[Peripheral blood lymphocyte subpopulations of postmenopausal women with hormone replacement therapy]. / Lymphozytendifferenzierung im peripheren Blut von Frauen unter Hormonsubstitution im Klimakterium.

The effect of hormone replacement therapy on cellular immunity of postmenopausal women was studied by flow cytometry (FACS). Lymphocyte subsets in peripheral blood before and after hormonal replacement therapy (HRT) were measured. After 6 months of HRT with the sequential combined drug Klimonorm(R) (2 mg estradiol valerate and 0,15 mg levonorgestrel) the cytotoxic T-cells (CD8) were reduced and the CD4/CD8 ratio was increased significantly (p < 0,05).