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Scand J Immunol ; 69(5): 457-64, 2009 May.
Article in English | MEDLINE | ID: mdl-19508377

ABSTRACT

Factor H plays a key inhibitory role in control of the activation of alternative pathway of complement system. The aim of the study was to investigate the predictive value of factor H as a biomarker of renal injury in IgA nephropathy (IgAN). Urine factor H concentration from 202 patients was measured and compared with that of 60 healthy volunteers. Forty-eight patients fulfilled Haas-I or II (group 1), 60 fulfilled Haas-III (group 2) and 94 fulfilled Haas-IV or V (group 3). Co-deposition of factor H and C3b in kidneys were investigated using confocal microscope. The levels of urinary factor H, when expressed as a ratio of urinary creatinine, were significantly higher in groups 3 than group 1 and 2, also significantly higher in group 2 than group 1. In addition, the levels of urinary factor H were significantly higher in those with factor H deposition in the kidney than those without deposition. The levels of urinary factor H may be a useful biomarker to evaluate kidney injury in IgAN.


Subject(s)
Complement Factor H/urine , Glomerulonephritis, IGA/diagnosis , Kidney/pathology , Adult , Biomarkers/urine , Complement C3b/metabolism , Complement Factor H/metabolism , Complement Factor H/standards , Creatinine/blood , Creatinine/urine , Enzyme-Linked Immunosorbent Assay , Female , Fluorescent Antibody Technique, Direct , Glomerulonephritis, IGA/classification , Glomerulonephritis, IGA/urine , Humans , Kidney/metabolism , Male , Microscopy, Confocal , Middle Aged , Predictive Value of Tests , Reference Standards , Young Adult
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