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1.
Eur J Neurol ; 31(7): e16301, 2024 Jul.
Article in English | MEDLINE | ID: mdl-38628041

ABSTRACT

BACKGROUND AND PURPOSE: Cryopyrin-associated periodic syndrome is a rare autoinflammatory disease caused by gain-of-function mutations or variants in the NLRP3 gene. Clinically, patients suffer from a broad spectrum of both systemic and neurological symptoms. The aim of this study was to determine whether systemic inflammation demonstrated by serum amyloid A (SAA) elevation is associated with neuroinflammation assessed by optical coherence tomography (OCT). METHODS: Thirty eyes of 15 patients with NLRP3 low penetrance mutations (PwNLRP3) and 20 eyes of 10 age- and sex-matched healthy controls were examined by spectral-domain OCT as part of routine clinical care. All retinal layers and clinical features were evaluated. RESULTS: At baseline no significant retinal neuroaxonal inflammation or degeneration was observed in all measured retinal layers amongst PwNLRP3 compared with healthy controls. In a pooled analysis of all individual OCT time points a significant difference regarding the macular retinal nerve fibre layer was detected. Increased levels of SAA showed a positive association with averaged combined outer plexiform layer and outer nuclear layer volumes (ρ < 0.0001, r2 = 0.35). CONCLUSION: In cryopyrin-associated periodic syndrome increased combined outer plexiform layer and outer nuclear layer volumes are mirrored by SAA increase, an acute phase reactant indicating systemic inflammation. Our findings identify OCT as a candidate biomarker to monitor subclinical neuroinflammation and to assess disease activity in PwNLRP3.


Subject(s)
Cryopyrin-Associated Periodic Syndromes , NLR Family, Pyrin Domain-Containing 3 Protein , Tomography, Optical Coherence , Humans , Male , Female , Cryopyrin-Associated Periodic Syndromes/diagnostic imaging , Cryopyrin-Associated Periodic Syndromes/genetics , Adult , NLR Family, Pyrin Domain-Containing 3 Protein/genetics , Adolescent , Young Adult , Child , Middle Aged , Serum Amyloid A Protein/metabolism , Retina/diagnostic imaging , Retina/pathology
2.
Neuroradiol J ; 32(6): 420-425, 2019 Dec.
Article in English | MEDLINE | ID: mdl-31337256

ABSTRACT

Cryopyrin-associated periodic syndrome is a hereditary inflammatory disorder encompassing a wide spectrum of clinical phenotypes. This disorder has been associated with mutation of the NLRP3 gene coding for cryopyrin, which leads to overproduction of interleukin-1. The condition causes relapsing bouts of inflammation involving multiple organ systems, including the central nervous system, and, if untreated, can lead to long-term debilitating effects. A literature review revealed only a few brief descriptions of magnetic resonance imaging findings in cryopyrin-associated periodic syndrome patients. We describe serial magnetic resonance imaging findings in an 11-year-old female with clinically diagnosed cryopyrin-associated periodic syndrome who presented with intermittent headaches, progressive sensorineural hearing loss, fevers, and abdominal pain. The magnetic resonance imaging showed progressively worsening low T2 signal in the cochlea, cochlear enhancement, and leptomeningeal enhancement. We also describe some previously unreported findings in this syndrome, including cranial nerve and cauda equina enhancement.


Subject(s)
Cauda Equina/diagnostic imaging , Central Nervous System/diagnostic imaging , Cochlea/diagnostic imaging , Cranial Nerves/diagnostic imaging , Cryopyrin-Associated Periodic Syndromes/diagnostic imaging , Arnold-Chiari Malformation/complications , Arnold-Chiari Malformation/diagnostic imaging , Brain/diagnostic imaging , Child , Cryopyrin-Associated Periodic Syndromes/complications , Disease Progression , Female , Hearing Loss, Sensorineural/complications , Hearing Loss, Sensorineural/diagnostic imaging , Humans , Magnetic Resonance Imaging , Meninges/diagnostic imaging , Spinal Cord/diagnostic imaging
3.
J Rheumatol ; 44(11): 1667-1673, 2017 Nov.
Article in English | MEDLINE | ID: mdl-28916543

ABSTRACT

OBJECTIVE: To evaluate the rate of somatic NLRP3 mosaicism in an Italian cohort of mutation-negative patients with cryopyrin-associated periodic syndrome (CAPS). METHODS: The study enrolled 14 patients with a clinical phenotype consistent with CAPS in whom Sanger sequencing of the NLRP3 gene yielded negative results. Patients' DNA were subjected to amplicon-based NLRP3 deep sequencing. RESULTS: Low-level somatic NLRP3 mosaicism has been detected in 4 patients, 3 affected with chronic infantile neurological cutaneous and articular syndrome and 1 with Muckle-Wells syndrome. Identified nucleotide substitutions encode for 4 different amino acid exchanges, with 2 of them being novel (p.Y563C and p.G564S). In vitro functional studies confirmed the deleterious behavior of the 4 somatic NLRP3 mutations. Among the different neurological manifestations detected, 1 patient displayed mild loss of white matter volume on brain magnetic resonance imaging. CONCLUSION: The allele frequency of somatic NLRP3 mutations occurs generally under 15%, considered the threshold of detectability using the Sanger method of DNA sequencing. Consequently, routine genetic diagnostic of CAPS should be currently performed by next-generation techniques ensuring high coverage to identify also low-level mosaicism, whose actual frequency is yet unknown and probably underestimated.


Subject(s)
Brain/diagnostic imaging , Cryopyrin-Associated Periodic Syndromes/genetics , Mosaicism , NLR Family, Pyrin Domain-Containing 3 Protein/genetics , Child , Child, Preschool , Cryopyrin-Associated Periodic Syndromes/diagnostic imaging , Female , High-Throughput Nucleotide Sequencing , Humans , Infant , Infant, Newborn , Italy , Magnetic Resonance Imaging , Male , White Matter/diagnostic imaging
4.
J Dtsch Dermatol Ges ; 14(10): 989-993, 2016 Oct.
Article in English | MEDLINE | ID: mdl-27767278

ABSTRACT

A rare eosinophilic dermatosis, Wells syndrome, also referred to as eosinophilic cellulitis, is characterized by great clinical variability. Typical findings include infiltrated erythematous plaques arising on the extremities. Lesions initially resemble erysipelas/cellulitis, however, they do not improve with antibiotic treatment. Eosinophilic cellulitis is a diagnosis of exclusion that may only be made over the course of the disease, taking into account clinical and characteristic histological findings (flame figures). Although multiple potential triggers have been proposed, the exact etiology remains unresolved. Involvement of abnormal Th2 cells, IL-5, and activated eosinophilic granulocytes suggest a nonspecific hypersensitivity response to exogenous or endogenous stimuli. Corticosteroids may have a beneficial effect on the chronic, recurrent course frequently observed. The disease is often self-limiting, healing without sequelae. Given that transitions to hematological and oncological disorders have been observed, patients should be closely followed up.


Subject(s)
Adrenal Cortex Hormones/therapeutic use , Cryopyrin-Associated Periodic Syndromes/diagnostic imaging , Cryopyrin-Associated Periodic Syndromes/drug therapy , Dermoscopy/methods , Eosinophilia/diagnosis , Eosinophilia/drug therapy , Cryopyrin-Associated Periodic Syndromes/pathology , Dermatologic Agents/therapeutic use , Diagnosis, Differential , Eosinophilia/pathology , Evidence-Based Medicine , Humans , Treatment Outcome
5.
Cephalalgia ; 36(14): 1392-1396, 2016 Dec.
Article in English | MEDLINE | ID: mdl-26848126

ABSTRACT

BACKGROUND: Tolosa-Hunt syndrome (THS) is characterized by unilateral orbital pain, ipsilateral oculomotor paresis and a prompt response to treatment with corticosteroids. Several reports have demonstrated that the clinical features of THS are not specific to one causal aetiology and can lead to misdiagnosis. CASE REPORT: We report the case of a patient diagnosed with THS after an episode of unilateral orbital pain and diplopia with demonstration of granulomatous inflammation of both cavernous sinus on cerebral magnetic resonance imaging and an immediate response to treatment with corticosteroids. Progression of the disease over the following years, accompanied by increasing signs of inflammation on cerebral magnetic resonance imaging and cerebrospinal fluid pleocytosis, led to further diagnostic tests. Genetic analyses revealed a heterozygote low-penetrance mutation (Q703K) of the cryopyrin/NLRP3 gene compatible with a cryopyrin-associated periodic fever syndrome. DISCUSSION: This case report demonstrates that THS can be a central nervous system manifestation of cryopyrin-associated periodic fever syndrome, which therefore represents a differential diagnosis of THS, even in elderly patients.


Subject(s)
Cryopyrin-Associated Periodic Syndromes/complications , Cryopyrin-Associated Periodic Syndromes/diagnostic imaging , Fever/complications , Fever/diagnostic imaging , Tolosa-Hunt Syndrome/complications , Tolosa-Hunt Syndrome/diagnostic imaging , Diagnosis, Differential , Humans , Male , Middle Aged , Ophthalmoplegia/complications , Ophthalmoplegia/diagnostic imaging
6.
Rheumatology (Oxford) ; 53(10): 1783-7, 2014 Oct.
Article in English | MEDLINE | ID: mdl-24821850

ABSTRACT

OBJECTIVE: Chronic inflammation plays a key role in the development of atherosclerosis. Early progression of atherosclerosis has been reported in patients with RA. Cryopyrin-associated periodic syndromes (CAPS) are autosomal dominant autoinflammatory disorders caused by heterozygous NLRP3 gene mutations. Chronic infantile neurological cutaneous and articular (CINCA) syndrome is the most severe form of CAPS and patients display early onset of rash, fever, uveitis and joint manifestations. However, there has been no previous report on atherosclerosis in patients with CAPS. The objective of this study is to assess the development of atherosclerosis in patients with CINCA syndrome. METHODS: Intima-media thickness (IMT) of the carotid arteries, stiffness parameter ß, ankle brachial index (ABI) and pressure wave velocity (PWV) were evaluated by ultrasonography in 3 patients with CINCA syndrome [mean age 9.0 years (S.D. 5.3)] and 19 age-matched healthy controls [9.3 years (S.D. 4.3)]. RESULTS: The levels of carotid IMT, stiffness parameter ß and PWV in CINCA syndrome patients were significantly higher than those in healthy controls [0.51 mm (S.D. 0.05) vs 0.44 (0.04), P = 0.0021; 6.1 (S.D. 1.7) vs 3.9 (1.0), P = 0.0018; 1203 cm/s (S.D. 328) vs 855 (114), P = 0.017, respectively]. CONCLUSION: Patients with CINCA syndrome showed signs of atherosclerosis from their early childhood. The results of this study emphasize the importance of chronic inflammation in the development of atherosclerosis. Further analysis on atherosclerosis in young patients with CINCA syndrome may provide more insights into the pathogenesis of cardiovascular disease.


Subject(s)
Atherosclerosis/diagnostic imaging , Cryopyrin-Associated Periodic Syndromes/diagnostic imaging , Adolescent , Atherosclerosis/complications , Carotid Intima-Media Thickness , Child , Child, Preschool , Cryopyrin-Associated Periodic Syndromes/complications , Disease Progression , Female , Humans , Male
7.
J Radiol Case Rep ; 6(3): 1-8, 2012 Mar.
Article in English | MEDLINE | ID: mdl-22690285

ABSTRACT

Neonatal onset multisystem inflammatory disease (NOMID) is a rare autoinflammatory disorder, which manifests early in infancy. We describe a case of a 10-year-old boy who has been unwell since infancy. He presented with urticarial rash, intermittent fever and hepatosplenomegaly followed by progressive arthropathy. His joint symptoms started at two years of age, which progressively involved multiple joints, resulting in bone and joint deformities. A series of joint radiographs demonstrated bizarre enlarging physeal mass with heterogenous calcification. Magnetic resonance imaging (MRI) of the involved right ankle and knee showed characteristic thickened and calcified physeal lesions, which enhanced post-gadolinium. This debilitating disease is also known to involve the central nervous system and eyes. This case report aims to highlight the conventional radiographic and magnetic resonance imaging (MRI) findings of this physeal abnormality in NOMID syndrome.


Subject(s)
Cryopyrin-Associated Periodic Syndromes/diagnostic imaging , Cryopyrin-Associated Periodic Syndromes/pathology , Ankle Joint/diagnostic imaging , Ankle Joint/pathology , Arthritis/etiology , Child , Exanthema/etiology , Humans , Knee Joint/diagnostic imaging , Knee Joint/pathology , Magnetic Resonance Imaging , Male , Radiography
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