Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/adverse effects , Coronary Stenosis/chemically induced , Ductus Arteriosus/drug effects , Maternal Exposure/adverse effects , Administration, Topical , Adult , Constriction, Pathologic/chemically induced , Constriction, Pathologic/embryology , Coronary Stenosis/embryology , Ductus Arteriosus/embryology , Female , Humans , Live Birth , Medical Illustration , PregnancyABSTRACT
Congenital anomalies of the coronary arteries occur in 0.2-1.2% of the general population; they cause 12% of sports-related sudden cardiac deaths and 1.2% of non-sports-related deaths. We review some of the substantial advances that have been made both, in the understanding of the embryonic development of the coronary arteries and in the clinical diagnosis and management of their anomalies. In this second part of our review we elucidate recent approaches to defining coronary anomalies and provide information on their incidence and prognosis. In addition, we discuss the options for screening large populations for potentially lethal coronary malformations and elucidate the role of invasive diagnostic modalities such as intravascular ultrasound, flow wire and pressure wire. The clinical relevance of coronary anomalies is discussed particularly for the ill-defined group of anomalies that only occasionally cause severe clinical events comprising anomalous origination of a coronary artery from the opposite sinus (ACAOS), coronary artery fistulae and myocardial bridging. Finally, we provide an update on current diagnostic and therapeutic recommendations.
