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1.
Goiânia; SES/GO; 04 jun 2024. 1-16 p. fig, map, quad.(Perfil epidemiológico dos casos de varíola bovina em humanos em Goiás, 25, 4).
Monography in Portuguese | LILACS, CONASS, Coleciona SUS, SES-GO | ID: biblio-1560716

ABSTRACT

A varíola bovina (VB) é uma dermatite zoonótica que feta bovinos, roedores, cães, gatos e humanos, causada pelo vírus da vaccínia (VACV), pertencente ao gênero Orthopxvirus.Este estudo visa estabelecer o perfil epidemiológico da VB em Goiás, com o propósito de orientar profissionais de saúde e trabalhadores rurais sobre a doença e foi desenvolvido baseado no banco de dados do Sistema de Agravos e Notificação (SINAN-NET), do Gerenciador de Ambiente Laboratorial (GAL), dados fornecidos pela Agência Goiana de Defesa Agropecuária (AGRODEFESA) e da Coordenação Estadual de Zoonoses da Gerência de Vigilância Epidemiológica Transmissíveis da Secretaria de Estado da Saúde de Goiás. Tem caráter quantitativo, descritivo e retrospectivo.


Cowpox (BV) is a zoonotic dermatitis that affects cattle, rodents, dogs, cats and humans, caused by the vaccinia virus (VACV), belonging to the genus Orthopxvirus. This study aims to establish the epidemiological profile of BV in Goiás, with the purpose of guiding health professionals and rural workers about the disease and was developed based on the database of the Diseases and Notification System (SINAN-NET), the Laboratory Environment Manager (GAL), data provided by the Goiana Agricultural Defense Agency ( AGRODEFESA) and the State Coordination of Zoonoses of the Transmissible Epidemiological Surveillance Management of the State Department of Health of Goiás. It has a quantitative, descriptive and retrospective nature


Subject(s)
Humans , Infant, Newborn , Infant , Child, Preschool , Child , Adolescent , Adult , Middle Aged , Aged , Aged, 80 and over , Cowpox/epidemiology
2.
J Comp Pathol ; 204: 39-46, 2023 Jul.
Article in English | MEDLINE | ID: mdl-37352825

ABSTRACT

Cowpox virus is considered to be a re-emerging zoonotic pathogen and a public health threat due to increasing numbers of cases in humans and animals in Europe over the past decade, including within the United Kingdom (UK). We present epidemiological data and diagnostic features of 27 recent, naturally occurring cowpox cases in zoo and wild animals across the UK, including the first reports of cowpox in two snow leopards (Panthera uncia), a Bengal tiger (Panthera tigris tigris), three Chilean pudus (Pudu puda), a Malayan tapir (Tapirus indicus) and a Eurasian otter (Lutra lutra), and the first reports of Orthopoxvirus infection in a lar gibbon (Hylobates lar), a Southern tamandua (Tamandua tetradactyla) and an aardvark (Orycteropus afer). This study provides a detailed overview of cowpox infections in a wide range of non-domestic animal species, presents a range of methods for diagnosis and demonstrates the value of retrospective analysis of pathology surveillance in revealing epidemiological links.


Subject(s)
Cowpox , Deer , Otters , Panthera , Tigers , Humans , Animals , Animals, Wild , Cowpox/epidemiology , Cowpox/veterinary , Retrospective Studies , Vermilingua , Cowpox virus , United Kingdom/epidemiology , Animals, Zoo
3.
Biomolecules ; 13(2)2023 02 08.
Article in English | MEDLINE | ID: mdl-36830694

ABSTRACT

Cowpox viruses (CPXVs) exhibit the broadest known host range among the Poxviridae family and have caused lethal outbreaks in various zoo animals and pets across 12 Eurasian countries, as well as an increasing number of human cases. Herein, we review the history of how the cowpox name has evolved since the 1700s up to modern times. Despite early documentation of the different properties of CPXV isolates, only modern genetic analyses and phylogenies have revealed the existence of multiple Orthopoxvirus species that are currently constrained under the CPXV designation. We further chronicle modern outbreaks in zoos, domesticated animals, and humans, and describe animal models of experimental CPXV infections and how these can help shaping CPXV species distinctions. We also describe the pathogenesis of modern CPXV infections in animals and humans, the geographic range of CPXVs, and discuss CPXV-host interactions at the molecular level and their effects on pathogenicity and host range. Finally, we discuss the potential threat of these viruses and the future of CPXV research to provide a comprehensive review of CPXVs.


Subject(s)
Cowpox virus , Cowpox , Animals , Humans , Cowpox virus/genetics , Cowpox/epidemiology , Phylogeny , Disease Outbreaks
4.
Emerg Infect Dis ; 27(10): 2570-2577, 2021 10.
Article in English | MEDLINE | ID: mdl-34352194

ABSTRACT

Cowpox virus (CPXV) has an animal reservoir and is typically transmitted to humans by contact with infected animals. In 2017, CPXV infection of a pregnant woman in France led to the death of her fetus. Fetal death after maternal orthopoxvirus (smallpox) vaccination has been reported; however, this patient had not been vaccinated. Investigation of the patient's domestic animals failed to demonstrate prevalence of CPXV infection among them. The patient's diagnosis was confirmed by identifying CPXV DNA in all fetal and maternal biopsy samples and infectious CPXV in biopsy but not plasma samples. This case of fetal death highlights the risk for complications of orthopoxvirus infection during pregnancy. Among orthopoxviruses, fetal infection has been reported for variola virus and vaccinia virus; our findings suggest that CPXV poses the same threats for infection complications as vaccinia virus.


Subject(s)
Cowpox , Orthopoxvirus , Animals , Cowpox/diagnosis , Cowpox/epidemiology , Cowpox/veterinary , Cowpox virus/genetics , Female , Fetal Death , Fetus , France/epidemiology , Humans , Young Adult
5.
Vector Borne Zoonotic Dis ; 20(6): 471-475, 2020 06.
Article in English | MEDLINE | ID: mdl-32013767

ABSTRACT

Cowpox virus (CPXV), genus Orthopoxvirus, family Poxviridae, is a zoonotic pathogen in Eurasian wild rodents. High seroprevalences have been reported previously for vole and murine species in Europe. In contrast, viral DNA was only rarely detected, and very few reservoir-derived CPXV isolates exist. In this study, CPXV DNA and CPXV-reactive antibodies were monitored in wild small mammals for 5 years in four German federal states. Screening of liver tissues of 3966 animals by CPXV real-time PCR (qPCR) revealed five voles of two species positive for CPXV DNA. Two positive bank voles (Myodes glareolus) and two positive common voles (Microtus arvalis) originated from two plots in Baden-Wuerttemberg. One positive bank vole originated from Mecklenburg-Western Pomerania. None of the small mammals from Thuringia and North Rhine-Westphalia was positive in the qPCR. CPXV antigen-based indirect immunofluorescence assays of 654 highly diluted chest cavity fluid samples detected two bank voles and two common voles from the same sites in Baden-Wuerttemberg to be highly seroreactive. Five animals were CPXV DNA positive, and four other animals were orthopoxvirus seropositive. Our study indicates both a very low prevalence and a patchy occurrence of CPXV in common and bank voles and absence in other rodent and shrew species in Germany. The multiple detection of infected voles at one site in Baden-Wuerttemberg and continued detection in a region of Mecklenburg-Western Pomerania classify these regions as potential endemic foci.


Subject(s)
Arvicolinae/virology , Cowpox virus/isolation & purification , Cowpox/veterinary , Disease Reservoirs/veterinary , Rodent Diseases/virology , Animal Distribution , Animals , Cowpox/epidemiology , Cowpox/virology , Ecosystem , Germany/epidemiology , Humans , Liver/virology , Rodent Diseases/epidemiology
6.
Article in German | MEDLINE | ID: mdl-29536472

ABSTRACT

Cowpox virus (CPXV) infection is a reportable and potentially zoonotic disease that occurs sporadically in a variety of animals. During the past six decades, CPXV infection has been extensively researched and described in both domestic (cat, dog, horse, cattle) and zoo animals (e. g. elephant, rhinoceros, okapi). Of note, a review of the literature produced only three reports of CPXV in individual or small groups of South American camelids. The goal of this review was to describe the current knowledge as it relates to clinical features of CPXV infection in South American camelids and to compare the clinical manifestations with those described in other animal species. In alpacas and llamas, virus transmission occurs via direct contact with infected animals or oronasal infection through microlesions in the skin and mucous membranes. In its mild form, the disease is limited to certain regions of the body (head, neck, extremities or perineal region) and characterised by pustules or crusts. CPXV infection can also cause generalised and frequently lethal disease with multifocal to diffuse skin lesions (papules, pustules, crusts, ulcers) accompanied by virus replication in other organs. Conjunctivitis, stomatitis and rhinitis are seen commonly together with nonspecific clinical signs, including anorexia, listlessness and fever. As in other poxvirus infections, factors leading to an immunosuppression may contribute to the development of the clinical ma -nifestation of CPXV infection. There appear to be no specific manifestations of CPXV infection in South American camelids. More research is needed to fully understand the pathogenesis and epidemio logy of CPXV infection, particularly in South American camelids.


Subject(s)
Camelids, New World/virology , Cowpox virus/isolation & purification , Cowpox/veterinary , Animals , Cowpox/diagnosis , Cowpox/epidemiology , Cowpox/virology , Skin/pathology , Skin/virology , South America
7.
Viruses ; 9(11)2017 11 18.
Article in English | MEDLINE | ID: mdl-29156539

ABSTRACT

Four cowpox virus (CPXV) outbreaks occurred in unrelated alpaca herds in Eastern Germany during 2012-2017. All incidents were initially noticed due to severe, generalized, and finally lethal CPXV infections, which were confirmed by testing of tissue and serum samples. As CPXV-infection has been described in South American camelids (SACs) only three times, all four herds were investigated to gain a deeper understanding of CPXV epidemiology in alpacas. The different herds were investigated twice, and various samples (serum, swab samples, and crusts of suspicious pox lesions, feces) were taken to identify additionally infected animals. Serum was used to detect CPXV-specific antibodies by performing an indirect immunofluorescence assay (iIFA); swab samples, crusts, and feces were used for detection of CPXV-specific DNA in a real-time PCR. In total, 28 out of 107 animals could be identified as affected by CPXV, by iIFA and/or PCR. Herd seroprevalence ranged from 16.1% to 81.2%. To investigate the potential source of infection, wild small mammals were trapped around all alpaca herds. In two herds, CPXV-specific antibodies were found in the local rodent population. In the third herd, CPXV could be isolated from a common vole (Microtus arvalis) found drowned in a water bucket used to water the alpacas. Full genome sequencing and comparison with the genome of a CPXV from an alpaca from the same herd reveal 99.997% identity, providing further evidence that the common vole is a reservoir host and infection source of CPXV. Only in the remaining fourth herd, none of the trapped rodents were found to be CPXV-infected. Rodents, as ubiquitous reservoir hosts, in combination with increasingly popular alpacas, as susceptible species, suggest an enhanced risk of future zoonotic infections.


Subject(s)
Camelids, New World/virology , Cowpox/epidemiology , Disease Outbreaks , Zoonoses/epidemiology , Animals , Antibodies, Viral/blood , Arvicolinae/virology , Cowpox/immunology , Cowpox/virology , Cowpox virus/genetics , Cowpox virus/immunology , Cowpox virus/physiology , Disease Reservoirs/virology , Germany/epidemiology , Phylogeny , Polymerase Chain Reaction , Seroepidemiologic Studies , Zoonoses/immunology , Zoonoses/virology
8.
PLoS One ; 12(11): e0187089, 2017.
Article in English | MEDLINE | ID: mdl-29121668

ABSTRACT

Cowpox virus infections in captive cheetahs (Acinonyx jubatus) with high morbidity and mortality have already been reported in the UK and Russia in the 1970s. However, most of the reported cases have been singular events. Here, we report a total of five cowpox virus outbreaks in cheetahs in the same safari park in Denmark between 2010 and 2014. Nine cheetahs showed varying severity of clinical disease; two of them died (22%). All episodes occurred between August and October of the respective year. No other carnivores kept at the same institution nor the keepers taking care of the animals were clinically affected. The clinical picture of cowpox was confirmed by extensive laboratory investigations including histopathological and molecular analyses as well as cell culture isolation of a cowpox virus. High anti-orthopoxvirus antibody titers were detected in all 9 diseased cheetahs compared to seven contact cheetahs without clinical signs and 13 cheetahs not in direct contact. Additionally, whole genome sequencing from one sample of each cluster with subsequent phylogenetic analysis showed that the viruses from different outbreaks have individual sequences but clearly form a clade distinct from other cowpox viruses. However, the intra-clade distances are still larger than those usually observed within clades of one event. These findings indicate multiple and separate introductions of cowpox virus, probably from wild rodent populations, where the virus keeps circulating naturally and is only sporadically introduced into the cheetahs. Sero-positivity of voles (Arvicola amphibious) caught in zoo grounds strengthens this hypothesis. As a consequence, recommendations are given for medical and physical management of diseased cheetahs, for hygienic measures as well as for pre-shipment isolation before cheetah export from zoo grounds.


Subject(s)
Acinonyx/virology , Cowpox virus/physiology , Cowpox/epidemiology , Cowpox/veterinary , Disease Outbreaks/statistics & numerical data , Seasons , Animals , Animals, Zoo/virology , Antibodies, Viral/immunology , Cowpox/immunology , Cowpox/virology , Cowpox virus/immunology , Denmark/epidemiology , Phylogeny , Real-Time Polymerase Chain Reaction
10.
Vopr Virusol ; 61(5): 200-4, 2016.
Article in English | MEDLINE | ID: mdl-29323851

ABSTRACT

Buffalopox is a contagious viral disease affecting milch buffaloes (Bubalus Bubalis) and, rarely, cows. The disease has zoonotic implications, as outbreaks are frequently associated with human infections, particularly in the milkers. Buffalopox is associated with high morbidity (80%). The clinical symptoms of the disease are characterized by wartline lesions on the udder, teats, inguinal region, base of the ears, and over the parotid. In the severe form, generalized rash is observed. Although the disease does not lead to high mortality, it has an adverse effect on the productivity and working capacity of the animals resulting in large economic losses. The outbreaks of buffalopox occurred frequently in India, Pakistan, Bangladesh, Nepal, Iran, Egypt, and Indonesia, where buffaloes are reared as milch animals. The buffalopox is closely related with other Orthopoxviruses. In particular, it is close to the vaccinia virus. There is a view that the buffalopox virus might be derived from the vaccinia virus. It is possible that it became pathogenic to humans and animals through adaptive evolution of the genome by obtaining the virulence genes. PCR is performed for the C18L gene for the purpose of specific detection and differentiation of the buffalopox virus from other orthopoxviruses. The C18L gene encodes the ankyrin repeat protein, which determines the virus host range. The open reading frame of this gene is only 150-nucleotide long as against 453 nucleotide in the vaccinia virus, 756 - in the camelpox virus, and 759 - in the cowpox virus. It can be concluded that a systematic study based on the epidemiology of the virus, existence of reservoirs, biological transmission, and the molecular organization of the buffalopox virus from buffalo, cow, and humans may pave the way to a better understanding of the circulating virus and contribute to the control of the disease using the suitable diagnostic and prophylactic measures.


Subject(s)
Cowpox virus/genetics , Cowpox/epidemiology , Disease Outbreaks , Vaccinia virus/genetics , Vaccinia/veterinary , Zoonoses/epidemiology , Animals , Ankyrin Repeat , Asia, Western/epidemiology , Buffaloes/virology , Cattle , Cowpox/transmission , Cowpox/virology , Cowpox virus/classification , Cowpox virus/isolation & purification , DNA, Viral/genetics , Middle East/epidemiology , Phylogeny , Vaccinia/epidemiology , Vaccinia/transmission , Vaccinia/virology , Vaccinia virus/classification , Vaccinia virus/isolation & purification , Viral Proteins/genetics , Zoonoses/transmission , Zoonoses/virology
12.
Viruses ; 7(3): 1218-37, 2015 Mar 16.
Article in English | MEDLINE | ID: mdl-25785515

ABSTRACT

Vaccinia virus (VACV) has had an important role for humanity because of its use during the smallpox eradication campaign. VACV is the etiologic agent of the bovine vaccinia (BV), an emerging zoonosis that has been associated with economic, social, veterinary and public health problems, mainly in Brazil and India. Despite the current and historical VACV importance, there is little information about its circulation, prevalence, origins and maintenance in the environment, natural reservoirs and diversity. Brazilian VACV (VACV-BR) are grouped into at least two groups based on genetic and biological diversity: group 1 (G1) and group 2 (G2). In this study, we went to the field and investigated VACV clonal diversity directly from exanthemous lesions, during BV outbreaks. Our results demonstrate that the G1 VACV-BR were more frequently isolated. Furthermore, we were able to co-detect the two variants (G1 and G2) in the same sample. Molecular and biological analysis corroborated previous reports and confirmed the co-circulation of two VACV-BR lineages. The detected G2 clones presented exclusive genetic and biological markers, distinct to reference isolates, including VACV-Western Reserve. Two clones presented a mosaic profile, with both G1 and G2 features based on the molecular analysis of A56R, A26L and C23L genes. Indeed, some SNPs and INDELs in A56R nucleotide sequences were observed among clones of the same virus population, maybe as a result of an increased mutation rate in a mixed population. These results provide information about the diversity profile in VACV populations, highlighting its importance to VACV evolution and maintenance in the environment.


Subject(s)
Cowpox/virology , Genetic Variation , Vaccinia virus/classification , Vaccinia virus/genetics , Animals , Body Weight , Brazil/epidemiology , Cattle , Cowpox/epidemiology , Cowpox/pathology , Disease Models, Animal , Genotype , Male , Mice, Inbred BALB C , Molecular Epidemiology , Molecular Sequence Data , Sequence Analysis, DNA , Sequence Homology , Vaccinia virus/isolation & purification , Virulence
13.
Vector Borne Zoonotic Dis ; 14(4): 303-5, 2014 Apr.
Article in English | MEDLINE | ID: mdl-24689730

ABSTRACT

Cowpox virus (CPXV) was isolated from a fatal outbreak among cotton-top tamarins. Samples from healthy common marmosets in contact were also CPXV genome positive. The CPXV isolated from the cotton-top tamarins exhibited a unique hemagglutinin sequence. Pathogenicity investigations using a Wistar rat model characterized the isolate as low pathogenic.


Subject(s)
Cowpox virus/isolation & purification , Cowpox/veterinary , Disease Outbreaks/veterinary , Monkey Diseases/epidemiology , Saguinus/virology , Animals , Cowpox/epidemiology , Cowpox/virology , Cowpox virus/genetics , Cowpox virus/pathogenicity , Disease Models, Animal , Female , Germany/epidemiology , Hemagglutinins, Viral/genetics , Male , Monkey Diseases/virology , Phylogeny , Rats , Rats, Wistar , Sequence Analysis, DNA/veterinary
14.
Emerg Infect Dis ; 19(12): 1996-9, 2013 Dec.
Article in English | MEDLINE | ID: mdl-24274113

ABSTRACT

We investigated 4 related human cases of cowpox virus infection reported in France during 2011. Three patients were infected by the same strain, probably transmitted by imported pet rats, and the fourth patient was infected by another strain. The 2 strains were genetically related to viruses previously isolated from humans with cowpox infection in Europe.


Subject(s)
Cowpox virus/classification , Cowpox virus/genetics , Cowpox/epidemiology , Adult , Animals , Cell Line , Child , Cowpox/transmission , Cowpox virus/isolation & purification , Female , France/epidemiology , Genome, Viral , Humans , Male , Molecular Sequence Data , Phylogeny , Rats
16.
Berl Munch Tierarztl Wochenschr ; 126(1-2): 55-61, 2013.
Article in English | MEDLINE | ID: mdl-23367669

ABSTRACT

Clinical and epidemiological aspects of cats with cowpox in Germany from the years 2004 to 2010 are described and discussed. Questionnaires were sent to veterinarians and owners of affected cats identified with the help of a number of pathology laboratories. Of 69 mailed questionnaires, 45 veterinary and 26 owner questionnaires were returned and a total of 46 feline poxcases were evaluated. The cases were distributed all over Germany although there was an accumulation of cases in specific geographic areas. The clinical and epidemiological observations match those of other studies. The majority of cats were outdoor cats, came from a rural environment and developed clinical signs in late summer or autumn. All cats showed skin lesions which were predominantly localized on the anterior part of the body, 61% of the cats showed other clinical signs in addition to the skin lesions. Approximately half of the cats lived in a multi-pet household, but in only one case clinical signs typical for cowpox were observed in another cat of the household. In two cases a cat-to-human transmission was assumed. In addition, to evaluate the prevalence of pox virus infections in outdoor cats in areas with previous reports of such infections, 92 apparently unaffected outdoor cats were tested for orthopoxvirus antibodies using an indirect immunofluorescence assay. Sixteen (17%) of the tested serum samples were seropositive against orthopoxvirus (titre between 1:20 and 1:40).This is a higher serum prevalence than in previously published studies from Germany. A possible explanation is selection of a population of outdoor cats from regions with previous known clinical cases.


Subject(s)
Cat Diseases/epidemiology , Cowpox/veterinary , Animals , Cat Diseases/diagnosis , Cat Diseases/drug therapy , Cats , Cowpox/diagnosis , Cowpox/drug therapy , Cowpox/epidemiology , Cowpox virus , Germany/epidemiology , Surveys and Questionnaires
17.
Article in Russian | MEDLINE | ID: mdl-22830284

ABSTRACT

Features of spread of cowpox in the contemporary conditions are examined. A decrease of population immunity to pox in the population of Russia caused by cancellation of pox immunization, hidden circulation of cowpox virus in various species of rodents, as well as lack of vigilance to pathogenic orthopoxviurses in healthcare workers were noted to create the real preconditions for the emergence of infection of humans caused by cowpox virus. Thereby presence of means of express laboratory diagnostics of cowpox and means of effective medical protection for the prevention of development of this disease in the population of Russia becomes an actual necessity.


Subject(s)
Cattle Diseases/transmission , Cowpox/epidemiology , Cowpox/veterinary , Disease Reservoirs/veterinary , Zoonoses/transmission , Animals , Cattle , Cattle Diseases/epidemiology , Cattle Diseases/virology , Cowpox/transmission , Cowpox/virology , Cowpox virus/physiology , Disease Reservoirs/virology , Humans , Immunization/statistics & numerical data , Rodentia , Russia/epidemiology , Zoonoses/epidemiology , Zoonoses/virology
18.
J Infect Dis ; 206(1): 63-8, 2012 Jul 01.
Article in English | MEDLINE | ID: mdl-22539811

ABSTRACT

BACKGROUND: Cowpox virus is an Orthopoxvirus that can cause infections in humans and a variety of animals. Infections occur in Eurasia; infections in humans and animals have not been reported in the United States. This report describes the occurrence of the first known human case of laboratory-acquired cowpox virus infection in the United States and the ensuing investigation. METHODS: The patient and laboratory personnel were interviewed, and laboratory activities were reviewed. Real-time polymerase chain reaction (PCR) and serologic assays were used to test the patient's specimens. PCR assays were used to test specimens obtained during the investigation. RESULTS: A specimen from the patient's lesion tested positive for cowpox virus DNA. Genome sequencing revealed a recombinant region consistent with a strain of cowpox virus stored in the research laboratory's freezer. Cowpox virus contamination was detected in 6 additional laboratory stocks of viruses. Orthopoxvirus DNA was present in 3 of 20 environmental swabs taken from laboratory surfaces. CONCLUSIONS: The handling of contaminated reagents or contact with contaminated surfaces was likely the mode of transmission. Delays in recognition and diagnosis of this infection in a laboratory researcher underscore the importance of a thorough patient history-including occupational information-and laboratory testing in facilitating a prompt investigation and application of control and remediation measures.


Subject(s)
Cowpox virus/isolation & purification , Cowpox/virology , DNA, Viral/isolation & purification , Infectious Disease Transmission, Patient-to-Professional , Laboratory Infection/virology , Laboratory Personnel , Cowpox/epidemiology , Cowpox/transmission , Cowpox virus/genetics , DNA Contamination , DNA, Viral/genetics , Humans , Laboratory Infection/epidemiology , Laboratory Infection/transmission , United States/epidemiology
19.
Acta Derm Venereol ; 92(2): 126-31, 2012 Mar.
Article in English | MEDLINE | ID: mdl-22041995

ABSTRACT

Cowpox virus infection of humans is an uncommon, potentially fatal, skin disease. It is largely confined to Europe, but is not found in Eire, or in the USA, Australasia, or the Middle or Far East. Patients having contact with infected cows, cats, or small rodents sporadically contract the disease from these animals. We report here clinical aspects of 8 patients from the Munich area who had purchased infected pet rats from a local supplier. Pet rats are a novel potential source of local outbreaks. The morphologically distinctive skin lesions are mostly restricted to the patients' necks, reflecting the infected animals' contact pattern. Individual lesions vaguely resemble orf or Milker's nodule, but show marked surrounding erythema, firm induration and local adenopathy. Older lesions develop eschar, leaving slow-healing, deep ulcerative defects after eschar separation. Severe flu-like illness may be present in the acute phase. Smallpox-vaccinated patients tend to develop less severe reactions and heal more quickly. The differential diagnosis may include other localized orthopoxvirus infections, herpes simplex, bacterial infection, anthrax, foreign body granuloma, and primary tuberculosis. Dermatologists should be aware of the diagnostic and therapeutic algorithms for handling this disease.


Subject(s)
Cowpox virus , Cowpox/epidemiology , Cowpox/transmission , Disease Outbreaks , Pets/virology , Skin Diseases, Viral/transmission , Adolescent , Adult , Animals , Cowpox/diagnosis , Cowpox/veterinary , Female , Germany/epidemiology , Humans , Male , Middle Aged , Rats , Skin Diseases, Viral/diagnosis , Skin Diseases, Viral/epidemiology , Skin Diseases, Viral/veterinary , Young Adult
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