy cows with ceftiofur. Cows with abnormal vaginal discharge at a postpartum examination (d 4 to 6 after calving) and a rectal temperature > or = 39.5 degrees C were assigned to three treatment groups. Cows in group 1 (n = 70) received 600 mg of ceftiofur intramuscularly (i.m.) on 3 consecutive days. Cows in group 2 (n = 79) received an intrauterine treatment with antibiotic pills consisting of 2500 mg of ampicillin and 2500 mg of cloxacillin and an additional 6000 mg (i.m.) of ampicillin. This treatment was performed on 3 consecutive days. Cows in group 3 (n = 78) received the same intrauterine treatment as in group 2. In addition, 600 mg of ceftiofur was administered i.m. on 3 consecutive days. Body temperature was recorded daily for 6 d after first treatment. There were no significant differences among the groups regarding clinical efficacy at d 6 after first treatment. The cure rates based on rectal temperatures declining to below 39.5 degrees C on d 6 after treatment were 82.9, 84.8, and 84.6% for groups 1, 2, and 3, respectively. Reproductive performance did not differ significantly between group 1 and groups 2 and 3 for any of the measures tested. A financial analysis with 87 different cost scenarios demonstrated that a systemic treatment of toxic puerperal metritis in cattle with ceftiofur is an effective alternative to the combination of local and systemic treatments.
Subject(s)
Anti-Bacterial Agents/therapeutic use , Cattle Diseases/drug therapy , Cephalosporins/therapeutic use , Endometritis/veterinary , Puerperal Disorders/veterinary , Reproduction/drug effects , Ampicillin/economics , Ampicillin/therapeutic use , Animals , Anti-Bacterial Agents/economics , Cattle , Cattle Diseases/economics , Cephalosporins/economics , Cloxacillin/economics , Cloxacillin/therapeutic use , Costs and Cost Analysis , Drug Therapy, Combination , Endometritis/drug therapy , Endometritis/economics , Female , Injections, Intramuscular/veterinary , Puerperal Disorders/drug therapy , Puerperal Disorders/economics , Treatment OutcomeABSTRACT
Se analizan los resultados de un programa experimental de manejo de las infecciones respiratorias agudas de invierno en adultos mayores. Este programa se aplicó por 3 meses entre julio y septiembre de 1997. El material estuvo constituido por 49 pacientes mayores de 65 años (26 hombres y 23 mujeres); con edad promedio de 74,2 años; portadores de neumonías de más de un lóbulo (51 por ciento); con 2,1 factores de riesgo; con puntaje de gravedad de 5,59 y todos con patologías orgánicas previas de base. El tratamiento recomendado fue penicilina (2 millones cada 8 horas), ceftriaxona (1 gramo diario) y eventualmente cloxacilina (500 mg cada 6 horas). La mortalidad (6 mujeres y 4 hombres) fue de 20,4 por ciento. El promedio de días de hospitalización fue de 20,5 días y el de tratamiento antibiótico de 14 días. El costo de los antibióticos fue de 32.618 pesos por paciente y de 2.297 pesos diarios. La hospitalización por enfermo tuvo para el establecimiento un costo promedio de 800.000 pesos, del cual sólo el 5 por ciento corresponde a los antibióticos
