Oral Intake of Hydrangea serrata (Thunb.) Ser. Leaves Extract Improves Wrinkles, Hydration, Elasticity, Texture, and Roughness in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study.

Previously, we reported that the hot water extract of Hydrangea serrata leaves (WHS) and its active component, hydrangenol, possess in vitro and in vivo effects on skin wrinkles and moisturization. We conducted a randomized, double-blind, placebo-controlled trial to clinically evaluate the effect of WHS on human skin. Participants (n = 151) were randomly assigned to receive either WHS 300 mg, WHS 600 mg, or placebo, once daily for 12 weeks. Skin wrinkle, hydration, elasticity, texture, and roughness parameters were assessed at baseline and after 4, 8, and 12 weeks. Compared to the placebo, skin wrinkles were significantly reduced in both WHS groups after 8 and 12 weeks. In both WHS groups, five parameters (R1-R5) of skin wrinkles significantly improved and skin hydration was significantly enhanced when compared to the placebo group after 12 weeks. Compared with the placebo, three parameters of skin elasticity, including overall elasticity (R2), net elasticity (R5), and ratio of elastic recovery to total deformation (R7), improved after 12 weeks of oral WHS (600 mg) administration. Changes in skin texture and roughness were significantly reduced in both WHS groups. No WHS-related adverse reactions were reported. Hence, WHS could be used as a health supplement for skin anti-aging.

[Syndrome of excessive growth of the cutaneous integument in spinal cord hernias]. / Sindrom izbytochnogo razvitiia kozhnykh pokrovov pri spinnomozgovykh gryzhakh.

Combination of clinical manifestations of skin hyperplasia in spinal hernias with signs of connective tissue lesion (articular hypermobility, skin hyperelasticity, trophic disorders) indicates involvement of the spinal cord and its radicles which is confirmed by electromyographic findings. Early surgical treatment of spinal hernias prevents the development of irreversible changes in the nervous system and progression of neurological manifestations. It is also important that such patients find occupation which would not be associated with excessive strain on the vertebral column and overextension of the limb ligaments.