1.
J Nat Prod
; 78(11): 2537-44, 2015 Nov 25.
Article
in English
| MEDLINE
| ID: mdl-26496427
ABSTRACT
A phytochemical study of dart and arrow poison from the Matis tribe led to the identification of D-(-)-quinic acid, L-malic acid, ethyldimethylamine, magnoflorine, and five new bisbenzyltetrahydroisoquinoline alkaloids (BBIQAs), 1-5. D-Tubocurarine could not be identified among these products. BBIQA (3) contains a unique linkage at C-8 and C-11'. All structures were characterized by a combination of NMR and HRESIMS data. The effects of Matis poison and individual BBIQAs (1-3) on rat muscle nAChR expressed in Xenopus oocytes have been investigated using the two-electrode voltage clamp technique.
Subject(s)
Alkaloids/isolation & purification , Curare/isolation & purification , Tubocurarine/isolation & purification , Alkaloids/pharmacology , Animals , Curare/chemistry , Molecular Structure , Oocytes/drug effects , Poisons/pharmacology , Rats , Tubocurarine/pharmacology
2.
Anesthesiology
; 57(6): 519-26, 1982 Dec.
Article
in English
| MEDLINE
| ID: mdl-6756214
3.
Ann Pharm Fr
; 29(5): 353-64, 1971.
Article
in French
| MEDLINE
| ID: mdl-5124766
Subject(s)
Curare/isolation & purification , Plants, Medicinal , Africa, Central , Animals , Anura , In Vitro Techniques , Rats
4.
Int Anesthesiol Clin
; 6(2): 518-30, 1968.
Article
in English
| MEDLINE
| ID: mdl-4895827
5.
Ann Ist Super Sanita
; 3(3): 378-85, 1967.
Article
in Italian
| MEDLINE
| ID: mdl-5618694
Subject(s)
Curare/isolation & purification , Animals , Brazil , Curare/analysis , Curare/toxicity , Methods , Mice , Technology, Pharmaceutical
6.
Carib Med J
; 12(3-4): 119, 1950.
Article
in English
| MedCarib
| ID: med-3871
