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[Determination of the inhibitors of the oil-soluble salt of dicyclohexylamine and of dicyclohexylamine nitrite in air by a thin-layer chromatographic method]. / Opredelenie ingibitorov maslorastvorimoi soli ditsiklogeksilamina i nitrita ditsiklogeksilamina v vozdukhe metodom khromatografii v tonkom sloe

Voloshina, E I.

Gig Tr Prof Zabol ; (3): 59-60, 1975 Mar.

Article in Russian | MEDLINE | ID: mdl-1126657

Subject(s)

Air/analysis , Chromatography, Thin Layer/methods , Cyclohexylamines/antagonists & inhibitors , Cyclohexylamines/analogs & derivatives , Cyclohexylamines/analysis

[Activity and properties of RNA-dependent RNA polymerase induced in cell cultures infected with Venezuelan equine encephalomyelitis virus]. / Izuchenie aktivnosti i nekotorykh svoistv RNK-zavisimoi RNK-polimerazy, indutirovannoi v kul'ture kletok, zarazhennykh virusom venesuél'skogo éntsefalomielita loshadei

Pravdina, N F; Nikishina, V I; Dikii, V V; Zhdanov, V M.

Vopr Virusol ; (1): 74-8, 1975.

Article in Russian | MEDLINE | ID: mdl-1168389

ABSTRACT

The activity and properties of RNA-dependent RNA-polymerase in cells infected with Venezuelan equine encephalomyelitis virus were studied. The maximum activity of the enzyme was found 4-5 hours after infection. The effect of two synthetic drugs (rimantadine and diacetylaminocyclohexenon) with antiviral activity against some viruses on RNA-polymerase was studied. Rimantadine was shown to have no effect on the synthesis and activity of the enzyme. Diacetylaminocyclohexenon added into the growth medium was found to inhibit production of RNA-polymerase by 35-40% without reducing the activity of the enzyme in vitro.

Subject(s)

DNA-Directed RNA Polymerases/metabolism , Encephalitis Virus, Venezuelan Equine/growth & development , Virus Replication , Acetates/pharmacology , Adenosine Triphosphate , Animals , Antiviral Agents/pharmacology , Bridged-Ring Compounds/pharmacology , Chick Embryo , Cyclohexylamines/analogs & derivatives , Cyclohexylamines/pharmacology , Cycloparaffins/pharmacology , Cytosine Nucleotides , DNA-Directed RNA Polymerases/biosynthesis , Dactinomycin , Encephalitis Virus, Venezuelan Equine/drug effects , Ethylamines/pharmacology , Fibroblasts/enzymology , Guanine Nucleotides , Magnesium , RNA, Viral/biosynthesis , Tritium , Uracil Nucleotides , Uridine , Virus Replication/drug effects

[Antagonism of dextran sulphate and desoxystreptamine antibiotics (author's transl)]. / Antagonismus dextran sulfátu a deoxystreptaminových antibiotik

Potuzník, V.

Cesk Epidemiol Mikrobiol Imunol ; 23(6): 348-51, 1974 Dec.

Article in Czech | MEDLINE | ID: mdl-4281356

Subject(s)

Anti-Bacterial Agents/antagonists & inhibitors , Bacteria/drug effects , Cyclohexanols/analogs & derivatives , Dextrans/pharmacology , Cyclohexanols/pharmacology , Cyclohexylamines/analogs & derivatives , Cyclohexylamines/pharmacology , Deoxy Sugars/pharmacology , Microbial Sensitivity Tests , Sulfates/pharmacology

1-(3,4-Dichlorobenzamidomethyl)cyclohexyldimethylamine and related compounds as potential analgesics.

Harper, N J; Veitch, G B; Wibberley, D G.

J Med Chem ; 17(11): 1188-93, 1974 Nov.

Article in English | MEDLINE | ID: mdl-4416926

Subject(s)

Analgesics/chemical synthesis , Cyclohexylamines/analogs & derivatives , Administration, Oral , Analgesics/administration & dosage , Analgesics/pharmacology , Animals , Behavior, Animal/drug effects , Benzamides/administration & dosage , Benzamides/chemical synthesis , Benzamides/pharmacology , Body Temperature/drug effects , Central Nervous System/drug effects , Cyclohexylamines/administration & dosage , Cyclohexylamines/chemical synthesis , Cyclohexylamines/pharmacology , Depression, Chemical , Electroshock , Injections, Subcutaneous , Mice , Pentylenetetrazole/antagonists & inhibitors , Quinones/antagonists & inhibitors , Reaction Time , Seizures/prevention & control , Structure-Activity Relationship

[Controlled trial of drugs with antispastic and antispastic-analgesic action]. / Sperimentazione controllata di farmaci ad azione antispastica ed antispastica-analgesica

Di Carlo, V.

Clin Ter ; 70(5): 451-63, 1974 Sep 15.

Article in Italian | MEDLINE | ID: mdl-4424925

Subject(s)

Analgesics/therapeutic use , Biliary Tract Diseases/drug therapy , Cyclohexylamines/analogs & derivatives , Methylamines/therapeutic use , Parasympatholytics/therapeutic use , Pyrazoles/therapeutic use , Urologic Diseases/drug therapy , Adolescent , Adult , Aged , Analgesics/adverse effects , Appendicitis/complications , Cholecystitis/complications , Cholelithiasis/complications , Female , Humans , Intestinal Obstruction/complications , Male , Middle Aged , Pancreatitis/complications , Parasympatholytics/adverse effects , Urinary Calculi/complications , Urinary Tract Infections/complications

Malonyl and succinyl dicyclohexylamides and allied compounds as potential antiinflammatory agents.

Gieldanowski, J; Bobranski, B; Deckert, J; Szaga, B.

Farmaco Sci ; 29(2): 91-4, 1974 Feb.

Article in English | MEDLINE | ID: mdl-4609790

Subject(s)

Anti-Inflammatory Agents/chemical synthesis , Cyclohexylamines/analogs & derivatives , Allyl Compounds/chemical synthesis , Amides/chemical synthesis , Animals , Anti-Inflammatory Agents/administration & dosage , Anti-Inflammatory Agents/pharmacology , Anti-Inflammatory Agents/therapeutic use , Anti-Inflammatory Agents/toxicity , Arthritis/drug therapy , Cell Survival/drug effects , Cyclohexylamines/chemical synthesis , Freund's Adjuvant , Guinea Pigs , Injections, Intraperitoneal , Lethal Dose 50 , Malonates/chemical synthesis , Mice , Rats , Skin Transplantation , Succinates/chemical synthesis , Transplantation, Homologous

[Use of the anticholinergic and antispasmodic agent pramiverin (HSp 2986, E. Merck) to obtain medical vagotomy]. / Empleo del anticolinérgico y antiespasmódico pramiverin (HSp 2986, E. Merck) para obtener vagotomía médica

Morel, C J.

Rev Esp Enferm Apar Dig ; 42(1): 73-80, 1974 Jan 01.

Article in Spanish | MEDLINE | ID: mdl-4460118

Subject(s)

Cyclohexylamines/analogs & derivatives , Duodenal Ulcer/drug therapy , Parasympatholytics/therapeutic use , Vagotomy/methods , Vagus Nerve/drug effects , Adult , Aged , Benzene Derivatives/therapeutic use , Cyclohexylamines/therapeutic use , Drug Evaluation , Gastric Acidity Determination , Gastric Mucosa/physiology , Humans , Middle Aged , Parasympatholytics/pharmacology , Stimulation, Chemical

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